| dc.contributor | Valero Valdivieso, Manuel Fernando | |
| dc.date.accessioned | 2017-03-03T19:29:18Z | |
| dc.date.accessioned | 2023-09-07T16:25:47Z | |
| dc.date.available | 2017-03-03T19:29:18Z | |
| dc.date.available | 2023-09-07T16:25:47Z | |
| dc.date.created | 2017-03-03T19:29:18Z | |
| dc.date.issued | 2017-03-03 | |
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| dc.identifier | http://hdl.handle.net/10818/29878 | |
| dc.identifier | 263585 | |
| dc.identifier | TE08924 | |
| dc.identifier.uri | https://repositorioslatinoamericanos.uchile.cl/handle/2250/8736791 | |
| dc.description.abstract | En el presente trabajo se evaluaron materiales poliméricos a partir del aceite de higuerilla, por medio de transesterificación se obtuvieron tres variaciones de polioles (183, 196 y 236 mg KOH/g). Los cuales reaccionaron con diisocianato de isoforona para conformar una matriz de poliuretano, adicionalmente se incorporó quitosano en diferentes concentraciones (0, 2.5, 5 y 7.5 %p/p) con el fin de mejorar la viabilidad celular del polímero. El objetivo del estudio se centró en determinar el efecto de la adición de quitosano a la matriz de poliuretano sobre la viabilidad celular y así establecer si la mezcla tiene potencial para ser usada en aplicaciones biomédicas. Se evaluó la viabilidad celular in vitro de los polímeros y de sus extractos por medio del ensayo MTT sobre fibroblastos embrionarios de ratón L-929 (ATCC® CCL-1). Adicionalmente, se estudió una degradación acelerada de éstos en buffer fosfato a una temperatura de 105ºC por 72 horas. Se encontró que el incremento en la funcionalidad del poliol favorece la viabilidad celular y la adición de quitosano no afecta la proliferación celular. Además, se evidenció la resistencia a la degradación con valores menores a 1%. Con base en los resultados obtenidos, se concluyó que los polímeros pueden tener un alto potencial en aplicaciones biomédicas. | |
| dc.language | spa | |
| dc.publisher | Universidad de La Sabana | |
| dc.publisher | Ingeniería Química | |
| dc.publisher | Facultad de Ingeniería | |
| dc.rights | http://creativecommons.org/licenses/by-nc-nd/4.0/ | |
| dc.rights | restrictedAccess | |
| dc.rights | Attribution-NonCommercial-NoDerivatives 4.0 International | |
| dc.source | Universidad de la Sabana | |
| dc.source | Intellectum Repositorio Universidad de la Sabana | |
| dc.subject | Ingeniería química | |
| dc.subject | Fusión nuclear | |
| dc.subject | Compatibilidad -- Pruebas | |
| dc.title | Evaluación de la citotoxicidad de poliuretanos a partir de aceite de higuerilla y quitosano | |
| dc.type | bachelorThesis | |
