Surfactant-cosurfactant interactions and process parameters involved in the formulation of stable and small droplet-sized benznidazole-loaded soybean O/W emulsions

dc.contributorUniversidade Federal do Rio Grande do Norte (UFRN)
dc.contributorUniversidade Estadual Paulista (Unesp)
dc.creatorStreck, Leticia
dc.creatorAraujo, Margarete M. de
dc.creatorSouza, Izadora de
dc.creatorFernandes-Pedrosa, Matheus F.
dc.creatorEgito, Eryvaldo Socrates T. do
dc.creatorOliveira, Anselmo Gomes de [UNESP]
dc.creatorSilva-Junior, Arnobio A. da
dc.date2014-12-03T13:09:01Z
dc.date2014-12-03T13:09:01Z
dc.date2014-08-01
dc.date.accessioned2023-09-09T09:49:43Z
dc.date.available2023-09-09T09:49:43Z
dc.identifierhttp://dx.doi.org/10.1016/j.molliq.2014.03.033
dc.identifierJournal Of Molecular Liquids. Amsterdam: Elsevier Science Bv, v. 196, p. 178-186, 2014.
dc.identifier0167-7322
dc.identifierhttp://hdl.handle.net/11449/111828
dc.identifier10.1016/j.molliq.2014.03.033
dc.identifierWOS:000337857700024
dc.identifier9114495952533044
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/8761487
dc.descriptionThe ability of different surfactant mixtures (SM) (polysorbate 80/sorbitan monooleate, 5 to 10% w/w) with cosurfactants (CO) (benzyl alcohol, ethanol, and 2-methylpyrrolidone) to produce stable benznidazole (BNZ) loaded soybean oil (SO, 10 to 30% w/w) in water (O/tW) emulsions was well assessed. Statistical tests were performed to select the best procedure parameters (temperature, shake conditions, and order inversion phases), using a phase inversion technique (PIT). Phase behavior was assessed by the pseudo-ternary phase diagram at the best HLB (9.0). Physicochemical stability was assessed at different storage conditions (4 degrees C, 25 degrees C, and 45 degrees C, with thermal stress of 24 h at each temperature, 30 days). Rheological measurements demonstrated that all SO emulsions exhibited pseudoplastic flow-type (n-0.5) liquid-like behavior (k-0.19) with the absence of storage modulus (G') and a predominance of loss modulus (G '') even for the most concentrated emulsion (30% w/w SO), and confirmed stability regarding flocculation. The droplet size remained between 42 and 61 nm (PDI inferior to 03). However, benzyl alcohol contributed to an increase in droplet size, while 2-methylpyrrolidone led to the smallest droplet size. BNZ showed a weak interaction with the oil phase, but stable SO in water emulsions was produced with small and uniform droplet size containing a soluble drug fraction about four times greater than its aqueous solubility. (C) 2014 Elsevier B.V. All rights reserved.
dc.descriptionConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.descriptionCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.descriptionFederal University of Rio Grande do Norte
dc.descriptionUniv Fed Rio Grande do Norte, UFRN, Dept Pharm, Grad Program Pharmaceut Sci, BR-59072570 Natal, RN, Brazil
dc.descriptionState Univ Sao Paulo, UNESP, Sch Pharmaceut Sci, Dept Drug & Med, BR-14801902 Araraquara, SP, Brazil
dc.descriptionState Univ Sao Paulo, UNESP, Sch Pharmaceut Sci, Dept Drug & Med, BR-14801902 Araraquara, SP, Brazil
dc.descriptionCNPq: 483073/2010-5
dc.format178-186
dc.languageeng
dc.publisherElsevier B.V.
dc.relationJournal of Molecular Liquids
dc.relation4.513
dc.relation0,849
dc.rightsAcesso restrito
dc.sourceWeb of Science
dc.subjectEmulsion
dc.subjectSoybean oil
dc.subjectBenznidazole
dc.subjectPhysical stability
dc.subjectRheology
dc.subjectColloidal drug delivery systems
dc.titleSurfactant-cosurfactant interactions and process parameters involved in the formulation of stable and small droplet-sized benznidazole-loaded soybean O/W emulsions
dc.typeArtigo


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