Diseño de formas farmacéuticas orales como rutas para dosificación de Bromhidrato de Galantamina

dc.contributorAlvarez Solano, Oscar Alberto
dc.contributorGonzález Barrios, Andrés Fernando
dc.contributorGrupo de Diseño de Productos y Procesos
dc.creatorSolarte Rodríguez, Sebastián
dc.date.accessioned2023-06-30T18:18:20Z
dc.date.accessioned2023-09-07T00:44:34Z
dc.date.available2023-06-30T18:18:20Z
dc.date.available2023-09-07T00:44:34Z
dc.date.created2023-06-30T18:18:20Z
dc.date.issued2023-05-29
dc.identifierhttp://hdl.handle.net/1992/68035
dc.identifierinstname:Universidad de los Andes
dc.identifierreponame:Repositorio Institucional Séneca
dc.identifierrepourl:https://repositorio.uniandes.edu.co/
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/8727720
dc.description.abstractActualmente, la enfermedad de Alzheimer (EA) es la causa más común de demencia en pacientes de la tercera edad dada su naturaleza neurodegenerativa. Es por esto, que distintos tratamientos se han diseñado con el fin de manejar los síntomas de esta enfermedad. En este trabajo se estudiará la formulación y manufactura formas farmacéuticas orales a base de Galantamina, un medicamento extraído de la familia de plantas Amaryllidaceae la cual se ha venido usando ampliamente para el tratamiento sintomático de la EA. Se inicia por el entendimiento de su funcionamiento y metabolismo, hasta la propuesta de su composición y fabricación a escala laboratorio para su posterior implementación a nivel industrial siguiendo la aproximación de "Quality by Design" (QbD) y el diseño integrado de procesos y productos (DIPP). Para lograr esto, se plantean dos formas farmacéuticas como tabletas y emulsiones en las cuales se evaluará la incidencia de variables de formulación y proceso en respuestas fisicoquímicas y cinéticas de los sistemas formulados.
dc.languagespa
dc.publisherUniversidad de los Andes
dc.publisherMaestría en Ingeniería Química
dc.publisherFacultad de Ingeniería
dc.publisherDepartamento de Ingeniería Química y de Alimentos
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dc.titleDiseño de formas farmacéuticas orales como rutas para dosificación de Bromhidrato de Galantamina
dc.typeTrabajo de grado - Maestría


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