Anaerobiosis: a new gamer in phage-host interaction

dc.contributorVives Flórez, Martha Josefina
dc.contributorCelis Ramírez, Adriana Marcela
dc.contributorRodríguez Villamizar, Fernando
dc.contributorCentro de Investigaciones Microbiológicas - CIMIC
dc.creatorHernández Villamizar, Santiago
dc.date.accessioned2023-02-03T15:24:46Z
dc.date.accessioned2023-09-07T02:06:07Z
dc.date.available2023-02-03T15:24:46Z
dc.date.available2023-09-07T02:06:07Z
dc.date.created2023-02-03T15:24:46Z
dc.date.issued2023-02-02
dc.identifierhttp://hdl.handle.net/1992/64595
dc.identifierinstname:Universidad de los Andes
dc.identifierreponame:Repositorio Institucional Séneca
dc.identifierrepourl:https://repositorio.uniandes.edu.co/
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/8728954
dc.description.abstractLa fagoterapia es una alternativa viable para controlar infecciones bacterianas, sin embargo, entender como la bacterias y fagos interactúan dependiendo del ambiente es crucial para tener un tratamiento efectivo. Muchas de las aplicaciones de fagos son realizadas sobre ambientes anaerobios (intestino, heridas), entonces entender el efecto de la falta o limitación de oxígeno en la interacción fago-hospedero se hace necesaria. Desde 1975 no se han publicado investigaciones para elucidar el efecto de la ausencia de oxígeno en el proceso de infección del fago. En este estudio nosotros reportamos este efecto en un modelo Salmonella sp.-fago, dada su importancia como patógeno y contaminante bacteriano en ambiente anaerobios, y el potencial de la fagoterapia para controlarla. Encontramos que el ciclo de replicación viral, la reducción de la población bacteriana por unidad de tiempo, y el desarrollo de resistencia son influenciadas por la anaerobiosis de la siguiente manera: a) el fago es afectado en la longitud de su ciclo de vida y en su capacidad para controlar la población bacteriana; b) se observó que el tamaño celular bacteriano está asociado a la cantidad de proteína FtsZ y que se altera la aparición de resistencia en contra del fago. Asimismo, los resultados de los análisis transcriptómicos sugieren que la infección en condiciones aeróbicas induce metabolismo anaerobio, específicamente nitrato reducción, y hay subexpresión de genes asociados con respiración aeróbica en la bacteria. En la infección anaeróbica no se observó cambios al metabolismo de generación de energía usado por la bacteria en crecimiento anaeróbico, pero sí se evidenció aumento en la transcripción de genes relacionados con el transporte de aceptores de electrones usados en anaerobiosis. Independiente la condición de oxígeno, los resultados mostraron que la mayoría de los genes con expresión diferencial en la infección fueron aquellos clasificados en la categoría de función desconocida o no pudieron ser anotados. Los resultados en conjunto dan un panorama de cómo la ausencia de oxígeno pude afectar la interacción fago-hospedero, y cuyas consecuencias deberían ser consideradas al momento de usar los fagos biotecnologicamente.
dc.languageeng
dc.publisherUniversidad de los Andes
dc.publisherDoctorado en Ciencias - Biología
dc.publisherFacultad de Ciencias
dc.publisherDepartamento de Ciencias Biológicas
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dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 Internacional
dc.rightshttps://repositorio.uniandes.edu.co/static/pdf/aceptacion_uso_es.pdf
dc.rightsinfo:eu-repo/semantics/openAccess
dc.rightshttp://purl.org/coar/access_right/c_abf2
dc.titleAnaerobiosis: a new gamer in phage-host interaction
dc.typeTrabajo de grado - Doctorado


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