Hypothyroidism in postmenopausal women, prevalence in the Coffee Region, Colombia, 2016–2019

Hipotiroidismo en mujeres en la posmenopausia, prevalencia en el Eje Cafetero, Colombia, 2016-2019;
Hipotiroidismo em mulheres na pós-menopausa, prevalência no Eje Cafetero, Colômbia, 2016-2019

dc.creatorEspitia De La Hoz, Franklin José
dc.date2021-06-04
dc.date2023-03-22T19:09:45Z
dc.date2023-03-22T19:09:45Z
dc.date.accessioned2023-09-06T17:53:06Z
dc.date.available2023-09-06T17:53:06Z
dc.identifierhttps://revistas.unimilitar.edu.co/index.php/rmed/article/view/4868
dc.identifier10.18359/rmed.4868
dc.identifierhttp://hdl.handle.net/10654/43512
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/8693287
dc.descriptionThe aim is to determine the prevalence of hypothyroidism in postmenopausal women in the Coffee Region. Materials and methods: cross-sectional study in 469 participants. Postmenopausal women over 40 years of age who sought outpatient care due to gynecological pathologies between July 2016 and June 2019 in three private university clinics in the Coffee Region, Colombia, were admitted. Women with a previous diagnosis of hypothyroidism or who refused to participate were excluded. Simple random sampling. Measured variables: sociodemographic, clinical, and surgical. Descriptive statistics were applied. Results: she mean age was 56.47 ± 7.14 years. The mean tsh values in the global population were 3.71 ± 1.94 μIU/mL, increasing with age. The prevalence of hypothyroidism in postmenopausal women was 48.61 % (n = 228/469) (95 % CI: 37.83–54.15) in the Coffee Region, being higher in obese women (54.41 %; 95 % CI, 43.29–49.41 %) and those over 60 (52.35 %; 95 % CI: 20.64–31.77). Anti-thyroid peroxidase antibodies (TPOAB) were detected in 46.05 % (n = 105/228) and thyroglobulin antibodies (TgAB) in 21.05 % (n = 4 8/228) of hypothyroid women, showing an autoimmune phenomenon in 3.26 % (n = 153/469) o f the total population studied. Overweight, older age and antithyroid antibodies increase the prevalence of hypothyroidism (p < 0.05). Conclusions: 48.61 % of postmenopausal women from the Coffee Region have hypothyroidism.
dc.descriptionEl objetivo es determinar la prevalencia de hipotiroidismo en mujeres en la posmenopausia, en el Eje Cafetero. Materiales y métodos: estudio de corte transversal en 469 participantes. Se ingresaron mujeres mayores de 40 años, en la posmenopausia, que asistieron a la consulta externa para atención por patología ginecológica; entre julio de 2016 y junio de 2019, en tres clínicas privadas de carácter universitario, en el Eje Cafetero, Colombia. Se excluyeron mujeres con diagnóstico previo de hipotiroidismo o que se negaron a participar. Muestreo aleatorio simple. Variables medidas: sociodemográficas, clínicas y quirúrgicas. Se aplicó estadística descriptiva. Resultados: la edad media fue de 56,47 ± 7,14 años. La media de los valores de la tsh en la población global fue de 3,71 ± 1,94 μUI/mL, con tendencia al incremento a medida del aumento de la edad. La prevalencia de hipotiroidismo en mujeres en la posmenopausia fue del 48,61 % (n = 228/469) (IC95 %: 37,83-54,15), en el Eje Cafetero; siendo más elevada en las obesas (54,41 %; IC95 %, 43,29-49,41 %) y en las mayores de 60 (52,35 %; IC95 %: 20,64-31,77). Se detectaron anticuerpos antitiroideos antiperoxidasa (AC-TPO) en el 46,05 % (n = 105/228) y los antitiroglobulina (TgAb) en el 21,05 % (n = 48/228) de las mujeres hipotiroideas, evidenciándose un fenómeno autoinmune en el 3,26 % (n = 153/469) de la población total estudiada. El sobrepeso, el incremento de la edad y la presencia de anticuerpos antitiroideos aumentan significativamente la prevalencia de hipotiroidismo (p < 0,05). Conclusiones: el 48,61 % de las mujeres del Eje Cafetero en la posmenopausia presentan hipotiroidismo.
dc.descriptionO objetivo é determinar a prevalência de hipotiroidismo em mulheres na pós-menopausa, no Eje Cafetero (Eixo Cafeeiro). Materiais e métodos: estudo de corte transversal em 469 participantes. Foram incluídas mulheres maiores de 40 anos, na pós-menopausa, que foram à consulta externa para o atendimento por patologia ginecológica; entre julho de 2016 e junho de 2019, em três hospitais particulares de caráter universitário, no Eje Cafetero, Colômbia. Foram excluídas mulheres com diagnóstico prévio de hipotiroidismo ou que negaram a participar. Amostragem aleatória simples. Variáveis medidas: sociodemográficas, clínicas e cirúrgicas. Foi aplicada estatística descritiva. Resultados: a idade média foi de 56,47 ± 7,14 anos. A média dos valores da tsh na população global foi de 3,71 ± 1,94 μUI/mL, com tendência à elevação à medida que a idade aumentasse. A prevalência de hipotiroidismo em mulheres na pós-menopausa foi de 48,61 % (n = 228/469) (IC9 5%: 37,83-54,15), no Eje Cafetero; sendo mais elevada nas obesas (54,41 %; IC95 %, 43,29-49,41 %) e nas maiores de 60 (52,35 %; IC95 %: 20,64-31,77). Foram detectados anticorpos antitiroideus antiperoxidase (AC-TPO) em 46,05 % (n = 105/228) e os antitiroglobulina (TgAB) em 21,05 % (n = 48/228) das mulheres com hipotiroidismo, evidenciando-se um fenômeno autoimune em 3,26 % (n = 153/469) da população total estudada. O sobrepeso, o aumento da idade e a presença de anticorpos antitiroideus aumentam significativamente a prevalência de hipotiroidismo (p < 0,05). Conclusões: 48,61 % das mulheres do Eje Cafetero na pós-menopausa apresentam hipotiroidismo.
dc.formatapplication/pdf
dc.formattext/xml
dc.languagespa
dc.publisherUniversidad Militar Nueva Granada
dc.relationhttps://revistas.unimilitar.edu.co/index.php/rmed/article/view/4868/4628
dc.relationhttps://revistas.unimilitar.edu.co/index.php/rmed/article/view/4868/4784
dc.relation/*ref*/Jonklaas J, Bianco AC, Bauer AJ, Burman KD, Cappola AR, Celi FS, et al. Guidelines for the treatment of hypothyroidism: prepared by the American Thyroid Association task force on thyroid hormone replacement. Thyroid. 2014;24(12):1670-1751. https://doi.org/10.1089/thy.2014.0028
dc.relation/*ref*/Chaker L, Bianco AC, Jonklaas J, Peeters RP. Hypothyroidism. The Lancet. 2017;390(10101):1550-1562. https://doi.org/10.1016/S0140-6736(17)30703-1
dc.relation/*ref*/Garber JR, Cobin RH, Gharib H, Hennessey JV, Klein I, Mechanick JI, et al. Clinical practice guidelines for hypothyroidism in adults: cosponsored by the American Association of Clinical Endocrinologists and the American Thyroid Association. Endocr Pract. 2012;18(6):988-1028. https://doi.org/10.4158/EP12280.GL
dc.relation/*ref*/Pearce SH, Brabant G, Duntas LH, Monzani F, Peeters RP, Razvi S, et al. 2013 ETA guideline: management of subclinical hypothyroidism. Eur Thyroid J. 2013;2(4):215-28. https://doi.org/10.1159/000356507
dc.relation/*ref*/Vanderpump MP. The epidemiology of thyroid disease. Br Med Bull. 2011;99(1):39-51. https://doi.org/10.1093/bmb/ldr030
dc.relation/*ref*/Parle JV, Franklyn JA, Cross KW, Jones SC, Sheppard MC. Prevalence and follow-up of abnormal thyrotrophin (TSH) concentrations in the elderly in the United Kingdom. Clin Endocrinol (Oxf). 1991;34(1):77-84. https://doi.org/10.1111/j.1365-2265.1991.tb01739.x
dc.relation/*ref*/Gussekloo J, van Exel E, de Craen AJ, Meinders AE, Frölich M, Westendorp RG. Thyroid status, disability and cognitive function, and survival in old age. JAMA. 2004;292(21):2591-2599. https://doi.org/10.1001/jama.292.21.2591
dc.relation/*ref*/Almandoz JP, Gharib H. Hypothyroidism: etiology, diagnosis, and management. Med Clin North Am. 2012;96(2):203-221. https://doi.org/10.1016/j.mcna.2012.01.005
dc.relation/*ref*/Baumgartner C, Blum MR, Rodondi N. Subclinical hypothyroidism: summary of evidence in 2014. Swiss Med Wkly. 2014;(144):w14058. https://doi.org/10.4414/smw.2014.14058
dc.relation/*ref*/Vanderpump MP, Tunbridge WM, French JM, Appleton D, Bates D, Clark F, et al. The incidence of thyroid disorders in the community: a twenty-year follow-up of the Whickham Survey. Clin Endocrinol (Oxf). 1995; 43(1):55-68. https://doi.org/10.1111/j.1365-2265.1995.tb01894.x
dc.relation/*ref*/Duntas LH. Thyroid disease and lipids. Thyroid. 2002;12(4):287-93. https://doi.org/10.1089/10507250252949405
dc.relation/*ref*/Friis T, Pedersen LR. Serum lipids in hyper- and hypothyroidism before and after treatment. Clin Chim Acta. 1987;162(2):155-63. https://doi.org/10.1016/0009-8981(87)90447-5
dc.relation/*ref*/Canaris GJ, Manowitz NR, Mayor G, Ridgway EC. The Colorado thyroid disease prevalence study. Arch Intern Med. 2000;160(4):526-34. https://doi.org/10.1001/archinte.160.4.526
dc.relation/*ref*/Raterman HG, van Eijk IC, Voskuyl AE, Peters MJ, Dijkmans BA, van Halm VP, et al. The metabolic syndrome is amplified in hypothyroid rheumatoid arthritis patients: a cross-sectional study. Ann Rheum Dis. 2010;69(1):39-42. https://doi.org/10.1136/ard.2008.100776
dc.relation/*ref*/Jung CH, Sung KC, Shin HS, Rhee EJ, Lee WY, Kim BS, et al. Thyroid dysfunction and their relation to cardiovascular risk factors such as lipid profile, hsCRP, and waist hip ratio in Korea. Korean J Intern Med. 2003;18(3):146-153. https://doi.org/10.3904/kjim.2003.18.3.146
dc.relation/*ref*/Lambadiari V, Boutati E, Nikzas D, Tountas N, Economopoulos T, Raptis SA, et al. Studies of insulin resistance in patients with clinical and subclinical hypothyroidism. Eur J Endocrinol. 2009;160(5):785-790. https://doi.org/10.1530/EJE-08-0797
dc.relation/*ref*/Shepherd PR, Kahn BB. Glucose transporters and insulin action-implications for insulin resistance and diabetes mellitus. N Engl J Med. 1999;341(4):248-257. https://doi.org/10.1056/NEJM199907223410406
dc.relation/*ref*/Surks MI, Ortiz E, Daniels GH, Sawin CT, Col NF, Cobin RH, et al. Subclinical thyroid disease: scientific review and guidelines for diagnosis and management. JAMA. 2004; 291(2):228-238. https://doi.org/10.1001/jama.291.2.228
dc.relation/*ref*/Demers LM, Spencer CA. Laboratory medicine practice guidelines: laboratory support for the diagnosis and monitoring of thyroid disease. Clin Endocrinol (Oxf). 2003;58(2):138-140. https://doi.org/10.1046/j.1365-2265.2003.01681.x
dc.relation/*ref*/Guevara-Sánchez O, Holst-Schumacher I, Boza-Oreamuno S, Barrantes-Santamaría M, Chinchilla-Monge R, Alvarado-Ulate P. Disfunción tiroidea subclínica en población adulta costarricense. An Fac Med. 2015;76(4):333-338. https://doi.org/10.15381/anales.v76i4.11402
dc.relation/*ref*/Fardella C. Epidemiología de los trastornos tiroideos [Revista en linea]. Santiago de Chile. 2000;29(3).
dc.relation/*ref*/Londoño ÁL, Gallego ML, Bayona A, Landázuri P. Prevalencia de hipotiroidismo y relación con niveles elevados de anticuerpos antiperoxidasa y yoduria en población de 35 y más años en Armenia. 2009-2010. Rev salud pública. 2011;13(6):998-1009. https://doi.org/10.1590/S0124-00642011000600012
dc.relation/*ref*/Espitia-De La Hoz FJ, Orozco-Santiago L. Prevalencia y caracterización clínica del hipotiroidismo, en gestantes del Eje Cafetero (Colombia), 2014-2017. Revista Colombiana de Endocrinología, Diabetes & Metabolismo. 2019;6(4):260-267. Disponible en: http://revistaendocrino.org/index.php/rcedm/article/view/543/708
dc.relation/*ref*/Hinojosa-Rodríguez KA, Martínez-Cruz N, Ortega-González C, López-Rioja MJ, Recio-López Y, Sánchez-González CM. Prevalencia de autoinmunidad tiroidea en mujeres subfértiles. Ginecol Obstet Mex. 2017;85(10):694-704. https://doi.org/10.24245/gom.v85i10.1577
dc.relation/*ref*/Rugge JB, Bougatsos C, Chou R. Screening and treatment of thyroid dysfunction: an evidence review for the U.S. Preventive Services Task Force. Ann Intern Med. 2015;162(1):35-45. https://doi.org/10.7326/M14-1456
dc.relation/*ref*/Rallison ML, Dobyns BM, Meikle AW, Bishop M, Lyon JL, Stevens W. Natural history of thyroid abnormalities: prevalence, incidence, and regression of thyroid diseases in adolescents and young adults. Am J Med. 1991;91(4):363-370. https://doi.org/10.1016/0002-9343(91)90153-O
dc.relation/*ref*/Tunbridge WM, Evered DC, Hall R, Appleton D, Brewis M, Clark F, et al. The spectrum of thyroid disease in a community: the Whickham survey. Clin Endocrinol (Oxf). 1977;7(6):481-493. https://doi.org/10.1111/j.1365-2265.1977.tb01340.x
dc.relation/*ref*/Sichieri R, Baima J, Marante T, de Vasconcellos MT, Moura AS, Vaisman M. Low prevalence of hypothyroidism among black and Mulatto people in a population-based study of Brazilian women. Clin Endocrinol (Oxf). 2007;66(6):803-807. https://doi.org/10.1111/j.1365-2265.2007.02816.x
dc.relation/*ref*/Hollowell JG, Staehling NW, Flanders WD, Hannon WH, Gunter EW, Spencer CA, et al. Serum TSH, T(4), and thyroid antibodies in the United States population (1988 to 1994): National Health and Nutrition Examination Survey (NHANES III). J Clin Endocrinol Metab. 2002;87(2):489-499. https://doi.org/10.1210/jcem.87.2.8182
dc.relation/*ref*/Effraimidis G, Strieder TG, Tijssen JG, Wiersinga WM. Natural history of the transition from euthyroidism to overt autoimmune hypo- or hyperthyroidism: a prospective study. Eur J Endocrinol. 2011;164(1):107-113. https://doi.org/10.1530/EJE-10-0785
dc.relation/*ref*/Walsh JP, Bremner AP, Feddema P, Leedman PJ, Brown SJ, O'Leary P. Thyrotropin and thyroid antibodies as predictors of hypothyroidism: a 13-year, longitudinal study of a community-based cohort using current immunoassay techniques. J Clin Endocrinol Metab. 2010;95(3):1095-1104. https://doi.org/10.1210/jc.2009-1977
dc.relation/*ref*/Acharya N, Acharya S, Shukla S, Inamdar SA, Khatri M, Mahajan SN. Gonadotropin levels in hypothyroid women of reproductive age group. J Obstet Gynaecol India. 2011;61(5):550-553. https://doi.org/10.1007/s13224-011-0079-7
dc.relation/*ref*/Manish C, Ranjeet K, Gurinder M, Rahul M. Prevalence of hypothyroidism in adults by screening TSH: a study from North India. Int J Adv Med. 2016;3(1):44-46. https://doi.org/10.18203/2349-3933.ijam20160186
dc.relation/*ref*/Papaleontiou M, Haymart MR. Approach to and treatment of thyroid disorders in the elderly. Med Clin North Am. 2012;96(2):297-310. https://doi.org/10.1016/j.mcna.2012.01.013
dc.relation/*ref*/LeFevre ML; U.S. Preventive Services Task Force. Screening for thyroid dysfunction: U.S. Preventive Services Task Force recommendation statement. Ann Intern Med. 2015;162(9):641-650. https://doi.org/10.7326/M15-0483
dc.relation/*ref*/Yeh HC, Futterweit W, Gilbert P. Micronodulation: ultrasonographic sign of Hashimoto thyroiditis. J Ultrasound Med. 1996;15(12):813-819. https://doi.org/10.7863/jum.1996.15.12.813
dc.relation/*ref*/Deshmukh V, Behl A, Iyer V, Joshi H, Dholye JP, Varthakavi PK. Prevalence, clinical and biochemical profile of subclinical hypothyroidism in normal population in Mumbai. Indian J Endocrinol Metab. 2013;17(3):454-459. https://doi.org/10.4103/2230-8210.111641
dc.relation/*ref*/Bastenie PA. Hypothyroidism and Coronary heart disease. Acta Cardiol 1982;37(5):365-373.
dc.relation/*ref*/Biondi B, Warftosky L. Treatment with thyroid hormone. Endocr Rev. 2014;35(3):433-512. https://doi.org/10.1210/er.2013-1083
dc.relation/*ref*/Fox CS, Pencina MJ, D'Agostino RB, Murabito JM, Seely EW, Pearce EN, et al. Relations of thyroid function to body weight: cross-sectional and longitudinal observations in a community-based sample. Arch Intern Med. 2008;168(6):587-592. https://doi.org/10.1001/archinte.168.6.587
dc.relation/*ref*/Gopinath B, Liew G, Flood VM, Wang JJ, Kifley A, Leeder SR, et al. The association between weight gain and thyroid function in an older population. Arch Intern Med. 2008;168(20):2283-2284. https://doi.org/10.1001/archinte.168.20.2283
dc.relation/*ref*/Knudsen N, Laurberg P, Rasmussen LB, Bülow I, Perrild H, Ovesen L, et al. Small differences in thyroid function may be important for body mass index and the occurrence of obesity in the population. J Clin Endocrinol Metab. 2005;90(7):4019-4024. https://doi.org/10.1210/jc.2004-2225
dc.relation/*ref*/Ortega E, Pannacciulli N, Bogardus C, Krakoff J. Plasma concentrations of free triiodothyronine predict weight change in euthyroid persons. Am J Clin Nutr. 2007;85(2):440-445. https://doi.org/10.1093/ajcn/85.2.440
dc.rightsDerechos de autor 2021 Revista Med
dc.sourceRevista Med; Vol. 28 No. 2 (2020): july - december; 61-70
dc.sourceRevista Med; Vol. 28 Núm. 2 (2020): julio - diciembre; 61-70
dc.source1909-7700
dc.source0121-5256
dc.titleHypothyroidism in postmenopausal women, prevalence in the Coffee Region, Colombia, 2016–2019
dc.titleHipotiroidismo en mujeres en la posmenopausia, prevalencia en el Eje Cafetero, Colombia, 2016-2019
dc.titleHipotiroidismo em mulheres na pós-menopausa, prevalência no Eje Cafetero, Colômbia, 2016-2019
dc.typeinfo:eu-repo/semantics/article
dc.typeinfo:eu-repo/semantics/publishedVersion


Este ítem pertenece a la siguiente institución