Ancient Dispersal of the Human Fungal Pathogen Cryptococcus gattii from the Amazon Rainforest

dc.contributorCBS KNAW Fungal Biodivers Ctr
dc.contributorCanisius Wilhelmina Hosp
dc.contributorUniversidade Estadual Paulista (Unesp)
dc.contributorHadassah Hebrew Univ Med Ctr
dc.contributorUniv Birmingham
dc.contributorUniv Ghent
dc.contributorCtr Genom Regulat
dc.contributorUPF Doctor Aiguader
dc.contributorNetherlands Inst Ecol NIOO KNAW
dc.contributorCtr Wiskunde & Informat
dc.contributorVrije Univ Amsterdam
dc.contributorUniv British Columbia
dc.contributorInst Nacl Salud
dc.contributorFiocruz MS
dc.contributorUniv Sydney
dc.contributorRadboud Univ Nijmegen
dc.contributorSecond Mil Med Univ
dc.contributorUniv Med Ctr
dc.creatorHagen, Ferry
dc.creatorCeresini, Paulo C. [UNESP]
dc.creatorPolacheck, Itzhack
dc.creatorMa, Hansong
dc.creatorvan Nieuwerburgh, Filip
dc.creatorGabaldon, Toni
dc.creatorKagan, Sarah
dc.creatorPursall, E. Rhiannon
dc.creatorHoogveld, Hans L.
dc.creatorvan Iersel, Leo J. J.
dc.creatorKlau, Gunnar W.
dc.creatorKelk, Steven M.
dc.creatorStougie, Leen
dc.creatorBartlett, Karen H.
dc.creatorVoelz, Kerstin
dc.creatorPryszcz, Leszek P.
dc.creatorCastaneda, Elizabeth
dc.creatorLazera, Marcia
dc.creatorMeyer, Wieland
dc.creatorDeforce, Dieter
dc.creatorMeis, Jacques F.
dc.creatorMay, Robin C.
dc.creatorKlaassen, Corne H. W.
dc.creatorBoekhout, Teun
dc.date2014-12-03T13:08:43Z
dc.date2014-12-03T13:08:43Z
dc.date2013-08-07
dc.date.accessioned2023-09-09T09:44:41Z
dc.date.available2023-09-09T09:44:41Z
dc.identifierhttp://dx.doi.org/10.1371/journal.pone.0071148
dc.identifierPlos One. San Francisco: Public Library Science, v. 8, n. 8, 14 p., 2013.
dc.identifier1932-6203
dc.identifierhttp://hdl.handle.net/11449/111514
dc.identifier10.1371/journal.pone.0071148
dc.identifierWOS:000323109700082
dc.identifierWOS000323109700082.pdf
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/8761185
dc.descriptionOver the past two decades, several fungal outbreaks have occurred, including the high-profile 'Vancouver Island' and 'Pacific Northwest' outbreaks, caused by Cryptococcus gattii, which has affected hundreds of otherwise healthy humans and animals. Over the same time period, C. gattii was the cause of several additional case clusters at localities outside of the tropical and subtropical climate zones where the species normally occurs. In every case, the causative agent belongs to a previously rare genotype of C. gattii called AFLP6/VGII, but the origin of the outbreak clades remains enigmatic. Here we used phylogenetic and recombination analyses, based on AFLP and multiple MLST datasets, and coalescence gene genealogy to demonstrate that these outbreaks have arisen from a highly-recombining C. gattii population in the native rainforest of Northern Brazil. Thus the modern virulent C. gattii AFLP6/VGII outbreak lineages derived from mating events in South America and then dispersed to temperate regions where they cause serious infections in humans and animals.
dc.descriptionNPRP grant from the Qatar National Research Fund (a member of Qatar foundation)
dc.descriptionNCF (Netherlands Computer Facility Foundation)
dc.descriptionNWO (Nederlandse Organisatie voor Wetenschappelijk Onderzoek)
dc.descriptionOdo van Vloten Foundation
dc.descriptionCBS KNAW Fungal Biodivers Ctr, Dept Yeast & Basidiomycete Res, Utrecht, Netherlands
dc.descriptionCanisius Wilhelmina Hosp, Dept Med Microbiol & Infect Dis, Nijmegen, Netherlands
dc.descriptionUniv Sao Paulo State, Dept Phytopathol, UNESP, Ilha Solteira, Brazil
dc.descriptionHadassah Hebrew Univ Med Ctr, Dept Clin Microbiol & Infect Dis, Jerusalem, Israel
dc.descriptionUniv Birmingham, Sch Biosci, Birmingham, W Midlands, England
dc.descriptionUniv Ghent, Fac Pharmaceut Sci, Lab Pharmaceut Biotechnol, B-9000 Ghent, Belgium
dc.descriptionCtr Genom Regulat, Barcelona, Spain
dc.descriptionUPF Doctor Aiguader, Barcelona, Spain
dc.descriptionNetherlands Inst Ecol NIOO KNAW, Ctr Limnol, Wageningen, Netherlands
dc.descriptionCtr Wiskunde & Informat, Amsterdam, Netherlands
dc.descriptionVrije Univ Amsterdam, Dept Operat Res, Amsterdam, Netherlands
dc.descriptionUniv British Columbia, Sch Environm Hlth, Vancouver, BC V5Z 1M9, Canada
dc.descriptionInst Nacl Salud, Microbiol Grp, Bogota, Colombia
dc.descriptionFiocruz MS, Fundacao Oswaldo Cruz, Lab Micol, Inst Pesquisa Clin Evandro Chagas, BR-21045900 Rio De Janeiro, Brazil
dc.descriptionUniv Sydney, Westmead Hosp, Ctr Infect Dis & Microbiol,Sydney Emerging Dis &, Mol Mycol Res Lab,Westmead Millennium Inst,Sydney, Westmead, NSW 2145, Australia
dc.descriptionRadboud Univ Nijmegen, Med Ctr, Dept Med Microbiol, NL-6525 ED Nijmegen, Netherlands
dc.descriptionSecond Mil Med Univ, Changzheng Hosp, Shanghai Key Lab Mol Med Mycol, Shanghai, Peoples R China
dc.descriptionUniv Med Ctr, Dept Internal Med & Infect Dis, Utrecht, Netherlands
dc.descriptionUniv Sao Paulo State, Dept Phytopathol, UNESP, Ilha Solteira, Brazil
dc.descriptionNPRP grant from the Qatar National Research Fund (a member of Qatar foundation)5-298-3-06
dc.format14
dc.languageeng
dc.publisherPublic Library Science
dc.relationPLOS ONE
dc.relation2.766
dc.relation1,164
dc.rightsAcesso aberto
dc.sourceWeb of Science
dc.titleAncient Dispersal of the Human Fungal Pathogen Cryptococcus gattii from the Amazon Rainforest
dc.typeArtigo


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