End-systolic pressure-diameter relation of the left ventricle during transient and sustained elevations of blood pressure

dc.contributorUniversidade Estadual Paulista (UNESP)
dc.creatorBregagnollo, Edson Antônio
dc.creatorOkoshi, Katashi
dc.creatorMatsubara, Beatriz Bojikian
dc.creatorTucci, Paulo José Ferreira
dc.date2014-05-20T15:07:13Z
dc.date2016-10-25T17:42:01Z
dc.date2014-05-20T15:07:13Z
dc.date2016-10-25T17:42:01Z
dc.date2000-07-01
dc.date.accessioned2017-04-05T22:36:15Z
dc.date.available2017-04-05T22:36:15Z
dc.identifierArquivos Brasileiros de Cardiologia. Sociedade Brasileira de Cardiologia - SBC, v. 75, n. 1, p. 26-32, 2000.
dc.identifier0066-782X
dc.identifierhttp://hdl.handle.net/11449/26421
dc.identifierhttp://acervodigital.unesp.br/handle/11449/26421
dc.identifier10.1590/S0066-782X2000000700003
dc.identifierS0066-782X2000000700003
dc.identifierS0066-782X2000000700003.pdf
dc.identifier2-s2.0-0041494278
dc.identifierhttp://dx.doi.org/10.1590/S0066-782X2000000700003
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/871131
dc.descriptionOBJECTIVE: To assess the effect of transient and sustained variations in cardiac load on the values of the end-systolic pressure-diameter relation (ESPDR) of the left ventricle. METHODS: We studied 13 dogs under general anesthesia and autonomic blockade. Variations of cardiac loads were done by elevation of blood pressure by mechanical constriction of the aorta. Two protocols were used in each animal: gradual peaking and decreasing pressure variation, the transient arterial hypertension protocol (TAH), and a quick and 10 min sustained elevation, the sustained arterial hypertension protocol(SAH). Then, we compared the ESDR in these two situations. RESULTS: Acute elevation of arterial pressure, being it transitory or sustained, did not alter the heart frequency and increased similarly the preload and after load. However, they acted differently in end systolic pressure-diameter relation. It was greater in the SAH than TAH protocol, 21.0±7.3mmHg/mm vs. 9.2±1.2mmHg/mm (p<0.05). CONCLUSION: The left ventricular ESPDR values determined during sustained pressure elevations were higher than those found during transient pressure elevations. The time-dependent activation of myocardial contractility associated with the Frank-Starling mechanism is the major factor in inotropic stimulation during sustained elevations of blood pressure, determining an increase in the ESPDR values.
dc.languageeng
dc.publisherSociedade Brasileira de Cardiologia (SBC)
dc.relationArquivos Brasileiros de Cardiologia
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectend-systolic pressure-diameter relations
dc.subjectcardiac inotropism
dc.subjectarterial hypertension
dc.titleEnd-systolic pressure-diameter relation of the left ventricle during transient and sustained elevations of blood pressure
dc.typeOtro


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