Asociación entre niveles de zinc y trastorno depresivo mayor, Manizales período 2019-2020: estudio ZINDEPA

dc.contributorCastaño Ramírez, Oscar Mauricio
dc.contributorSalud mental y Comportamiento Humano (Categoría C)
dc.creatorGarcía Restrepo, María Natalia
dc.date2023-01-31T13:22:49Z
dc.date2023-01-31T13:22:49Z
dc.date2023-01-30
dc.date.accessioned2023-09-06T18:35:08Z
dc.date.available2023-09-06T18:35:08Z
dc.identifierhttps://repositorio.ucaldas.edu.co/handle/ucaldas/18759
dc.identifierUniversidad de Caldas
dc.identifierRepositorio Institucional Universidad de Caldas
dc.identifierhttps://repositorio.ucaldas.edu.co
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/8699604
dc.descriptionIlustraciones
dc.descriptionspa:Introducción y objetivos: La etiología del trastorno depresivo mayor se ha relacionado entre otros con déficits de microelementos como el zinc (Zn). El objetivo de este estudio es determinar la asociación entre los niveles séricos de Zn, la fuerza muscular y la depresión. Métodos: Estudio observacional, analítico de casos y controles con 103 pacientes hospitalizados en la Clínica San Juan de Dios en Manizales por trastorno depresivo mayor y 36 controles sin historia personal de enfermedad mental. Los grupos se parearon por sexo, edad, nivel educativo y estrato socioeconómico. La severidad de la depresión se evaluó mediante la escala Montgomery – Asberg (MADS). Se determinaron los niveles séricos de Zn y se evaluó la fuerza de prensión manual. Se realizaron análisis descriptivos, regresión logística binaria y regresión lineal, siendo la variable dependiente la severidad de la depresión. Resultados: Los niveles bajos de Zn y una menor fuerza muscular estuvieron relacionados con la presencia de depresión. Hubo asociación positiva entre la menor fuerza muscular y los puntajes altos en la escala MADS. Conclusión: Se encontró una asociación entre depresión y niveles bajos de Zn, y una asociación inversa entre la gravedad de la depresión y la fuerza muscular
dc.descriptioneng:Background and Objectives: The etiology of major depressive disorder has been related among others factors to deficiencies of microelements such as zinc (Zn). This study aimed to determine the association between serum Zn levels, muscle strength, and depression. Methods: An observational, analytical case-control study with 103 depressive patients hospitalized at the San Juan de Dios Clinic in Manizales, and 36 controls with no personal history of mental illness were evaluated for serum zinc levels (Zn),. The groups were matched by sex, age, educational level, and socioeconomic stratum. The severity of depression was assessed using the Montgomery – Asberg rating scale (MADRS). Serum Zn levels were determined and manual grip strength was assessed. Descriptive analysis, binary logistic regression and linear regression were performed with severity of depression as dependent variable. Results: Low Zn levels and reduced muscle strength were related to the presence of depression. There was a positive association between lower muscle strength and higher scores on the MADRS scale. Conclusion: An association was found between depression and low Zn levels, and an inverse association between severity of depression and muscle strength.
dc.descriptionContenido / Introducción / 1. Planteamiento del problema y justificación / 2. Marco teórico / Trastorno depresivo mayor: / Instrumentos para la determinación de la gravedad de la depresión mayor: / Epidemiología del trastorno depresivo mayor / Factores de riesgo para depresión mayor / Fisiopatología de la depresión / Tratamiento de la depresión / Depresión resistente: / Pronóstico / Fuerza muscular: / Métodos de medición de la fuerza muscular: / El zinc (Zn): / Absorción: / Funciones y equilibrio: / Excreción de zinc / El zinc y el músculo : / El zinc y el cerebro: / Fuentes nutricionales del zinc: / Deficiencia de zinc / 3. Objetivo general / 4. Objetivos específicos / 5. Estrategia metodológica / Hipótesis del investigador / Población y muestra / Procedimiento: / Cuadro de operacionalización de variables / Análisis estadístico / Cronograma / Componente bioético / Compromiso social / Compromiso medioambiental / Difusión de resultados / 6. Resultados: / Características clínicas / 7. Discusión 8. Conclusiónes / 9. Referencias bibliográficas / 10. Anexos / 10.1 consentimiento informado
dc.descriptionEspecialización médico - quirúrgica
dc.descriptionEspecialista en Psiquiatría
dc.descriptionSalud Mental en el departamento de Caldas
dc.formatapplication/pdf
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dc.languageeng
dc.languagespa
dc.publisherFacultad de Ciencias para la Salud
dc.publisherManizales
dc.publisherEspecialización en Psiquiatría
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dc.rightsinfo:eu-repo/semantics/openAccess
dc.rightsinfo:eu-repo/semantics/openAccess
dc.rightsinfo:eu-repo/semantics/openAccess
dc.rightsinfo:eu-repo/semantics/openAccess
dc.rightshttp://purl.org/coar/access_right/c_abf2
dc.subjectTrastorno depresivo mayor
dc.subjectZinc
dc.subjectFuerza muscular
dc.subjectNutrición
dc.subjectSalud mental
dc.titleAsociación entre niveles de zinc y trastorno depresivo mayor, Manizales período 2019-2020: estudio ZINDEPA
dc.typeTrabajo de grado - Especialización
dc.typehttp://purl.org/coar/resource_type/c_bdcc
dc.typeText
dc.typeinfo:eu-repo/semantics/masterThesis
dc.typeinfo:eu-repo/semantics/publishedVersion


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