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Evaluation of extracts from Coccoloba mollis using the Salmonella/microsome system and in vivo tests

dc.contributorUniversidade Estadual Paulista (UNESP)
dc.creatorTsuboy, Marcela Stefanini
dc.creatorMarcarini, Juliana Cristina
dc.creatorFerreira, Dalva Trevisan
dc.creatorFerraz, Elisa Raquel Anastácio
dc.creatorChequer, Farah Maria Drumond
dc.creatorOliveira, Danielle Palma de
dc.creatorRibeiro, Lúcia Regina
dc.creatorMantovani, Mário Sérgio
dc.date2014-05-20T15:17:32Z
dc.date2016-10-25T17:51:24Z
dc.date2014-05-20T15:17:32Z
dc.date2016-10-25T17:51:24Z
dc.date2010-01-01
dc.date.accessioned2017-04-05T23:16:33Z
dc.date.available2017-04-05T23:16:33Z
dc.identifierGenetics and Molecular Biology. Sociedade Brasileira de Genética, v. 33, n. 3, p. 542-548, 2010.
dc.identifier1415-4757
dc.identifierhttp://hdl.handle.net/11449/30509
dc.identifierhttp://acervodigital.unesp.br/handle/11449/30509
dc.identifier10.1590/S1415-47572010005000062
dc.identifierS1415-47572010000300027
dc.identifierWOS:000281913300027
dc.identifierS1415-47572010000300027.pdf
dc.identifierhttp://dx.doi.org/10.1590/S1415-47572010005000062
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/875176
dc.descriptionThe common everyday use of medicinal plants is an ancient, and still very widespread practice, whereby the need for studies on their possible toxicity and mutagenic properties. The species Coccoloba mollis has been much used in phytotherapy, mainly in cases involving loss of memory and stress. In order to investigate its genotoxic and mutagenic potential, ethanolic extracts from the leaves and roots underwent Salmonella/microsome assaying (TA98 and TA100 strains, with and without exogenous metabolism - S9), besides comet and micronucleus tests in vivo.There was no significant increase in the number of revertants/plate of Salmonella strains in any of the analyzed root-extract concentrations, although the extract itself was extremely toxic to the Salmonella TA98 strain in the tests carried out with S9 (doses varying from 0.005 to 0.5 µg/plate). on the other hand, the leaf-extract induced mutations in the TA98 strain in the absence of S9 in the highest concentration evaluated, although at very low mutagenic potency (0.004 rev/µg). Furthermore, there was no statistically significant increase in the number of comets and micronuclei, in treatments involving Swiss mice. It was obvious that extracts of Coccoloba mollis, under the described experimental conditions, are not mutagenic.
dc.languageeng
dc.publisherSociedade Brasileira de Genética
dc.relationGenetics and Molecular Biology
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectmedicinal plants
dc.subjectCoccoloba mollis
dc.subjectAmes test
dc.subjectin vivo comet assay
dc.subjectin vivo micronucleus assay
dc.subjectPolygonaceae
dc.titleEvaluation of extracts from Coccoloba mollis using the Salmonella/microsome system and in vivo tests
dc.typeOtro


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