Síntesis y caracterización de cálculos renales artificiales, y el estudio del efecto de extractos de Parietaria officinalis sobre su formación y solubilidad

dc.contributorJiménez Díaz, Elizabeth
dc.contributorUribe Ardila, Jesús Alfredo
dc.contributorRomán Ochoa, Yony
dc.contributorGrupo de Investigación en Bioquímica Aplicada
dc.creatorVelásquez Diaz, Sonia Alejandra
dc.date.accessioned2023-08-08T14:12:10Z
dc.date.accessioned2023-09-07T00:57:27Z
dc.date.available2023-08-08T14:12:10Z
dc.date.available2023-09-07T00:57:27Z
dc.date.created2023-08-08T14:12:10Z
dc.date.issued2023-06
dc.identifierhttp://hdl.handle.net/1992/69354
dc.identifierinstname:Universidad de los Andes
dc.identifierreponame:Repositorio Institucional Séneca
dc.identifierrepourl:https://repositorio.uniandes.edu.co/
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/8728017
dc.description.abstractLos cálculos renales son una condición que afectan al 14,8% de la población mundial, causando dolor y heridas en las vías urinarias de quienes los padecen. Estos son depósitos de minerales y sales acidas formados en las vías urinarias que en su mayoría están formadas por: oxalato de calcio monohidratado, ácido úrico, o fosfato de calcio. Los tratamientos conocidos se consideran invasivos, y poseen varios efectos secundarios, por lo que surge la necesidad de evaluar nuevos tratamientos, entre ellos moléculas provenientes de extractos naturales. La Parietaria officinalis es una planta ampliamente estudiada por sus efectos antibacterianos y también es conocida por su efecto diurético siendo utilizada en el tratamiento de infecciones urinarias. Al ser una condición de amplio interés a nivel de salud pública, se propuso y desarrolló un trabajo de tesis, donde se estandarizó la metodología de síntesis y caracterización de cristales de oxalato de calcio monohidratado. Esta caracterización se realizó mediante las técnicas de (DRX) Difracción de Rayos X en polvo, FT-IR, y Raman. Por otra parte, se desarrollaron cinco metodologías de extracción realizadas a la planta Parietaria officinalis, y su caracterización en términos de cuantificación de flavonoides y análisis de carbohidratos. De igual manera se realizaron pruebas de prevención de la formación de cristales de oxalato de calcio en presencia de los cinco extractos, y también pruebas de solubilidad de los cristales de oxalato de calcio con cada extracto. Finalmente, debido a que el 80% de las infecciones urinarias son provocadas por la bacteria gran negativa como E. coli y en menor proporción por bacterias como S. aureus, se realizaron pruebas preliminares de difusión en disco contra estos microorganismos.
dc.languagespa
dc.publisherUniversidad de los Andes
dc.publisherMaestría en Química
dc.publisherFacultad de Ciencias
dc.publisherDepartamento de Química
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dc.rightshttps://repositorio.uniandes.edu.co/static/pdf/aceptacion_uso_es.pdf
dc.rightsinfo:eu-repo/semantics/openAccess
dc.rightshttp://purl.org/coar/access_right/c_abf2
dc.titleSíntesis y caracterización de cálculos renales artificiales, y el estudio del efecto de extractos de Parietaria officinalis sobre su formación y solubilidad
dc.typeTrabajo de grado - Maestría


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