AIDS-related lymphoma in Brazil - Histopathology, immunophenotype, and association with Epstein-Barr virus

dc.contributorUniversidade Estadual Paulista (UNESP)
dc.creatorBacchi, C. E.
dc.creatorBacchi, M. M.
dc.creatorRabenhorst, S. H.
dc.creatorSoares, F. A.
dc.creatorFonseca, L. E.
dc.creatorBarbosa, H. S.
dc.creatorWeiss, L. M.
dc.creatorGown, A. M.
dc.date2014-05-20T15:20:14Z
dc.date2016-10-25T17:53:18Z
dc.date2014-05-20T15:20:14Z
dc.date2016-10-25T17:53:18Z
dc.date1996-02-01
dc.date.accessioned2017-04-05T23:24:41Z
dc.date.available2017-04-05T23:24:41Z
dc.identifierAmerican Journal of Clinical Pathology. Philadelphia: Lippincott-raven Publ, v. 105, n. 2, p. 230-237, 1996.
dc.identifier0002-9173
dc.identifierhttp://hdl.handle.net/11449/31567
dc.identifierhttp://acervodigital.unesp.br/handle/11449/31567
dc.identifierWOS:A1996TU71600017
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/876087
dc.descriptionThe occurrence of malignant lymphoma is an increasingly important cause of morbidity and mortality in AIDS patients. The incidence of AIDS-related lymphoma in some developing countries such as Brazil is increasing as the survival of HIV infection has improved. Although there is a clear association between several types of immunodeficiency related lymphomas and Epstein-Barr virus (EBV), the association of EBV infection in AIDS-related lymphoma in Brazil, where the incidence of AIDS is high, is unknown. Formalin-fixed, paraffin-embedded tissue from 24 cases of AIDS-related lymphoma in Brazil were analyzed for morphologic classification, immunophenotype, and EBV association using in situ hybridization studies with an EBV-EBER1 biotinylated probe. Twenty cases of AIDS-related lymphoma were classified as non-Hodgkin's lymphoma and four cases were Hodgkin's disease. Eleven non-Hodgkin's lymphomas were classified as diffuse large cell type, five cases were small non-cleaved cell, Burkitt-type, and four cases were large cell immunoblastic non-Hodgkin's lymphoma. Eighteen cases were of B-cell phenotype; one was a T-cell lymphoma, and one was classified as null. Epstein-Barr virus (EBV) was demonstrated in the majority of tumor cells of 11 of 20 (55%) of the cases non-Hodgkin's lymphomas and in 3 of 4 (75%) cases of Hodgkin's disease. AIDS-related lymphomas in Brazil are usually of large cell/immunoblastic type, but Hodgkin's disease is also seen. Both non-Hodgkin's lymphoma and Hodgkin's disease are often associated with EBV infection. The non-Hodgkin's lymphoma is predominantly of B-cell phenotype.
dc.languageeng
dc.publisherLippincott-raven Publ
dc.relationAmerican Journal of Clinical Pathology
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectAIDS
dc.subjectHIV
dc.subjectEBV
dc.subjectimmunohistochemistry
dc.subjectlymphoma
dc.subjectHodgkin's disease
dc.subjectin situ hybridization
dc.titleAIDS-related lymphoma in Brazil - Histopathology, immunophenotype, and association with Epstein-Barr virus
dc.typeOtro


Este ítem pertenece a la siguiente institución