dc.date.accessioned | 2023-02-16T17:37:27Z | |
dc.date.accessioned | 2023-09-07T15:50:30Z | |
dc.date.available | 2023-02-16T17:37:27Z | |
dc.date.available | 2023-09-07T15:50:30Z | |
dc.date.created | 2023-02-16T17:37:27Z | |
dc.date.issued | 2021 | |
dc.identifier | 13652044 | |
dc.identifier | https://associationofanaesthetists-publications.onlinelibrary.wiley.com/doi/full/10.1111/anae.15458 | |
dc.identifier | http://hdl.handle.net/10818/53943 | |
dc.identifier | 10.1111/anae.15458 | |
dc.identifier.uri | https://repositorioslatinoamericanos.uchile.cl/handle/2250/8735798 | |
dc.description.abstract | Peri-operative SARS-CoV-2 infection increases postoperative mortality. The aim of this study was to determine the optimal duration of planned delay before surgery in patients who have had SARS-CoV-2 infection. This international, multicentre, prospective cohort study included patients undergoing elective or emergency surgery during October 2020. Surgical patients with pre-operative SARS-CoV-2 infection were compared with those without previous SARS-CoV-2 infection. The primary outcome measure was 30-day postoperative mortality. Logistic regression models were used to calculate adjusted 30-day mortality rates stratified by time from diagnosis of SARS-CoV-2 infection to surgery. Among 140,231 patients (116 countries), 3127 patients (2.2%) had a pre-operative SARS-CoV-2 diagnosis. Adjusted 30-day mortality in patients without SARS-CoV-2 infection was 1.5% (95%CI 1.4–1.5). In patients with a pre-operative SARS-CoV-2 diagnosis, mortality was increased in patients having surgery within 0–2 weeks, 3–4 weeks and 5–6 weeks of the diagnosis (odds ratio (95%CI) 4.1 (3.3–4.8), 3.9 (2.6–5.1) and 3.6 (2.0–5.2), respectively). Surgery performed ≥ 7 weeks after SARS-CoV-2 diagnosis was associated with a similar mortality risk to baseline (odds ratio (95%CI) 1.5 (0.9–2.1)). After a ≥ 7 week delay in undertaking surgery following SARS-CoV-2 infection, patients with ongoing symptoms had a higher mortality than patients whose symptoms had resolved or who had been asymptomatic (6.0% (95%CI 3.2–8.7) vs. 2.4% (95%CI 1.4–3.4) vs. 1.3% (95%CI 0.6–2.0), respectively). Where possible, surgery should be delayed for at least 7 weeks following SARS-CoV-2 infection. Patients with ongoing symptoms ≥ 7 weeks from diagnosis may benefit from further delay. | |
dc.language | eng | |
dc.publisher | Anaesthesia | |
dc.relation | Anaesthesia, 76(6), 748-758. | |
dc.rights | http://creativecommons.org/licenses/by-nc-nd/4.0/ | |
dc.rights | openAccess | |
dc.rights | Attribution-NonCommercial-NoDerivatives 4.0 International | |
dc.source | Universidad de La Sabana | |
dc.source | Intellectum Repositorio Universidad de La Sabana | |
dc.title | Timing of surgery following SARS-CoV-2 infection: an international prospective cohort study | |
dc.type | journal article | |