Serotonin and circadian rhythms

dc.contributorUniversidade Estadual Paulista (UNESP)
dc.creatorPontes, André Luiz Bezerra de
dc.creatorEngelberth, Rovena Clara Galvão Januário
dc.creatorNascimento Júnior, Expedito da Silva
dc.creatorCavalcante, Judney Cley
dc.creatorCosta, Miriam Stela Maris de Oliveira
dc.creatorPinato, Luciana
dc.creatorToledo, Claudio Antonio Barbosa de
dc.creatorCavalcante, Jeferson de Souza
dc.date2014-05-20T15:09:05Z
dc.date2016-10-25T17:43:37Z
dc.date2014-05-20T15:09:05Z
dc.date2016-10-25T17:43:37Z
dc.date2010-12-01
dc.date.accessioned2017-04-05T22:43:30Z
dc.date.available2017-04-05T22:43:30Z
dc.identifierPsychology & Neuroscience. Pontificia Universidade Católica do Rio de JaneiroUniversidade de Brasília (UnB)Universidade de São Paulo, v. 3, n. 2, p. 217-228, 2010.
dc.identifier1983-3288
dc.identifierhttp://hdl.handle.net/11449/27094
dc.identifierhttp://acervodigital.unesp.br/handle/11449/27094
dc.identifier10.3922/j.psns.2010.2.011
dc.identifierS1983-32882010000200011
dc.identifierS1983-32882010000200011.pdf
dc.identifierhttp://dx.doi.org/10.3922/j.psns.2010.2.011
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/871796
dc.descriptionAll mammal behaviors and functions exhibit synchronization with environmental rhythms. This is accomplished through an internal mechanism that generates and modulates biological rhythms. The circadian timing system, responsible for this process, is formed by connected neural structures. Pathways receive and transmit environmental cues to the central oscillator, the hypothalamic suprachiasmatic nucleus, which mediates physiological and behavioral alterations. The suprachiasmatic nucleus has three major inputs: the retinohypothalamic tract (a direct projection from the retina), the geniculohypothalamic tract (an indirect photic projection originating in the intergeniculate leaflet), and a dense serotonergic plexus from the raphe nuclei. The serotonergic pathway, a source of non-photic cues to the suprachiasmatic nucleus, modulates its activity. The importance of raphe nuclei in circadian rhythms, especially in photic responses, has been demonstrated in many studies. Serotonin is the raphe neurotransmitter that triggers phase shifts, inhibits light-induced phase-shifts, and plays a role in controlling the sleep-wake cycle. All data to date have demonstrated the importance of the raphe, through serotonergic afferents, in adjusting circadian rhythms and must therefore be considered a component of the circadian timing system. The aim of this paper is to review the literature addressing the involvement of serotonin in the modulation of circadian rhythm.
dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.descriptionConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.descriptionCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.languageeng
dc.publisherPontifícia Universidade Católica do Rio de Janeiro (PUC-Rio)
dc.publisherUniversidade de Brasília (UnB)
dc.publisherUniversidade de São Paulo (USP)
dc.relationPsychology & Neuroscience
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectraphe
dc.subjectcircadian timing system
dc.subjectserotonin
dc.subjectcircadian rhythm
dc.subjectsuprachiasmatic nucleus
dc.titleSerotonin and circadian rhythms
dc.typeOtro


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