Luminescent threat: toxicity of light stick attractors used in pelagic fishery

dc.contributorUniversidade de São Paulo (USP)
dc.contributorUniversidade Estadual Paulista (Unesp)
dc.contributorGlobal Garbage
dc.contributorUniversidade Federal de São Paulo (UNIFESP)
dc.creatorOliveira, Tiago Franco de
dc.creatorMedeiros da Silva, Amanda Lucila
dc.creatorMoura, Rafaela Alves de
dc.creatorBagattini, Raquel [UNESP]
dc.creatorFalcao de Oliveira, Antonio Anax
dc.creatorGennari de Medeiros, Marisa Helena
dc.creatorDi Mascio, Paolo
dc.creatorArruda Campos, Ivan Persio de [UNESP]
dc.creatorBarretto, Fabiano Prado
dc.creatorHenriques Bechara, Etelvino Jose
dc.creatorMelo Loureiro, Ana Paula de
dc.date2014-12-03T13:08:50Z
dc.date2014-12-03T13:08:50Z
dc.date2014-06-19
dc.date.accessioned2023-09-09T09:46:20Z
dc.date.available2023-09-09T09:46:20Z
dc.identifierhttp://dx.doi.org/10.1038/srep05359
dc.identifierScientific Reports. London: Nature Publishing Group, v. 4, 11 p., 2014.
dc.identifier2045-2322
dc.identifierhttp://hdl.handle.net/11449/111615
dc.identifier10.1038/srep05359
dc.identifierWOS:000337499400008
dc.identifierWOS000337499400008.pdf
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/8761277
dc.descriptionLight sticks (LS) are sources of chemiluminescence commonly used in pelagic fishery, where hundreds are discarded and reach the shores. Residents from fishing villages report an improper use of LS contents on the skin. Given the scarce information regarding LS toxicity, the effects of LS solutions in cell cultures were evaluated herein. Loss of viability, cell cycle changes and DNA fragmentation were observed in HepG2 cell line and skin fibroblasts. A non-cytotoxic LS concentration increased the occurrence of the mutagenic lesion 1,N-6-epsilon dAdo in HepG2 DNA by three-fold. Additionally, in vitro incubations of spent LS contents with DNA generated dGuo-LS adducts, whose structure elucidation revealed the presence of a reactive chlorinated product. In conclusion, the LS contents were found to be highly cyto- and genotoxic. Our data indicate an urgent need for LS waste management guidelines and for adequate information regarding toxic outcomes that may arise from human exposure.
dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.descriptionCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.descriptionConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.descriptionPRPUSP (Pro-Reitoria de Pesquisa da Universidade de Sao Paulo)
dc.descriptionNAP Redoxoma (PRPUSP)
dc.descriptionUniv Sao Paulo, Fac Ciencias Farmaceut, Dept Anal Clin & Toxicol, Sao Paulo, Brazil
dc.descriptionUniv Estadual Paulista, Inst Ciencias & Saude, Sao Paulo, Brazil
dc.descriptionUniv Sao Paulo, Inst Quim, Dept Bioquim, BR-01498 Sao Paulo, Brazil
dc.descriptionUniv Estadual Paulista, Inst Ciencias Exatas & Tecnol, Sao Paulo, Brazil
dc.descriptionGlobal Garbage, Hamburg, Germany
dc.descriptionUniv Fed Sao Paulo, Dept Ciencias Exatas & Terra, Diadema, SP, Brazil
dc.descriptionUniv Estadual Paulista, Inst Ciencias & Saude, Sao Paulo, Brazil
dc.descriptionUniv Estadual Paulista, Inst Ciencias Exatas & Tecnol, Sao Paulo, Brazil
dc.descriptionFAPESP: 12/21636-8, 2012/08617-4
dc.descriptionFAPESP: 06/56530-4
dc.descriptionFAPESP: 06/57929-8
dc.descriptionFAPESP: 09/54816-6
dc.descriptionFAPESP: 12/08616-8
dc.descriptionFAPESP: 573530/2008-4
dc.descriptionNAP Redoxoma (PRPUSP)2011.1.9352.1.8
dc.descriptionFAPESP: 13/07937-8
dc.format11
dc.languageeng
dc.publisherNature Publishing Group
dc.relationScientific Reports
dc.relation4.122
dc.relation1,533
dc.rightsAcesso restrito
dc.sourceWeb of Science
dc.titleLuminescent threat: toxicity of light stick attractors used in pelagic fishery
dc.typeArtigo


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