| dc.contributor | Universidade Estadual Paulista (UNESP) | |
| dc.creator | Garcia, M. | |
| dc.creator | Sertorio, S. P. | |
| dc.creator | Alves, G. J. | |
| dc.creator | Chate, S. C. | |
| dc.creator | Carneiro, R. | |
| dc.creator | Lallo, M. A. | |
| dc.date | 2014-05-20T15:20:04Z | |
| dc.date | 2016-10-25T17:53:05Z | |
| dc.date | 2014-05-20T15:20:04Z | |
| dc.date | 2016-10-25T17:53:05Z | |
| dc.date | 2004-07-01 | |
| dc.date.accessioned | 2017-04-05T23:23:42Z | |
| dc.date.available | 2017-04-05T23:23:42Z | |
| dc.identifier | Pesquisa Veterinaria Brasileira. Rio Janeiro: Revista Pesquisa Veterinaria Brasileira, v. 24, n. 3, p. 115-119, 2004. | |
| dc.identifier | 0100-736X | |
| dc.identifier | http://hdl.handle.net/11449/31425 | |
| dc.identifier | http://acervodigital.unesp.br/handle/11449/31425 | |
| dc.identifier | 10.1590/S0100-736X2004000300001 | |
| dc.identifier | S0100-736X2004000300001 | |
| dc.identifier | WOS:000225468400001 | |
| dc.identifier | WOS000225468400001.pdf | |
| dc.identifier | http://dx.doi.org/10.1590/S0100-736X2004000300001 | |
| dc.identifier.uri | http://repositorioslatinoamericanos.uchile.cl/handle/2250/875972 | |
| dc.description | Cyclophosphamide (CY) was used to evaluate the effect on the immune system of sheep. Castred adult rams were divided into 3 groups, with 6 animals each one. Group I (day 0) and Group II (day 1) were treated with CY (40 mg/kg, single dose, IV), and Group III was not treated and remained as control. All groups were immunized on day 0 with B19 brucellosis vaccine. on day 6, all animals were bled and serum agglutination test for brucellosis antibodies detection was performed. During 7 days blood lymphocyte counts and electrophoresis gammaglobulin dosage were daily performed. The results showed statistical decrease of immune response. Low serum titers of brucellosis antibodies were found in Groups I and II, and lymphopenia and hypogammaglobulinemia were also found in these groups. A high mortality rate (40%) occurred in the treated animals. | |
| dc.language | por | |
| dc.publisher | Revista Pesquisa Veterinaria Brasileira | |
| dc.relation | Pesquisa Veterinária Brasileira | |
| dc.rights | info:eu-repo/semantics/openAccess | |
| dc.subject | immunosupression | |
| dc.subject | cyclophosfamide | |
| dc.subject | immunology | |
| dc.subject | sheep | |
| dc.title | Uso da ciclofosfamida em modelo de imunodepressão experimental em ovinos | |
| dc.type | Otro | |
