Aldosterone Blockade Reduces Mortality without Changing Cardiac Remodeling in Spontaneously Hypertensive Rats

dc.contributorUniversidade Estadual Paulista (Unesp)
dc.contributorUniversidade Federal de Mato Grosso do Sul (UFMS)
dc.creatorCezar, Marcelo D. M. [UNESP]
dc.creatorDamatto, Ricardo L. [UNESP]
dc.creatorMartinez, Paula F.
dc.creatorLima, Aline R. R. [UNESP]
dc.creatorCampos, Dijon H. S. [UNESP]
dc.creatorRosa, Camila M. [UNESP]
dc.creatorGuizoni, Daniele M. [UNESP]
dc.creatorBonomo, Camila [UNESP]
dc.creatorCicogna, Antonio Carlos [UNESP]
dc.creatorGimenes, Rodrigo [UNESP]
dc.creatorPagan, Luana U. [UNESP]
dc.creatorOkoshi, Marina Politi [UNESP]
dc.creatorOkoshi, Katashi [UNESP]
dc.date2014-12-03T13:10:29Z
dc.date2014-12-03T13:10:29Z
dc.date2013-01-01
dc.date.accessioned2023-09-09T09:55:16Z
dc.date.available2023-09-09T09:55:16Z
dc.identifierhttp://dx.doi.org/10.1159/000354526
dc.identifierCellular Physiology And Biochemistry. Basel: Karger, v. 32, n. 5, p. 1275-1287, 2013.
dc.identifier1015-8987
dc.identifierhttp://hdl.handle.net/11449/112184
dc.identifier10.1159/000354526
dc.identifierWOS:000328699600014
dc.identifierWOS000328699600014.pdf
dc.identifier9418970103564137
dc.identifier4463138671998432
dc.identifier1590971576309420
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/8761816
dc.descriptionBackground: The role of aldosterone blockers during transition from long-term compensated hypertrophy to dilated failure is not completely understood. In this study we evaluated the effects of early administration of spironolactone on cardiac remodeling, myocardial function, and mortality in spontaneously hypertensive rats (SHR). Methods: Sixteen-month-old SHR received no treatment (SHR-C, n=72) or spironolactone (SHR-SPR, 20 mg/kg/day, n=34) for six months. Echocardiogram was performed before and after treatment. Myocardial function was analyzed in left ventricular (LV) papillary muscle preparations. Myocardial collagen aund hydroxyproline concentration were evaluated by morphometry and spectrophotometry, respectively. LV gene expression was assessed by real time RT-PCR. Statistics: Student's t test; Log rank test (Kaplan Meyer). Results: SHR-C and SHR-SPR presented mortality rates of 71 and 38%, respectively (p=0.004). Systolic arterial pressure did not differ between groups (SHR-C 199 +/- 43; SHR-SPR 200 +/- 35 mmHg). Initial and final echocardiograms did not show significant differences in cardiac structures or LV function between groups. Myocardial function was similar between groups at basal and after inotropic stimulation. Collagen fractional area, hydroxyproline concentration, gene expression for alpha- and beta-myosin heavy chain, atrial natriuretic peptide, and Serca2a were not different between groups. Conclusion: Early spironolactone administration reduces mortality without changing cardiac remodeling in spontaneous hypertensive rats. Copyright (C) 2013 S. Karger AG, Basel
dc.descriptionConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.descriptionSao Paulo State Univ, Botucatu Med Sch, Dept Internal Med, Botucatu, SP, Brazil
dc.descriptionUNESP, Botucatu Med Sch, BR-18618970 Botucatu, SP, Brazil
dc.descriptionUniv Fed Mato Grosso do Sul, Campo Grande, Brazil
dc.descriptionSao Paulo State Univ, Botucatu Med Sch, Dept Internal Med, Botucatu, SP, Brazil
dc.descriptionUNESP, Botucatu Med Sch, BR-18618970 Botucatu, SP, Brazil
dc.descriptionCNPq: 305013/2009-0
dc.descriptionCNPq: 304998/2009-5
dc.descriptionFAPESP: 07/57497-3
dc.descriptionFAPESP: 09/54407-9
dc.descriptionFAPESP: 09/54506-7
dc.format1275-1287
dc.languageeng
dc.publisherKarger
dc.relationCellular Physiology and Biochemistry
dc.relation5.500
dc.relation1,561
dc.rightsAcesso aberto
dc.sourceWeb of Science
dc.subjectHeart failure
dc.subjectMyocardial function
dc.subjectEchocardiogram
dc.subjectSpironolactone
dc.subjectVentricular function
dc.subjectPapillary muscle
dc.titleAldosterone Blockade Reduces Mortality without Changing Cardiac Remodeling in Spontaneously Hypertensive Rats
dc.typeArtigo


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