Leuprolide Acetate, a GnRH Agonist, Holds Up Neurodegeneration in an Experimental Glaucoma Model

dc.creatorEsparza-Leal, Héctor
dc.creatorMartínez-Moreno, Carlos G.
dc.creatorVentura-Juárez, Javier
dc.creatorQuintanar, Jose Luis
dc.date14 de septiembre de 2022
dc.date04 de noviembre de 2022
dc.date2023-04-10T07:00:00Z
dc.date.accessioned2023-09-07T21:55:50Z
dc.date.available2023-09-07T21:55:50Z
dc.identifierhttps://ciencia.lasalle.edu.co/svo/vol20/iss2/4
dc.identifierhttps://ciencia.lasalle.edu.co/cgi/viewcontent.cgi?article=1506&context=svo
dc.identifierhttps://ciencia.lasalle.edu.co/context/svo/article/1506/viewcontent/3.articulo_3_salud_visual_ocular_20_2.pdf
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/8749354
dc.descriptionEl glaucoma es la principal causa de ceguera irreversible en todo el mundo. En resumen, es una neuropatía óptica progresiva multifactorial que se correlaciona con la muerte de las células ganglionares de la retina, trastornos de la cabeza del nervio óptico y desórdenes del campo visual. Recientemente se ha reportado que el acetato de leuprolida tiene propiedades neurotróficas, el objetivo de este trabajo fue determinar si su administración sistémica retrasa el proceso neurodegenerativo en un modelo experimental de glaucoma. Se incluyeron ratas Wistar divididas en tres grupos: 1) un grupo de control, 2) un grupo de glaucoma inducido por ácido hialurónico y 3) un grupo de glaucoma inducido por ácido hialurónico tratado con acetato de leuprolida intramuscular. Las respuestas eléctricas oculares a la luz se registraron mediante electrorretinografía simultánea de campo completo y los ojos se procesaron para el estudio histológico. Los resultados mostraron una mejora en la actividad eléctrica, una recuperación de fibras del nervio óptico, así como una reducción de la astrogliosis reactiva en el grupo tratado con acetato de leuprolida. En definitiva, el acetato de leuprolida es una nueva y potencial alternativa de tratamiento en el glaucoma, ya que frena el proceso neurodegenerativo.
dc.descriptionGlaucoma is the main cause of irreversible blindness worldwide. In short, it is a multifactorial progressive optic neuropathy that correlates with retinal ganglion cell death, optic nerve head disturbances, and visual field disorders. Leuprolide acetate have recently been reported to have neurotrophic properties, the aim of this work was to determine whether it´s systemic administration holds up the neurodegenerative process in an experimental glaucoma model. Wistar rats divided into three groups were included: 1) a control group, 2) a hyaluronic acid-induced glaucoma group, and 3) a hyaluronic acid-induced glaucoma group treated with intramuscular leuprolide acetate. The eye electrical responses to light were recorded by simultaneous full-field electroretinography, and the eyes were processed for histological study. The results showed an improvement in the electrical activity, a recovery of fibers from the optic nerve as well as a reduction of the reactive astrogliosis in the leuprolide acetate treated group. In short, leuprolide acetate is a new potential alternative treatment in glaucoma, as it holds up the neurodegenerative process.
dc.formatapplication/pdf
dc.formate1491
dc.languageeng
dc.publisherUniversidad de La Salle. Ediciones Unisalle
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dc.rightshttp://creativecommons.org/licenses/by-nc/4.0/
dc.rightsAcceso abierto
dc.rightshttp://purl.org/coar/access_right/c_abf2
dc.subjectceguera; baja visión; neurotrófico; regeneración
dc.subjectblindness; low vision; neurotrophic; regeneration
dc.subjectEye Diseases
dc.subjectOptometry
dc.subjectOther Analytical, Diagnostic and Therapeutic Techniques and Equipment
dc.subjectVision Science
dc.titleLeuprolide Acetate, a GnRH Agonist, Holds Up Neurodegeneration in an Experimental Glaucoma Model
dc.typeArtículo de investigación
dc.identifier.doihttps://doi.org/10.19052/sv.vol20.iss2.4
dc.type.coarhttp://purl.org/coar/resource_type/c_2df8fbb1
dc.type.redcolhttp://purl.org/redcol/resource_type/ART
dc.type.contentText
dc.type.coarversionVersión publicada
dc.type.coarversionhttp://purl.org/coar/version/c_970fb48d4fbd8a85
dc.identifier.instnameinstname:Universidad de La Salle
dc.identifier.reponamereponame:Ciencia Unisalle
dc.identifier.repo.urlrepourl:https://ciencia.lasalle.edu.co/
dc.relation.ispartofcitationissue2
dc.relation.ispartofcitationvolume20
dc.relation.ispartofjournalCiencia y Tecnología para la Salud Visual y Ocular
dc.title.translatedAcetato de leuprolida, agonista de la GnRH, retrasa la neurodegeneración en un modelo experimental de glaucoma


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