Genome-Scale Metabolic Reconstruction of the Phaseolus Genus: Insights into Cyanogenesis Metabolism

dc.contributorDuitama Castellanos, Jorge Alexander
dc.contributorGonzález Barrios, Andrés Fernando
dc.contributorChacón Sánchez, María Isabel
dc.contributorGrupo de Diseño de Productos y Procesos (GDPP)
dc.contributorTICSw
dc.creatorDuarte Torres, Erick Nicolas
dc.date.accessioned2023-07-05T15:15:26Z
dc.date.accessioned2023-09-07T02:19:47Z
dc.date.available2023-07-05T15:15:26Z
dc.date.available2023-09-07T02:19:47Z
dc.date.created2023-07-05T15:15:26Z
dc.date.issued2023-06-06
dc.identifierhttp://hdl.handle.net/1992/68132
dc.identifierinstname:Universidad de los Andes
dc.identifierreponame:Repositorio Institucional Séneca
dc.identifierrepourl:https://repositorio.uniandes.edu.co/
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/8729171
dc.description.abstractIn this research, we present the first metabolic reconstruction of the Phaseolus genus, based on Phaseolus vulgaris metabolic data and incorporating cyanogenesis pathways from Phaseolus lunatus. Our model successfully simulates the plant cell metabolism under photoperiod conditions, making it a valuable tool for studying the metabolims of Phaseolus species. Additionally, we conducted a genomic comparison analysis between the two Phaseolus species to gather data for imposing contrainsts, enabling the simulation of linamarin and lotaustralin biosynthesis, both cyanogenic compounds. By studiyng these pathways, we gained insights into the genomic elements and metabolic mechanism responsible for the high production of linamarin in P. lunatus. In addition, we conducted an optimization analyses to identify metabolic differences that could explain the observed overproduction of linamarin compared to lotaustralin in P. lunatus.
dc.languageeng
dc.publisherUniversidad de los Andes
dc.publisherMaestría en Biología Computacional
dc.publisherFacultad de Ciencias
dc.publisherDepartamento de Ciencias Biológicas
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dc.titleGenome-Scale Metabolic Reconstruction of the Phaseolus Genus: Insights into Cyanogenesis Metabolism
dc.typeTrabajo de grado - Maestría


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