Ginkgo Biloba Extract 761 Reduces the Risk of Progression of Age-Related Macular Degeneration

dc.creatorRamírez-González, Sergio
dc.creatorCasillas-Casillas, Elizabeth
dc.creatorJaramillo-Juárez, Fernando
dc.creatorRincón-Sánchez, Ana Rosa
dc.date2 de mayo de 2022
dc.date9 de agosto de 2022
dc.date2023-06-20T07:00:00Z
dc.date.accessioned2023-09-07T21:55:50Z
dc.date.available2023-09-07T21:55:50Z
dc.identifierhttps://ciencia.lasalle.edu.co/svo/vol20/iss2/7
dc.identifierhttps://ciencia.lasalle.edu.co/cgi/viewcontent.cgi?article=1510&context=svo
dc.identifierhttps://ciencia.lasalle.edu.co/context/svo/article/1510/viewcontent/6.articulo_6_salud_visual_ocular_20_2.pdf
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/8749356
dc.description<p>La degeneración macular relacionada con la edad (AMD) es la principal causa de ceguera. Su desarrollo es poco conocido, pero concentraciones altas de especies reactivas de oxígeno pueden desencadenarla. El objetivo del estudio fue analizar si la acción antioxidante del suplemento dietético ginkgo biloba (EGb-761) retrasa el desarrollo de la AMD. Ensayo clínico hecho en México, con personas mayores de 55 años. Pacientes con AMD recibieron EGb-761: 50 mg/día (n = 26) o 100 mg/día (n = 22), durante 3 meses. Participó un grupo control de 22 personas sanas. Antes y después del tratamiento, se realizaron pruebas oculares funcionales y estructurales y se midió el estrés oxidativo (OS). Se encontraron cambios significativos (P < 0,05) entre el inicio y después del tratamientos con ambas dosis. Sensibilidad al contraste aumentó 16 % y 17 %, las matamorfopsias (integridad de la visión central) 100 % y 95 %; perimetría central (escotomas) disminuyó 93% y 88%; y la hiperpigmentación (autofluorescencia) disminuyó 88% y 89%, respectivamente. Para el OS, la concentración de malondialdehído disminuyó 7,6 % y 8,5 %, y los niveles de glutatión aumentaron 5,3 % y 7,1 %, respectivamente. El EGb-761 tuvo un efecto benéfico sobre AMD. Sugerimos administrar dosis bajas de Gb a adultos mayores con AMD temprana, para reducir o evitar efectos secundarios.</p>
dc.description<p>Age-related macular degeneration (AMD) is the leading cause of blindness. Although its development is poorly understood., high concentrations of reactive oxygen species, maybe trigger it. The aim of this study was to analyze whether the antioxidant action of the dietary supplement Ginkgo biloba (EGb-761) can reduce the progression of AMD. A clinical trial was conducted in Mexico, with people over 55 years of age. AMD patients were treated with EGb-761: 50 mg/day (n = 26) or 100 mg/day (n = 22) for 3 months. A control group with 22 healthy people (without treatment) was included. Before and after treatment, functional and structural ocular tests were performed, and systemic oxidative stress (OS) was measured.Changes between baseline and after the treatment with both doses were significant (P < 0.05). Contrast sensitivity increased 16% and 17%, the number of metamorphopsias (central vision integrity) decreased 100% and 95%; central perimetry (scotoma) decreased 93% and 88%, and hyperpigmentation (autofluorescence) decreased 88% and 89%, respectively. For OS, malondialdehyde concentration decreased 7.6% and 8.5%, and reduced glutathione levels increased 5.3% and 7.1%, respectively. We suggest giving low doses of Gb to older adults with early-stage AMD educe or avoid side effects.</p>
dc.formatapplication/pdf
dc.formate1484
dc.languageeng
dc.publisherUniversidad de La Salle. Ediciones Unisalle
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dc.rightsAcceso abierto
dc.rightshttp://purl.org/coar/access_right/c_abf2
dc.subjectGinkgo biloba; degeneración macular relacionada con la edad; estrés oxidativo; especies reactivas de oxígeno; malondialdehído; EGB-761
dc.subjectGinkgo biloba; age-related macular degeneration; oxidative stress; reactive oxygen species; malondialdehyde; EGB-761
dc.subjectEye Diseases
dc.subjectOptometry
dc.subjectOther Analytical, Diagnostic and Therapeutic Techniques and Equipment
dc.subjectVision Science
dc.titleGinkgo Biloba Extract 761 Reduces the Risk of Progression of Age-Related Macular Degeneration
dc.typeArtículo de investigación
dc.identifier.doihttps://doi.org/10.19052/sv.vol20.iss2.7
dc.type.coarhttp://purl.org/coar/resource_type/c_2df8fbb1
dc.type.redcolhttp://purl.org/redcol/resource_type/ART
dc.type.contentText
dc.type.coarversionVersión publicada
dc.type.coarversionhttp://purl.org/coar/version/c_970fb48d4fbd8a85
dc.identifier.instnameinstname:Universidad de La Salle
dc.identifier.reponamereponame:Ciencia Unisalle
dc.identifier.repo.urlrepourl:https://ciencia.lasalle.edu.co/
dc.relation.ispartofcitationissue2
dc.relation.ispartofcitationvolume20
dc.relation.ispartofjournalCiencia y Tecnología para la Salud Visual y Ocular
dc.title.translatedEl extracto de Ginkgo Biloba 761 reduce el riesgo de la progresión de la generación macular asociada a la edad


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