Antiproliferative effect of Pterogyne nitens on melanoma cells

dc.contributorUniversidade Estadual Paulista (Unesp)
dc.contributorInstituto de Botânica, São Paulo
dc.contributorInstituto Butantan
dc.contributorUniversidade Federal do Rio de Janeiro (UFRJ)
dc.creatorRegasini, L. O. [UNESP]
dc.creatorLopes,, A. A. [UNESP]
dc.creatorSilva, D. H.S. [UNESP]
dc.creatorFurlan, Maysa [UNESP]
dc.creatorYoung, M. C.M.
dc.creatorMaria, D. A.
dc.creatorBarreiro,, E. J.
dc.creatorBolzani, Vanderlan da Silva [UNESP]
dc.date2014-06-24T19:53:46Z
dc.date2014-06-24T19:53:46Z
dc.date2007
dc.date.accessioned2023-09-09T08:33:41Z
dc.date.available2023-09-09T08:33:41Z
dc.identifierhttp://serv-bib.fcfar.unesp.br/seer/index.php/Cien_Farm/article/view/252
dc.identifierRevista de Ciências Farmacêuticas Básica e Aplicada, v. 28, n. 3, 2007, p. 335-340.
dc.identifier1808-4532
dc.identifier2179-443X
dc.identifierhttp://hdl.handle.net/11449/106970
dc.identifier2-s2.0-50049089104
dc.identifierISSN1808-4532-2007-28-3-335-340.pdf
dc.identifier1308042794786872
dc.identifier4484083685251673
dc.identifier4702004904231248
dc.identifier0000-0002-1516-7765
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/8757009
dc.descriptionAs part of our program of bioprospecting for novel antitumor drug prototypes, twenty extracts and fractions obtained from Pterogyne nitens Tul. (Fabaceae, Caesalpinioideae) were screened for antiproliferative activity against B16F10 murine melanoma cells, by the MTT colorimetric assay. The strongest activity was found in EtOAc fractions from the flowers (IC50 = 0.35 µg/mL), fruits (IC50 = 0.34 µg/mL), leaves (IC50 = 0.33 µg/mL) and stems (IC50 = 0.29 µg/mL). Analysis by TLC and HPLC-DAD showed the presence of guanidine alkaloids, flavones and flavonols in the bioactive samples. Additionally, a phytochemical study of the EtOAc fraction of the stems afforded quercetin (1) and isoquercitrin (2), two flavonols with antiproliferative activity previously described in the literature. On the basis of these results, it can be concluded that P. nitens inhibits the growth of melanoma cells in vitro. Further investigations will be needed to assess the usefulness of the samples under study for the treatment of neoplasms and to characterize other bioactive compounds. Keywords: antiproliferative; Pterogyne nitens; Caesalpinioideae; melanoma; flavonoids; Fabaceae.
dc.descriptionDepartamento de Química Orgânica, NuBBE, Instituto de Química, Universidade Estadual Paulista, UNESP, Araraquara, SP, Brasil.
dc.descriptionSeção de Fisiologia e Bioquímica de Plantas, Instituto de Botânica, São Paulo, SP, Brasil.
dc.descriptionServiço de Bioquímica, Divisão de Ciências Fisiológicas e Químicas, Instituto Butantan, São Paulo, SP, Brasil.
dc.descriptionFaculdade de Farmácia, LASSBio, Universidade Federal do Rio de Janeiro, UFRJ, Rio de Janeiro, RJ, Brasil.
dc.descriptionDepartamento de Química Orgânica, NuBBE, Instituto de Química, Universidade Estadual Paulista, UNESP, Araraquara, SP, Brasil.
dc.languageeng
dc.publisherUniversidade Estadual Paulista (Unesp)
dc.relationRevista de Ciências Farmacêuticas Básica e Aplicada
dc.relation0,131
dc.rightsAcesso aberto
dc.sourceRevista de Ciências Farmacêuticas Básica e Aplicada
dc.subjectCiências Farmacêuticas
dc.subjectFarmácia
dc.subjectFarmacologia
dc.subjectToxicologia
dc.subjectBotânica médica
dc.subjectPlantas medicinais
dc.subjectAtenção Farmacêutica
dc.subjectAssistência farmacêutica
dc.subjectIndústria Farmacêutica.
dc.subjectantiproliferative
dc.subjectPterogyne nitens
dc.subjectCaesalpinioideae
dc.subjectmelanoma
dc.subjectflavonoids
dc.subjectFabaceae.
dc.subjectMelanona
dc.titleAntiproliferative effect of Pterogyne nitens on melanoma cells
dc.typeArtigo


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