Oncological Safety of Autologous Fat Grafting after Breast Conservative Treatment: A Prospective Evaluation

dc.contributorUniversidade Estadual de Campinas (UNICAMP)
dc.contributorSao Jose Hosp
dc.contributorEuropean Inst Oncol
dc.contributorUniversidade Estadual Paulista (Unesp)
dc.creatorBrenelli, Fabricio
dc.creatorRietjens, Mario
dc.creatorDe Lorenzi, Francesca
dc.creatorPinto-Neto, Aarao
dc.creatorRossetto, Fabio
dc.creatorMartella, Stefano
dc.creatorRodrigues, Jose R. P. [UNESP]
dc.creatorBarbalho, Daniel
dc.date2014-12-03T13:08:58Z
dc.date2014-12-03T13:08:58Z
dc.date2014-03-01
dc.date.accessioned2023-09-09T09:48:54Z
dc.date.available2023-09-09T09:48:54Z
dc.identifierhttp://dx.doi.org/10.1111/tbj.12225
dc.identifierBreast Journal. Hoboken: Wiley-blackwell, v. 20, n. 2, p. 159-165, 2014.
dc.identifier1075-122X
dc.identifierhttp://hdl.handle.net/11449/111775
dc.identifier10.1111/tbj.12225
dc.identifierWOS:000332600200007
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/8761434
dc.descriptionAutologous fat graft to the breast is a useful tool to correct defects after breast conservative treatment (BCT). Although this procedure gains popularity, little is known about the interaction between the fat graft and the prior oncological environment. Evidences of safety of this procedure in healthy breast and after post-mastectomy reconstruction exist. However, there is paucity of data among patients who underwent BCT which are hypothetically under a higher risk of local recurrence (LR). Fifty-nine patients, with prior BCT, underwent 75 autologous fat graft procedures using the Coleman's technique, between October 2005 and July 2008. Follow-up was made by clinical and radiologic examination at least once, after 6 months of the procedure. Mean age was 50 +/- 8.5 years, and mean follow-up was 34.4 +/- 15.3months. Mean time from oncological surgery to the first fat grafting procedure was 76.6 +/- 30.9months. Most of patients were at initial stage 0 (11.8%), I (33.8%), or IIA (23.7%). Immediate complication was observed in three cases (4%). Only three cases of true LR (4%) associated with the procedure were observed during the follow-up. Abnormal breast images were present in 20% of the postoperative mammograms, and in 8% of the cases, biopsy was warranted. Autologous fat graft is a safe procedure to correct breast defects after BCT, with low postoperative complications. Although it was not associated with increased risk of LR in the group of patients studied, prospective trials are needed to certify that it does not interfere in patient's oncological prognosis.
dc.descriptionState Univ Campinas Unicamp, Dept Gyanecol & Obstet, Breast Oncol Div, BR-13092559 Campinas, SP, Brazil
dc.descriptionSao Jose Hosp, Beneficencia Portuguesa Sao Paulo, Div Breast Surg, Sao Paulo, Brazil
dc.descriptionEuropean Inst Oncol, Div Plast & Reconstruct Surg, Milan, Italy
dc.descriptionState Univ Sao Paulo Unesp, Botucatu, SP, Brazil
dc.descriptionState Univ Sao Paulo Unesp, Botucatu, SP, Brazil
dc.format159-165
dc.languageeng
dc.publisherWiley-Blackwell
dc.relationBreast Journal
dc.relation2.424
dc.rightsAcesso restrito
dc.sourceWeb of Science
dc.subjectadipocyte stem cell
dc.subjectautologous fat graft
dc.subjectbreast cancer
dc.subjectbreast reconstruction
dc.subjectlocal recurrence
dc.titleOncological Safety of Autologous Fat Grafting after Breast Conservative Treatment: A Prospective Evaluation
dc.typeArtigo


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