NOVEL PREDICTORS OF PERITONITIS-RELATED OUTCOMES IN THE BRAZPD COHORT

dc.contributorPontifícia Universidade Católica do Paraná (PUCPR)
dc.contributorUniversidade Estadual Paulista (Unesp)
dc.contributorUniversidade Federal de Juiz de Fora (UFJF)
dc.contributorKarolinska Inst
dc.creatorProenca de Moraes, Thyago
dc.creatorOlandoski, Marcia
dc.creatorCaramori, Jaqueline C. T. [UNESP]
dc.creatorMartin, Luis Cuadrado [UNESP]
dc.creatorFernandes, Natalia
dc.creatorCarolino Divino-Filho, Jose
dc.creatorPecoits-Filho, Roberto
dc.creatorBarretti, Pasqual [UNESP]
dc.creatorBRAZPD Study Grp
dc.date2014-12-03T13:07:01Z
dc.date2014-12-03T13:07:01Z
dc.date2014-03-01
dc.date.accessioned2023-09-09T09:34:18Z
dc.date.available2023-09-09T09:34:18Z
dc.identifierhttp://dx.doi.org/10.3747/pdi.2012.00333
dc.identifierPeritoneal Dialysis International. Toronto: Multimed Inc, v. 34, n. 2, p. 179-187, 2014.
dc.identifier0896-8608
dc.identifierhttp://hdl.handle.net/11449/111168
dc.identifier10.3747/pdi.2012.00333
dc.identifierWOS:000336083400007
dc.identifier5496411983893479
dc.identifier4923203168446615
dc.identifier0000-0003-4979-4836
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/8760851
dc.descriptionIntroduction: Peritonitis remains the main cause of peritoneal dialysis (PD) technique failure worldwide, despite significant reductions in infection rates observed over the past decades. Several studies have described risk factors for peritonitis, technique failure and mortality. However, there are scarce data regarding predictors of complications during and after a peritonitis episode. The aim of our study was to analyze predictors of peritonitis-related outcome in the Brazilian Peritoneal Dialysis study (BRAZPD) cohort.Methods: All adult incident patients recruited in the BRAZPD Study between December 2004 and October 2007, who remained at least 90 days on PD and presented their first peritonitis episode (n = 474 patients) were included in the study. The endpoints analyzed were non-resolution, death due to a peritonitis episode and long-term technique survival after a peritonitis episode.Results: In the multivariable regression, non-resolution was independently associated with older age (odds ratio (OR) 1.02; p < 0.01), collagenosis as the primary renal disease (OR 4.6; p < 0.05) and Pseudomonas spp as etiological agent (OR 2.9; p < 0.05). Patients who were transferred from APD to CAPD during peritonitis therapy presented a higher risk of non-response (OR 2.5; p < 0.05). The only factor associated with death during a peritonitis episode was older age (OR 1.04; p < 0.05). Exposure to vancomycin and male gender were the independent predictors of long-term technique failure (OR 2.2; p < 0.01).Conclusion: Apart from confirming previous observations of the negative impact of older age and Pseudomonas spp peritonitis on outcomes, we observed that collagenosis may negatively impact response to treatment and exposure to vancomycin may possibly reduce long-term technique survival. It is important to emphasize that the association of vancomycin with technique failure does not prove causality. These findings shed light on new factors predicting outcome when peritonitis is diagnosed.
dc.descriptionBaxter Healthcare
dc.descriptionPontificia Univ Catolica Parana PUCPR, Sch Med, Curitiba, Parana, Brazil
dc.descriptionUNESP, Botucatu, SP, Brazil
dc.descriptionUniv Fed Juiz de Fora, Juiz De Fora, Brazil
dc.descriptionKarolinska Inst, CLINTEC, Div Renal Med, Stockholm, Sweden
dc.descriptionUNESP, Botucatu, SP, Brazil
dc.format179-187
dc.languageeng
dc.publisherMultimed Inc
dc.relationPeritoneal Dialysis International
dc.relation2.009
dc.relation1,089
dc.rightsAcesso restrito
dc.sourceWeb of Science
dc.subjectPeritoneal dialysis
dc.subjectperitonitis
dc.subjectBRAZPD
dc.subjectclinical outcomes
dc.titleNOVEL PREDICTORS OF PERITONITIS-RELATED OUTCOMES IN THE BRAZPD COHORT
dc.typeArtigo


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