Study of virulence factors in coagulase-negative staphylococci isolated from newborns

dc.contributorUniversidade Estadual Paulista (UNESP)
dc.creatorCunha, Maria de Lourdes Ribeiro de Souza da
dc.creatorRugolo, Ligia Maria Suppo de Souza
dc.creatorLopes, Carlos Alberto de Magalhães
dc.date2014-05-20T15:09:25Z
dc.date2016-10-25T17:43:53Z
dc.date2014-05-20T15:09:25Z
dc.date2016-10-25T17:43:53Z
dc.date2006-09-01
dc.date.accessioned2017-04-05T22:44:48Z
dc.date.available2017-04-05T22:44:48Z
dc.identifierMemórias do Instituto Oswaldo Cruz. Instituto Oswaldo Cruz, Ministério da Saúde, v. 101, n. 6, p. 661-668, 2006.
dc.identifier0074-0276
dc.identifierhttp://hdl.handle.net/11449/27215
dc.identifierhttp://acervodigital.unesp.br/handle/11449/27215
dc.identifier10.1590/S0074-02762006000600014
dc.identifierS0074-02762006000600014
dc.identifierS0074-02762006000600014.pdf
dc.identifierhttp://dx.doi.org/10.1590/S0074-02762006000600014
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/871916
dc.descriptionCoagulase-negative staphylococci (CNS) have been identified as the etiological agent in various infections and are currently the microorganisms most frequently isolated in nosocomial infections. However, little is known about the virulence factors produced by CNS that contribute to the pathogenesis of infections caused by these microorganisms. The study of CNS isolated from infectious processes of newborns hospitalized in the Neonatal Unit of the Hospital of the Botucatu Medical School, Unesp, indicated Staphylococcus epidermidis as the most frequently isolated species (77.8%), which was also associated with clinically significant situations. The analysis of virulence factors revealed the production of slime in 20 (17.1%) of all CNS samples isolated and the synthesis of a broad spectrum of enzymes and toxins, including hemolysins (19.6%), lipase (17.1%), lecithinase (3.4%), DNAse (15.4%), thermonuclease (7.7%), and enterotoxin A, B or C (37.6%). Taking into consideration that the etiological importance of CNS has often been neglected, the present investigation confirmed that these microorganisms should not be ignored or classified as mere contaminants.
dc.languageeng
dc.publisherInstituto Oswaldo Cruz, Ministério da Saúde
dc.relationMemórias do Instituto Oswaldo Cruz
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectcoagulase-negative staphylococci
dc.subjectvirulence factors
dc.subjectslime
dc.subjectenzymes
dc.subjecttoxins
dc.titleStudy of virulence factors in coagulase-negative staphylococci isolated from newborns
dc.typeOtro


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