Nonsteroidal anti-inflammatory therapy: changes on renal function of healthy dogs

dc.contributorUniversity of Oeste Paulista Postgraduate Program in Animal Sciences
dc.contributorUniversidade do Oeste Paulista (UNOESTE)
dc.contributorUniversidade Estadual Paulista (Unesp)
dc.contributorUniversity Center of Rio Preto
dc.creatorBorges, Marina
dc.creatorMarini Filho, Rivaldo
dc.creatorLaposy, Cecília Braga
dc.creatorGuimarães-Okamoto, Priscylla Tatiana Chalfun [UNESP]
dc.creatorChaves, Marina Platzeck
dc.creatorVieira, André Nanny Le Sueur
dc.creatorMelchert, Alessandra [UNESP]
dc.date2014-09-30T18:18:26Z
dc.date2014-09-30T18:18:26Z
dc.date2013-12-01
dc.date.accessioned2023-09-09T09:08:47Z
dc.date.available2023-09-09T09:08:47Z
dc.identifierhttp://dx.doi.org/10.1590/S0102-86502013001200006
dc.identifierActa Cirurgica Brasileira. Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia, v. 28, n. 12, p. 842-847, 2013.
dc.identifier0102-8650
dc.identifierhttp://hdl.handle.net/11449/109538
dc.identifier10.1590/S0102-86502013001200006
dc.identifierS0102-86502013001200006
dc.identifierWOS:000328649900006
dc.identifierS0102-86502013001200006.pdf
dc.identifier5085484980214125
dc.identifier0000-0003-1944-2426
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/8759260
dc.descriptionPURPOSE: To evaluate the renal function in healthy dogs submitted to nonselective and preferential COX-2 nonsteroidal anti-inflammatory drug (NSAID) therapy. METHODS: Twenty four healthy dogs were distributed into four groups (G) (n=6): ketoprofenG - treated with ketoprofen; nimesulideG - treated with nimesulid; meloxicanG - treated with meloxican; and etodolacG - treated with etodolaco. All the dogs received the NSAIDs for 10 days by oral route. Physical examination and renal function (urinalysis, urinary sodium and gamma-glutamyl transpeptidase (GGT), serum urea, creatinine, potassium and sodium, and endogenous creatinine clearance) were evaluated before, after five and ten days (T0, T5 and T10) of the treatment in all groups. RESULTS: Changes were observed in urinalysis, with a significant increase in renal cells in the urine at T5 and T10 in nimesulideG. Significant reduction in urinary sodium in nimesulideG at T5 was observed. The clearance values were lower in ketoprofenG at T10. CONCLUSIONS: Meloxicam and etodolac were the drugs that have proven to be safer for short-term therapy in healthy dogs in relation to renal function. NSAIDs ketoprofen and nimesulide should be used judiciously in dogs with renal dysfunction, since there are promoted changes in renal function.
dc.descriptionUNOESTE
dc.descriptionUniversity of Oeste Paulista Postgraduate Program in Animal Sciences
dc.descriptionUNOESTE
dc.descriptionSao Paulo State University Department of Veterinary Clinic
dc.descriptionUniversity Center of Rio Preto
dc.descriptionUNESP Department of Veterinary Clinic
dc.descriptionSao Paulo State University Department of Veterinary Clinic
dc.descriptionUNESP Department of Veterinary Clinic
dc.format842-847
dc.languageeng
dc.publisherSociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia
dc.relationActa Cirúrgica Brasileira
dc.relation0.933
dc.relation0,395
dc.rightsAcesso aberto
dc.sourceSciELO
dc.subjectAnti-Inflammatory Agents, Non-Steroidal
dc.subjectDrug Effects
dc.subjectKidney
dc.subjectDogs
dc.titleNonsteroidal anti-inflammatory therapy: changes on renal function of healthy dogs
dc.typeArtigo


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