3-D Technology Used to Accurately Understand Equine Ileocolonic Aganglionosis

dc.contributorUniv Paranaense
dc.contributorUniversidade de São Paulo (USP)
dc.contributorUniversidade Estadual Paulista (Unesp)
dc.creatorMuniz, Eliane
dc.creatorLobo Ladd, Aliny A. B.
dc.creatorLobo Ladd, Fernando V.
dc.creatorSilva, Andrea A. P. da
dc.creatorKmit, Fernanda V.
dc.creatorBorges, Alexandre Secorun [UNESP]
dc.creatorTeixeira, Raffaella [UNESP]
dc.creatorMota, Ligia S. L. S. da [UNESP]
dc.creatorBelli, Carla B.
dc.creatorZoppa, Andre L. V. de
dc.creatorSilva, Luis C. L. C. da
dc.creatorMelo, Mariana P. de
dc.creatorCoppi, Antonio A.
dc.date2014-12-03T13:08:51Z
dc.date2014-12-03T13:08:51Z
dc.date2013-01-01
dc.date.accessioned2023-09-09T09:46:42Z
dc.date.available2023-09-09T09:46:42Z
dc.identifierhttp://dx.doi.org/10.1159/000353218
dc.identifierCells Tissues Organs. Basel: Karger, v. 198, n. 2, p. 160-168, 2013.
dc.identifier1422-6405
dc.identifierhttp://hdl.handle.net/11449/111637
dc.identifier10.1159/000353218
dc.identifierWOS:000326430200007
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/8761297
dc.descriptionIleocolonic aganglionosis (ICA) is the congenital and hereditary absence of neurons that constitute the enteric nervous system and has been described in various species including humans - Hirschsprung's disease - and horses - overo lethal white syndrome (OLWS). Hirschsprung's disease affects circa 1 in 5,000 live births. At best, this disease means an inability to absorb nutrients from food (humans). At worse, in horses, it always means death. Despite our general understanding of the functional mechanisms underlying ICA, there is a paucity of reliable quantitative information about the structure of myenteric and submucosal neurons in healthy horses and there are no studies on horses with ICA. In light of these uncertainties, we have used design-based stereology to describe the 3-D structure - total number and true size of myenteric and submucosal neurons in the ileum of ICA horses. Our study has shown that ICA affects all submucosal neurons and 99% of nnyenteric neurons. The remaining myenteric neurons (0.56%) atrophy immensely, i.e. 63.8%. We believe this study forms the basis for further research, assessing which subpopulation of myenteric neurons are affected by ileocolonic aganglionosis, and we would like to propose a new nomenclature to distinguish between a complete absence of neurons aganglionosis and a weaker form of the disease which we suggest naming 'hypoganglionosis'. Our results are a step forward in understanding this disease structurally. (C) 2013 S. Karger AG, Basel
dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.descriptionUniv Paranaense, Lab Expt Neurogastroenterol, Umuarama, Brazil
dc.descriptionUniv Sao Paulo, Coll Vet Med & Anim Sci, Lab Stochast Stereol & Chem Anat, Dept Surg, BR-05508270 Sao Paulo, Brazil
dc.descriptionUniv Sao Paulo, Coll Vet Med & Anim Sci, Dept Internal Med, BR-05508270 Sao Paulo, Brazil
dc.descriptionUniv Sao Paulo, Coll Vet Med & Anim Sci, Dept Surg, BR-05508270 Sao Paulo, Brazil
dc.descriptionUniv Estadual Paulista, Coll Vet Med & Anim Sci, Dept Vet Clin Sci, Sao Paulo, Brazil
dc.descriptionUniv Sao Paulo, Inst Math & Stat, Dept Stat, Sao Paulo, Brazil
dc.descriptionUniv Estadual Paulista, Coll Vet Med & Anim Sci, Dept Vet Clin Sci, Sao Paulo, Brazil
dc.descriptionFAPESP: 07/50168-4
dc.format160-168
dc.languageeng
dc.publisherKarger
dc.relationCells Tissues Organs
dc.relation1.275
dc.relation0,572
dc.rightsAcesso restrito
dc.sourceWeb of Science
dc.subjectIleocolonic aganglionosis
dc.subjectOvero lethal white syndrome
dc.subjectMyenteric plexus
dc.subjectSubmucosal plexus
dc.subjectHorses
dc.subjectStereology
dc.title3-D Technology Used to Accurately Understand Equine Ileocolonic Aganglionosis
dc.typeArtigo


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