Association among XRCC1, XRCC3, and BLHX gene polymorphisms and chromosome instability in lymphocytes from patients with endometriosis and ovarian cancer

dc.contributorUniversidade Estadual Paulista (Unesp)
dc.contributorUniversidade de São Paulo (USP)
dc.creatorMonteiro, M. S. [UNESP]
dc.creatorBoas, D. B. Vilas
dc.creatorGigliotti, C. B.
dc.creatorSalvadori, Daisy Maria Favero [UNESP]
dc.date2014-12-03T13:10:35Z
dc.date2014-12-03T13:10:35Z
dc.date2014-01-01
dc.date.accessioned2023-09-09T09:56:55Z
dc.date.available2023-09-09T09:56:55Z
dc.identifierhttp://dx.doi.org/10.4238/2014.January.28.9
dc.identifierGenetics And Molecular Research. Ribeirao Preto: Funpec-editora, v. 13, n. 1, p. 636-648, 2014.
dc.identifier1676-5680
dc.identifierhttp://hdl.handle.net/11449/112290
dc.identifier10.4238/2014.January.28.9
dc.identifierWOS:000331846400067
dc.identifierWOS000331846400067.pdf
dc.identifier5051118752980903
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/8761921
dc.descriptionEndometriosis is a complex disease that has both benign and malignant characteristics. It affects 5-10% of women of reproductive age. Studies have demonstrated the existence of common genetic changes in endometriosis and ovarian cancer, suggesting a possible association between these 2 diseases. However, the mechanisms that lead to the development of cancer from endometriosis remain unknown. In this study, we evaluated 3 groups of women: 72 patients with endometriosis, 70 with ovarian cancer, and 70 healthy individuals (controls). Repair (XRCC1 codons 194 and 399, XPD codons 312 and 751, and XRCC3 codon 241)- and metabolism (BLHX codon 443)-related gene polymorphisms were analyzed using the polymerase chain reaction-restriction fragment length polymorphism technique; the efficiency of DNA damage repair was analyzed in vitro in lymphocytes exposed to bleomycin. The logistic regression model was used to evaluate key associations. The results showed an increased average of chromosome breakage in bleomycin-treated lymphocytes from patients with endometriosis and ovarian cancer compared with healthy women. We also detected significant association between XRCC1, XRCC3, and BLHX polymorphisms and a high frequency of chromosomal damage. Women with endometriosis or ovarian cancer may have an altered mechanism of DNA repair, and these defects may be related to a higher incidence of ovarian cancer.
dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.descriptionUniv Estadual Paulista, Fac Med Botucatu, Dept Patol, Lab Toxicogenom & Nutrigenom, Botucatu, SP, Brazil
dc.descriptionUniv Sagrado Coracao, Ctr Ciencias Saude, Bauru, SP, Brazil
dc.descriptionUniv Estadual Paulista, Fac Med Botucatu, Dept Patol, Lab Toxicogenom & Nutrigenom, Botucatu, SP, Brazil
dc.descriptionFAPESP: 06/60417-9
dc.format636-648
dc.languageeng
dc.publisherFunpec-editora
dc.relationGenetics and Molecular Research
dc.relation0,439
dc.rightsAcesso aberto
dc.sourceWeb of Science
dc.subjectCancer
dc.subjectChromosome aberration
dc.subjectDNA repair genes
dc.subjectMolecular epidemiology
dc.titleAssociation among XRCC1, XRCC3, and BLHX gene polymorphisms and chromosome instability in lymphocytes from patients with endometriosis and ovarian cancer
dc.typeArtigo


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