Recent advances in the understanding of brown spider venoms: From the biology of spiders to the molecular mechanisms of toxins

dc.contributorUniversidade Federal do Paraná (UFPR)
dc.contributorUniv Estadual Ponta Grossa
dc.contributorUniversidade Federal de Minas Gerais (UFMG)
dc.contributorUniversidade Estadual Paulista (Unesp)
dc.contributorInstituto Butantan
dc.contributorCtr Nacl Pesquisa Energia & Mat
dc.creatorGremski, Luiza Helena
dc.creatorTrevisan-Silva, Dilza
dc.creatorFerrer, Valeria Pereira
dc.creatorMatsubara, Fernando Hitomi
dc.creatorMeissner, Gabriel Otto
dc.creatorMartins Wille, Ana Carolina
dc.creatorVuitika, Larissa
dc.creatorDias-Lopes, Camila
dc.creatorUllah, Anwar [UNESP]
dc.creatorMoraes, Fabio Rogerio de [UNESP]
dc.creatorChavez-Olortegui, Carlos
dc.creatorBarbaro, Katia Cristina
dc.creatorMurakami, Mario Tyago
dc.creatorArni, Raghuvir Krishnaswamy [UNESP]
dc.creatorSenff-Ribeiro, Andrea
dc.creatorChaim, Olga Meiri
dc.creatorVeiga, Silvio Sanches
dc.date2014-12-03T13:11:09Z
dc.date2014-12-03T13:11:09Z
dc.date2014-06-01
dc.date.accessioned2023-09-09T10:06:39Z
dc.date.available2023-09-09T10:06:39Z
dc.identifierhttp://dx.doi.org/10.1016/j.toxicon.2014.02.023
dc.identifierToxicon. Oxford: Pergamon-elsevier Science Ltd, v. 83, p. 91-120, 2014.
dc.identifier0041-0101
dc.identifierhttp://hdl.handle.net/11449/112906
dc.identifier10.1016/j.toxicon.2014.02.023
dc.identifierWOS:000335876300011
dc.identifier9162508978945887
dc.identifier0000-0003-2460-1145
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/8762524
dc.descriptionThe Loxosceles genus spiders (the brown spiders) are encountered in all the continents, and the clinical manifestations following spider bites include skin necrosis with gravitational lesion spreading and occasional systemic manifestations, such as intravascular hemolysis, thrombocytopenia and acute renal failure. Brown spider venoms are complex mixtures of toxins especially enriched in three molecular families: the phospholipases D, astacin-like metalloproteases and Inhibitor Cystine Knot (ICK) peptides. Other toxins with low level of expression also present in the venom include the serine proteases, serine protease inhibitors, hyaluronidases, allergen factors and translationally controlled tumor protein (TCTP). The mechanisms by which the Loxosceles venoms act and exert their noxious effects are not fully understood. Except for the brown spider venom phospholipase D, which causes dermonecrosis, hemolysis, thrombocytopenia and renal failure, the pathological activities of the other venom toxins remain unclear. The objective of the present review is to provide insights into the brown spider venoms and loxoscelism based on recent results. These insights include the biology of brown spiders, the clinical features of loxoscelism and the diagnosis and therapy of brown spider bites. Regarding the brown spider venom, this review includes a description of the novel toxins revealed by molecular biology and proteomics techniques, the data regarding three-dimensional toxin structures, and the mechanism of action of these molecules. Finally, the biotechnological applications of the venom components, especially for those toxins reported as recombinant molecules, and the challenges for future study are discussed. (C) 2014 Elsevier Ltd. All rights reserved.
dc.descriptionCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.descriptionConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.descriptionFundação de Amparo à Pesquisa do Estado de Minas Gerais (FAPEMIG)
dc.descriptionINCTTOX
dc.descriptionFundacao Araucaria-Parana
dc.descriptionSecretaria de Tecnologia e Ensino Superior do Parana, SETI-PR, Brasil
dc.descriptionUniv Fed Parana, Dept Biol Celular, BR-81531990 Curitiba, Parana, Brazil
dc.descriptionUniv Fed Parana, Hosp Clin, Dept Patol Clin, BR-81531990 Curitiba, Parana, Brazil
dc.descriptionUniv Estadual Ponta Grossa, Dept Biol Estrutural Mol & Genet, Ponta Grossa, Parana, Brazil
dc.descriptionUniv Fed Minas Gerais, ICB, Dept Bioquim & Imunol, Belo Horizonte, MG, Brazil
dc.descriptionUniv Estadual Paulista UNESP, Dept Fis, Ctr Multiusutirio Inovacao Biomol, Sao Jose Do Rio Preto, SP, Brazil
dc.descriptionInst Butantan, Lab Imunopatol, Sao Paulo, Brazil
dc.descriptionCtr Nacl Pesquisa Energia & Mat, Lab Nacl Biociencias LNBio, Campinas, SP, Brazil
dc.descriptionUniv Estadual Paulista UNESP, Dept Fis, Ctr Multiusutirio Inovacao Biomol, Sao Jose Do Rio Preto, SP, Brazil
dc.format91-120
dc.languageeng
dc.publisherElsevier B.V.
dc.relationToxicon
dc.relation2.352
dc.relation0,692
dc.rightsAcesso restrito
dc.sourceWeb of Science
dc.subjectBrown spider
dc.subjectLoxosceles
dc.subjectVenom
dc.subjectToxins
dc.subjectLoxoscelism
dc.subjectDermonecrosis
dc.titleRecent advances in the understanding of brown spider venoms: From the biology of spiders to the molecular mechanisms of toxins
dc.typeArtigo


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