Systemic immunotoxicity reactions induced by adjuvanted vaccines

dc.contributorMed Sci Univ
dc.contributorUniversidade Estadual Paulista (Unesp)
dc.contributorCAPES PVE Brasil Grant
dc.contributorUniv Med Sci Havana
dc.creatorBatista-Duharte, Alexander [UNESP]
dc.creatorPortuondo, Deivys [UNESP]
dc.creatorPerez, O.
dc.creatorCarlos, Iracilda Zeppone [UNESP]
dc.date2014-12-03T13:09:12Z
dc.date2014-12-03T13:09:12Z
dc.date2014-05-01
dc.date.accessioned2023-09-09T09:53:23Z
dc.date.available2023-09-09T09:53:23Z
dc.identifierhttp://dx.doi.org/10.1016/j.intimp.2014.02.033
dc.identifierInternational Immunopharmacology. Amsterdam: Elsevier Science Bv, v. 20, n. 1, p. 170-180, 2014.
dc.identifier1567-5769
dc.identifierhttp://hdl.handle.net/11449/112063
dc.identifier10.1016/j.intimp.2014.02.033
dc.identifierWOS:000336337900023
dc.identifier1730146818754269
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/8761700
dc.descriptionVaccine safety is a topic of concern for the treated individual, the family, the health care personnel, and the others involved in vaccination programs as recipients or providers. Adjuvants are necessary components to warrant the efficacy of vaccines, however the overstimulation of the immune system is also associated with adverse effects. Local reactions are the most frequent manifestation of toxicity induced by adjuvanted vaccines and, with the exception of the acute phase response (APR), much less is known about the systemic reactions that follow vaccination. Their low frequency or subclinical expression meant that this matter has been neglected. In this review, various systemic reactions associated with immune stimulation will be addressed, including: APR, hypersensitivity, induction or worsening of autoimmune diseases, modification of hepatic metabolism and vascular leak syndrome (VLS), with an emphasis on the mechanism involved. Finally, the authors analyze the current focus of discussion about vaccine safety and opportunities to improve the design of new adjuvanted vaccines in the future. (C) 2014 Elsevier B.V. All rights reserved.
dc.descriptionUNESP
dc.descriptionCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.descriptionMed Sci Univ, Toxicol & Biomed Ctr TOXIMED, Immunotoxicol Lab, Santiago De Cuba 90400, Cuba
dc.descriptionUniv Estadual Paulista, UNESP, Fac Pharmaceut Sci, BR-14801902 Araraquara, SP, Brazil
dc.descriptionCAPES PVE Brasil Grant, Foreigner Visiting Prof Program, Araraquara, Brazil
dc.descriptionUniv Med Sci Havana, Inst Preclin & Basic Sci ICBP Victoria de Giron, Dept Immunol, Havana, Cuba
dc.descriptionUniv Estadual Paulista, UNESP, Fac Pharmaceut Sci, BR-14801902 Araraquara, SP, Brazil
dc.format170-180
dc.languageeng
dc.publisherElsevier B.V.
dc.relationInternational Immunopharmacology
dc.relation3.118
dc.relation1,051
dc.rightsAcesso restrito
dc.sourceWeb of Science
dc.subjectSystemic reactions
dc.subjectAdjuvant
dc.subjectVaccine
dc.subjectImmunotoxicity
dc.subjectAction mechanisms
dc.titleSystemic immunotoxicity reactions induced by adjuvanted vaccines
dc.typeArtigo


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