Possible adverse drug events leading to hospital admission in a Brazilian teaching hospital

dc.contributorUniversidade Estadual Paulista (Unesp)
dc.contributorMinisterio da Saude Comissao Nacional de Incorporacao de Tecnologias
dc.creatorVarallo, Fabiana Rossi
dc.creatorCapucho, Helaine Carneiro
dc.creatorDa Silva Planeta, Cleopatra
dc.creatorDe Carvalho Mastroianni, Patricia
dc.date2014-10-01T13:08:56Z
dc.date2014-10-01T13:08:56Z
dc.date2014-03-01
dc.date.accessioned2023-09-09T09:19:32Z
dc.date.available2023-09-09T09:19:32Z
dc.identifierhttp://dx.doi.org/10.6061/clinics/2014(03)03
dc.identifierClinics. Faculdade de Medicina / USP, v. 69, n. 3, p. 163-167, 2014.
dc.identifier1807-5932
dc.identifierhttp://hdl.handle.net/11449/110223
dc.identifier10.6061/clinics/2014(03)03
dc.identifierS1807-59322014000300163
dc.identifierWOS:000333034000003
dc.identifierS1807-59322014000300163.pdf
dc.identifier2514762545280942
dc.identifier0000-0002-1378-6327
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/8759922
dc.descriptionOBJECTIVES: Drug safety problems can lead to hospital admission. In Brazil, the prevalence of hospitalization due to adverse drug events is unknown. This study aims to estimate the prevalence of hospitalization due to adverse drug events and to identify the drugs, the adverse drug events, and the risk factors associated with hospital admissions. METHOD: A cross-sectional study was performed in the internal medicine ward of a teaching hospital in São Paulo State, Brazil, from August to December 2008. All patients aged ≥18 years with a length of stay ≥24 hours were interviewed about the drugs used prior to hospital admission and their symptoms/complaints/causes of hospitalization. RESULTS: In total, 248 patients were considered eligible. The prevalence of hospitalization due to potential adverse drug events in the ward was 46.4%. Overprescribed drugs and those indicated for prophylactic treatments were frequently associated with possible adverse drug events. Frequently reported symptoms were breathlessness (15.2%), fatigue (12.3%), and chest pain (9.0%). Polypharmacy was a risk factor for the occurrence of possible adverse drug events. CONCLUSION: Possible adverse drug events led to hospitalization in a high-complexity hospital, mainly in polymedicated patients. The clinical outcomes of adverse drug events are nonspecific, which delays treatment, hinders causality analysis, and contributes to the underreporting of cases.
dc.descriptionUniversidade Estadual Paulista Julio de Mesquita Filho School of Pharmaceutical Sciences Department of Drugs and Medications
dc.descriptionMinisterio da Saude Comissao Nacional de Incorporacao de Tecnologias
dc.descriptionUniversidade Estadual Paulista Julio de Mesquita Filho School of Pharmaceutical Sciences Department of Natural Active Principles and Toxicology
dc.descriptionUniversidade Estadual Paulista Julio de Mesquita Filho School of Pharmaceutical Sciences Department of Drugs and Medications
dc.descriptionUniversidade Estadual Paulista Julio de Mesquita Filho School of Pharmaceutical Sciences Department of Natural Active Principles and Toxicology
dc.format163-167
dc.languageeng
dc.publisherUniversidade de São Paulo (USP), Faculdade de Medicina
dc.relationClinics
dc.relation1.245
dc.relation0,536
dc.rightsAcesso aberto
dc.sourceSciELO
dc.subjectAdverse Drug Reaction Reporting Systems
dc.subjectProduct Surveillance
dc.subjectPostmarketing
dc.subjectPharmacovigilance
dc.subjectAdmitting Department
dc.subjectHospital
dc.titlePossible adverse drug events leading to hospital admission in a Brazilian teaching hospital
dc.typeArtigo


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