Indoleamine 2,3-dioxygenase (IDO) Activity in Placental Compartments of Renal-Transplanted Pregnant Women

dc.contributorUniversidade de São Paulo (USP)
dc.contributorUniversidade Estadual Paulista (Unesp)
dc.contributorUniversidade Federal de São Paulo (UNIFESP)
dc.creatorPrado, Karen Matias do
dc.creatorCorrea-Silva, Simone [UNESP]
dc.creatorOliveira, Leandro Gustavo de [UNESP]
dc.creatorSaraiva Camara, Niels Olsen
dc.creatorOno, Erica
dc.creatorSandri, Silvana
dc.creatorTourino, Melissa Cavalheiro
dc.creatorCampa, Ana
dc.creatorLima, Larissa de Sa
dc.creatorScavone, Cristoforo
dc.creatorBevilacqua, Estela
dc.date2014-12-03T13:10:33Z
dc.date2014-12-03T13:10:33Z
dc.date2014-07-01
dc.date.accessioned2023-09-09T09:56:11Z
dc.date.available2023-09-09T09:56:11Z
dc.identifierhttp://dx.doi.org/10.1111/aji.12233
dc.identifierAmerican Journal Of Reproductive Immunology. Hoboken: Wiley-blackwell, v. 72, n. 1, p. 45-56, 2014.
dc.identifier1046-7408
dc.identifierhttp://hdl.handle.net/11449/112242
dc.identifier10.1111/aji.12233
dc.identifierWOS:000337752700006
dc.identifier0720794820325913
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/8761874
dc.descriptionProblem Immunosuppressive drugs change gestational IDO activity at the maternal-fetal interface. Method of Study Analysis of placental IDO expression and activity, interferon gamma (IFN-), and IL-10 expression and NFkB activity in renal transplant recipient women under immunosuppressive treatment. Results We demonstrated a significant reduction in IDO activity (P=0.0275) and expression (P=0.026) and in NFkB activity (P=0.0176) in the villous region of renal transplanted mother. These findings did not correlate with the higher serum levels of kynurenine (P=0.002). In the decidual compartment, IDO was immunolocalized mainly on the extravillous cytotrophoblast but did not show significant differences among the experimental groups; kynurenine was significantly higher (P=0.036) and was inversely proportional to the decidual IFN- profile (P=0.0433). No change was seen in IL-10 levels. NFkB activity was significantly higher in decidual compartment correlating with the higher IDO activity and suggesting that in immunosuppressant pregnancy, IDO activity and expression remain regulated by NFkB. Conclusion The increased IDO activity in decidua may indicate an attempt to offset the low expression. These findings call attention to the relevance of IDO activity at the maternal interface in pregnant transplant recipients, likely modulated by immunosuppressive agents and associated with a high risk of associated gestational disorders.
dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.descriptionCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.descriptionConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.descriptionUniv Sao Paulo, Inst Biomed Sci, Dept Cell & Dev Biol, Sao Paulo, Brazil
dc.descriptionUNESP Sao Paulo State Univ, Botucatu Med Sch, Postgrad Program Gynecol Obstet & Mastol, Botucatu, SP, Brazil
dc.descriptionUniv Sao Paulo, Inst Biomed Sci, Dept Immunol, Sao Paulo, Brazil
dc.descriptionUniv Fed Sao Paulo, Sch Med, Dept Pediat, Sao Paulo, Brazil
dc.descriptionUniv Sao Paulo, Fac Pharmaceut Sci, Dept Clin & Toxicol Anal, Sao Paulo, Brazil
dc.descriptionUniv Sao Paulo, Inst Biomed Sci, Dept Pharmacol, Sao Paulo, Brazil
dc.descriptionUNESP Sao Paulo State Univ, Botucatu Med Sch, Postgrad Program Gynecol Obstet & Mastol, Botucatu, SP, Brazil
dc.format45-56
dc.languageeng
dc.publisherWiley-Blackwell
dc.relationAmerican Journal of Reproductive Immunology
dc.relation2.745
dc.relation1,210
dc.rightsAcesso restrito
dc.sourceWeb of Science
dc.subjectIDO
dc.subjectIFN-
dc.subjectImmunosuppressive drugs
dc.subjectKynurenine
dc.subjectNF-B
dc.subjectPlacenta
dc.titleIndoleamine 2,3-dioxygenase (IDO) Activity in Placental Compartments of Renal-Transplanted Pregnant Women
dc.typeArtigo


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