Bioethics and research: case study analysis. of Ebola virus epidemic in 2014

Bioética e investigación: análisis de caso de la epidemia por el virus del ébola en 2014;
Bioética e investigação: análise de caso epidemia. do vírus ebola em 2014

dc.creatorPinto, Boris Julian
dc.creatorGómez Córdoba, Ana Isabel
dc.creatorWintaco, Luz Maira
dc.creatorAmador, Diana Patricia
dc.creatorGonzález, Germán Andrés
dc.creatorCarabalí, Mary Lilián
dc.creatorArarat Sarria, Mónica
dc.creatorOlaya, Nury Natalia
dc.creatorPatiño, Luz Helena
dc.creatorSanabria, Alfredo José
dc.date2016-11-16
dc.date2023-03-22T19:06:05Z
dc.date2023-03-22T19:06:05Z
dc.date.accessioned2023-09-06T17:43:39Z
dc.date.available2023-09-06T17:43:39Z
dc.identifierhttps://revistas.unimilitar.edu.co/index.php/rlbi/article/view/1943
dc.identifier10.18359/rlbi.1943
dc.identifierhttp://hdl.handle.net/10654/43348
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/8692467
dc.descriptionThe Ebola virus epidemic in West Africa (2014) has raised some ethical questions surrounding public health measures for its containment, the use of experimental drugs and the development of vaccines against this disea- se. This paper explores some of these issues from the perspective of ethics in biomedical research. Ebola virus epidemic is a suitable study model to address multilateral efforts in research as well as to analyze anthropological aspects of public health and social, economic and political determinants of global health.
dc.descriptionLa epidemia por el virus Ébola en África occidental (2014) ha suscitado una serie de interrogantes éticos en torno a las medidas de salud pública para su contención, el uso de medicamentos experimentales y el desarrollo de vacunas contra esta enfermedad. El presente trabajo explora algunas de estas preguntas desde la perspectiva de la ética en investigación biomédica. La epidemia por el virus Ébola es un modelo de estudio adecuado para abordar esfuerzos multilaterales en investigación, así como para analizar aspectos antropológicos en salud pública y determinantes sociales, económicos y políticos en salud a nivel global.
dc.descriptionA epidemia pelo vírus Ebola, na África Ocidental (2014), tem levantado uma série de questões éticas em torno às medidas de saúde pública para a sua contenção, o uso de medicamentos experimentais e o desenvolvimento de vacinas contra esta doença. Este artigo explora algumas destas questões a partir da perspectiva da  tica na pesquisa biomédica. A epidemia pelo vírus Ebola é um modelo de estudo adequado para abordar esforços multilaterais em pesquisa, como também para analisar aspectos antropológicos em saúde pública e determinantes sociais, econômicos e políticos em saúde a nível global.
dc.formatapplication/pdf
dc.formattext/html
dc.formatapplication/msword
dc.formatapplication/pdf
dc.formatapplication/pdf
dc.formatapplication/pdf
dc.formatapplication/pdf
dc.formatapplication/pdf
dc.formatapplication/pdf
dc.formatapplication/pdf
dc.formatapplication/pdf
dc.languagespa
dc.publisherUniversidad Militar Nueva Granada
dc.relationhttps://revistas.unimilitar.edu.co/index.php/rlbi/article/view/1943/2156
dc.relationhttps://revistas.unimilitar.edu.co/index.php/rlbi/article/view/1943/2570
dc.relationhttps://revistas.unimilitar.edu.co/index.php/rlbi/article/view/1943/3104
dc.relationhttps://revistas.unimilitar.edu.co/index.php/rlbi/article/view/1943/3105
dc.relationhttps://revistas.unimilitar.edu.co/index.php/rlbi/article/view/1943/3106
dc.relationhttps://revistas.unimilitar.edu.co/index.php/rlbi/article/view/1943/3107
dc.relationhttps://revistas.unimilitar.edu.co/index.php/rlbi/article/view/1943/3108
dc.relationhttps://revistas.unimilitar.edu.co/index.php/rlbi/article/view/1943/3109
dc.relationhttps://revistas.unimilitar.edu.co/index.php/rlbi/article/view/1943/3110
dc.relationhttps://revistas.unimilitar.edu.co/index.php/rlbi/article/view/1943/3111
dc.relationhttps://revistas.unimilitar.edu.co/index.php/rlbi/article/view/1943/3112
dc.relation/*ref*/Adebamowo, C., Bah-Sow, O., Binka, F., Bruzzone, R. et al. (2014). Randomised controlled trials for Ebola: practical and ethical issues. The Lancet, 384(9952), 1423-4. https://doi.org/10.1016/S0140-6736(14)61734-7
dc.relation/*ref*/Asociación Médica Mundial [AMM]. (2013). Declaración Helsinki, Principios éticos para las investigaciones médicas en seres humanos. 64ª Asamblea General. Fortaleza, Brasil.
dc.relation/*ref*/Bausch, D.G., Sprecher, A.G., Jeffs, B., Boumandouki, P. (2008). Treatment of Marburg and Ebola hemorrhagic fevers: a strategy for testing new drugs and vaccines under outbreak conditions. Antiviral Research, 78(1), 150-161. https://doi.org/10.1016/j.antiviral.2008.01.152
dc.relation/*ref*/Benatar, S. (2015). Explaining and responding to the Ebola epidemic. Philosophy, Ethics, and Humanities in Medicine, 10(5), 1-3. https://doi.org/10.1186/s13010-015-0027-8
dc.relation/*ref*/Bogoch, I.I., Creatore, M.I., Cetron, M.S., Brownstein, J.S. et al. (2015). Assessment of the potential for international dissemination of Ebola virus via commercial air travel during the 2014 west African outbreak. Lancet, 3(9962), 29-35. https://doi.org/10.1016/S0140-6736(14)61828-6
dc.relation/*ref*/Boozary, A.S., Farmer, P.E. y Jha, A.K. (2014). The Ebola Outbreak, Fragile Health Systems, and Quality as a Cure. Journal of the American Medical Association, 312(18), 1859-1860. https://doi.org/10.1001/jama.2014.14387
dc.relation/*ref*/Caplan, A.L., Plunkett, C. y Levin, B. (2015). Selecting the right tool for the job. The American Journal of Bioethics, 15(4), 4-10. https://doi.org/10.1080/15265161.2015.1010993
dc.relation/*ref*/Centers for Disease Control and Prevention [CDC] (2015a). Ebola (Ebola Virus Disease). Recuperado el 12 de noviembre de 2015, de http://www.cdc.gov/vhf/Ebola/transmission/index.html
dc.relation/*ref*/Centers for Disease Control and Prevention [CDC] (2015b). Enfermedad del virus del Ebola. Prevención. Recuperado el 18 de noviembre de 2015, de http://espanol.cdc.gov/vhf/ebola/prevention/index.html
dc.relation/*ref*/Check, E. (2015). Proposed Ebola biobank would strengthen African science. Nature, 524(7564), 146-147. https://doi.org/10.1038/524146a
dc.relation/*ref*/Coffey, C.S., Levin, B., Clark. C., Timmerman, C. et al. (2012). Overview, hurdles, and future work in adaptive designs: Perspectives from an NIH funded workshop. Clinical Trials, 9(6), 671-680. https://doi.org/10.1177/1740774512461859
dc.relation/*ref*/Cohen, J. y Kupferschmidt, K. (2014). Ebola vaccine trials raise ethical issues: Randomized studies may offer fastest answer. Science Magazine, 346(6207), 289-290. https://doi.org/10.1126/science.346.6207.289
dc.relation/*ref*/Council for International Organizations of Medical Sciences [CIOMS] y World Health Organization [WHO] (2002). Pautas éticas internacionales para la investigación y experimentación biomédica en seres humanos de la Organización Mundial de la Salud. Ginebra, pauta número 12. Recuperado el 21 de marzo de 2016, de http://www.cioms.ch/publications/guidelines/pautas_eticas_internacionales.htm
dc.relation/*ref*/Cox, E., Borio, L. y Temple R. (2014). Evaluating Ebola therapies. The case for RCTs. New England Journal of Medicine, 371(25), 2350-2351. https://doi.org/10.1056/NEJMp1414145
dc.relation/*ref*/Deaton, A. (2015). El gran escape. Salud, riqueza y el origen de la desigualdad. Madrid: Fondo de Cultura Económica.
dc.relation/*ref*/Donovan, G.K. (2014). Ebola, epidemics, and ethics. What we have learned? Philosophy, Ethics and Humanities in Medicine, 9(15), 2-4. https://doi.org/10.1186/1747-5341-9-15
dc.relation/*ref*/Emanuel, E. (1999). ¿Qué hace que la investigación clínica sea ética? Siete requisitos éticos. En A. Pellegrini Filho y R. Macklin (Eds.), Investigación en sujetos humanos: experiencia internacional (pp. 33-46). Santiago: Organización Panamericana de la Salud.
dc.relation/*ref*/Emanuel, E.J., Wendler, D. y Grady, C. (2008). An Ethical Framework for Biomedical Research. En J. Emanuel, C. Grady, R. Crouch, R. y F. Lie (Eds.), The Oxford textbook of clinical research ethics. Oxford: Oxford University Press.
dc.relation/*ref*/Farmer, P.E. (2014). Diary. London Review of Books, 36(20), 38-39. Recuperado el 18 de diciembre de 2015, de http://www.lrb.co.uk/v36/n20/paul-farmer/diary
dc.relation/*ref*/Feldmann, H., Klenk, H.D. y Sanchez, A. (1993). Molecular biology and evolution of filoviruses. Archives Virology, 7, 81-100. https://doi.org/10.1007/978-3-7091-9300-6_8
dc.relation/*ref*/Frieden, T.R., Damon, I., Bell, B.P., Kenyon, T. y Nichol, S. (2014). Ebola 2014. New Challenges, New Global Response and Responsibility. New England Journal of Medicine, 371, 1177-1180. https://doi.org/10.1056/NEJMp1409903
dc.relation/*ref*/Folayan, M.O. y Haire, B. (2015). Ethical considerations in the conduct of research on therapies for the prevention and treatment of Ebola virus disease in developing countries. Pan African Medical Journal, 22(Suppl 1), 8.
dc.relation/*ref*/Folayan, M.O, Peterson, K. y Kombe, F. (2015). Ethics, emergencies and Ebola clinical trials: the role of governments and communities in offshored research. Pan African Medical Journal, 22(Supp 1), 10.
dc.relation/*ref*/Folayan, M.O., Yakubu, A., Haire, B., Peterson, K. (2016). Ebola vaccine development plan: ethics, concerns and proposed measures. BMC Medical Ethics, 17(10). https://doi.org/10.1186/s12910-016-0094-4
dc.relation/*ref*/Gehring, G., Rohrmann, K., Atenchong, N. y Mittler, E. (2014). The clinically approved drugs amiodarone, dronedarone and verapamil inhibit filovirus cell entry. Journal of Antimicrobial Chemotherapy, 69(8), 2123-31. https://doi.org/10.1093/jac/dku091
dc.relation/*ref*/Gericke, C.A. (2015). Ebola and ethics: autopsy of a failure. BMJ, 350, h2105. https://doi.org/10.1136/bmj.h2105
dc.relation/*ref*/Gostin, L.O., Lucey, D. y Phelan, A. (2014). The Ebola Epidemic: A Global Health Emergency. JAMA, 312(11), 1095-1096. https://doi.org/10.1001/jama.2014.11176
dc.relation/*ref*/Griffiths, P.D. (2014). Ebola and ethics. Reviews in Medical Virology, 24(6), 363-364. https://doi.org/10.1002/rmv.1812
dc.relation/*ref*/Hayden, E.C. (2014). Ethical dilemma for Ebola drug trials. Nature, 515(7526), 177-178. https://doi.org/10.1038/515177a
dc.relation/*ref*/Instituto de Salud Global de Barcelona [ISGlobal]. (2016). Ébola: dos a-os y 11 300 muertes después. Recuperado el 17 de marzo de 2016, de http://www.isglobal.org/Ebola
dc.relation/*ref*/Jecker, N.S., Dudzinski, D.M., Diekema, D.S. y Tonelli, M. (2015). Ebola virus disease. Ethics and emergency medical response policy. Chest, 148(3), 794-800. https://doi.org/10.1378/chest.15-0135
dc.relation/*ref*/Joffe, S. (2014). Evaluating novel therapies during the Ebola Epidemic. JAMA, 312(13), 1299-1300. https://doi.org/10.1001/jama.2014.12867
dc.relation/*ref*/Kass, N. (2014). Ebola, Ethics, and Public Health: What Next? Annals of Internal Medicine, 161(10), 744-745. https://doi.org/10.7326/M14-1864
dc.relation/*ref*/Kilgore, P.E., Grabenstein, J.D., Salim, A.M., Rybak, M. (2015). Treatment of Ebola virus disease. Pharmacotherapy, 35(1), 43-53. https://doi.org/10.1002/phar.1545
dc.relation/*ref*/Komesaroff, P. y Kerridge. I. (2014). Ebola, Ethics, and the question of culture. Journal of Bioethical Inquiry, 11(4), 413-414. https://doi.org/10.1007/s11673-014-9581-9
dc.relation/*ref*/Kroll, D. (2014). Ebola 'Secret Serum': Small Biopharma, the army and Big Tobacco. Forbes-Pharma and Healthcare. Recuperado el 3 de marzo de 2016, de http://www.forbes.com/sites/davidkroll/2014/08/05/Ebola-secret-serum-small-biopharma-the-army-and-big-tobacco/
dc.relation/*ref*/Lazcano-Ponce, E., Salazar-Martínez, E., Gutiérrez-Castrellón, P., Angeles-Llerenas, A. et al. (2004). Ensayos clínicos aleatorizados: variantes, métodos de aleatorización, análisis, consideraciones éticas y regulación. Salud Pública de México, 46(6), 559-584. https://doi.org/10.1590/S0036-36342004000600012
dc.relation/*ref*/Lyon, G.M., Mehta, A.K., Varkey, J.B., Brantly, K., et al. (2014). Clinical Care of Two Patients with Ebola Virus Disease in the United States. New England Journal of Medicine, 371(25), 2402-2409. https://doi.org/10.1056/NEJMoa1409838
dc.relation/*ref*/Mackenzie, C., Rogers, W. y Dodds, S. (2014). Vulnerability. New Essays in Ethics and Feminist Philosophy. New York: Oxford University Press.
dc.relation/*ref*/Mapp Biopharmaceutical. (2014). ZMapp information sheet. Recuperado el 3 de marzo de 2016, de http://www.defyrus.com/images/ZMapp-information-sheet.pdf
dc.relation/*ref*/Marí Sáez, A., Kelly, A. y Brown, H. (2014). Apuntes sobre el paciente cero: antropología en los tiempos del Ébola. La marea.com. Recuperado el 21 de marzo de 2016, de http://www.lamarea.com/2014/10/09/apuntes-sobre-el-caso-paciente-cero-antropologia-en-los-tiempos-del-ebola/
dc.relation/*ref*/Marí Sáez, A., Weiss, S., Nowak, K, et al. (2015). Investigating the zoonotic origin of the West African Ebola epidemic. EMBO Molecular Medicine, 7, 17-23. https://doi.org/10.15252/emmm.201404792
dc.relation/*ref*/Mathers, C.D., Boerma, T. y Ma Fat, D. (2009). Global and regional causes of death. British Medical Bulletin, 92, 7-32. https://doi.org/10.1093/bmb/ldp028
dc.relation/*ref*/Mathers, C.D. y Loncar, D. (2006). Projections of Global Mortality and Burden of Disease from 2002 to 2030. PLoS Medicine, 3(11), e442. https://doi.org/10.1371/journal.pmed.0030442
dc.relation/*ref*/McCarthy, M. (2014). US signs contract with ZMapp maker to accelerate development of the Ebola drug. BMJ, 349, g5488. https://doi.org/10.1136/bmj.g5488
dc.relation/*ref*/Mehta, A.K., Varkey, J.B., Brantly, K., Pérez, C.E. y Faccini-Martínez, A.A. (2015). Epidemia de Ebola-201: enfocar los esfuerzos en el control desde su epicentro. Revista Panamericana de Infectología, 17(1), 5-6.
dc.relation/*ref*/Meltzer, L. y Childress, J. (2008). What is a fair participant selection? (capítulo 35) En E. J. Emanuel, C. Grady, R. Crouch et al. (Eds.), The Oxford textbook of clinical research ethics (pp. 377-383). Oxford: Oxford University Press.
dc.relation/*ref*/Mickleburgh, S., Waylen, K. y Racey, P. (2009). Bats as bushmeat: a global review. Oryx, 43, 217-234. https://doi.org/10.1017/S0030605308000938
dc.relation/*ref*/Morley, F. y Macleod, R. (2015). The Halifax Index 2015. An economic gut check with insights for action. (2015). Halifax partnership. Connect, collaborate, prosper. Recuperado el 21 de marzo de 2016, de http://www.halifaxpartnership.com/site/media/Parent/8x10_HalifaxIndex2015_June18_Web.pdf
dc.relation/*ref*/Murray, C.J.L., Rosenfeld, L.C., Lim, S.S., Andrews, K.G. et al. (2012). Global malaria mortality between 1980 and 2010: a systematic analysis. The Lancet, 379(9814), 413-431.https://doi.org/10.1016/S0140-6736(12)60034-8
dc.relation/*ref*/Nkoghé, D., Formenty, P., Nnégué, S., Toung Mvé, M. et al. (2004). Recommandations pratiques pour la prise en charge sur le terrain des patients infectés par le virus Ebola. Médecine Tropicale, 64(2), 199-204.
dc.relation/*ref*/Organización Mundial de la Salud [OMS] (2014a). Consideraciones éticas sobre el uso de intervenciones no registradas en la enfermedad por el virus del Ébola. Recuperado el 12 de octubre de 2015, de http://www.who.int/mediacentre/news/statements/2014/Ebola-ethical-review-summary/es/
dc.relation/*ref*/Organización Mundial de la Salud [OMS] (2014b). Statement on the WHO Consultation on potential Ebola therapies and vaccines. Recuperado el 21 de marzo de 2016, de http://www.who.int/mediacentre/news/statements/2014/Ebola-therapies-consultation/en/
dc.relation/*ref*/Organización Mundial de la Salud [OMS]. (2015a). Ebola Virus Disease. Recuperado el 26 de febrero de 2016, de http://www.who.int/mediacentre/factsheets/fs103/en/
dc.relation/*ref*/Organización Mundial de la Salud [OMS] (2015b). Ebola Situation Reports. Recuperado el 15 de diciembre de 2015, de http://apps.who.int/Ebola/Ebola-situation-reports
dc.relation/*ref*/Organización Mundial de la Salud [OMS] (2015c). Ebola data and satistics. Key indicators relevant to Ebola outbreak. Recuperado el 12 de noviembre de 2015, de http://apps.who.int/gho/data/node.Ebola.keyind?lang=en
dc.relation/*ref*/Pinto, B.J., Mojica, M.C., Gulfo, R., Endo, J.H., y Idárraga, J. (2014). Bioética y la brecha 10/90: fallos, desafíos y oportunidades. Revista Redbioética, 2(10), 81-93.
dc.relation/*ref*/Presidential Commission for the Study of Bioethical Issues. (2015). Ethics and Ebola Public Health Planning and Response. Recuperado el 16 de diciembre de 2015, de http://bioethics.gov/sites/default/files/Ethics-and-Ebola_PCSBI_508.pdf
dc.relation/*ref*/Programa Conjunto de las Naciones Unidas sobre el VIH/SIDA [ONUSIDA] (2015) Diapositivas clave sobre epidemiología, julio 2015. Recuperado el 19 de julio de 2015, de http://www.unaids.org/sites/default/files/media_asset/20150714_epi_core_es.pdf
dc.relation/*ref*/Pourrut, X., Kumulungui, B., Wittmann, T., Moussavou, G. et al. (2005). The natural history of Ebola virus in Africa. Microbes and Infection, 7(7-8), 1005-1014. https://doi.org/10.1016/j.micinf.2005.04.006
dc.relation/*ref*/Qiu, X., Wong, G., Audet, J., Bello, A. et al. (2014). Reversion of advanced Ebola virus disease in nonhuman primates with ZMapp. Nature, 514(7520), 47-53. https://doi.org/10.1038/nature13777
dc.relation/*ref*/Rid, A y Emanuel, E. (2014a). Why Should High-Income Countries Help Combat Ebola? JAMA, 312(13), 1297-1298. https://doi.org/10.1001/jama.2014.12869
dc.relation/*ref*/Rid, A. y Emanuel, E. (2014b). Ethical considerations of experimental interventions in the Ebola outbreak. The Lancet, 384(9957), 1896-1899. https://doi.org/10.1016/S0140-6736(14)61315-5
dc.relation/*ref*/Rid, A. y Miller, F. (2016). Ethical Rationale for the Ebola "Ring Vaccination" Trial Design. American Journal of Public Health, 106(3), 432-5. https://doi.org/10.2105/AJPH.2015.302996
dc.relation/*ref*/Roberts, I. y Perner, A. (2014). Ebola virus disease: clinical care and patient-centred research. The Lancet, 384, 2001-2002. https://doi.org/10.1016/S0140-6736(14)62316-3
dc.relation/*ref*/Shah, S., Wendler, D. y Danis, M. (2015). Examining the ethics of clinical use of unproven interventions outside of clinical trials during the Ebola epidemic. The American Journal of Bioethics, 15(4), 11-16. https://doi.org/10.1080/15265161.2015.1010996
dc.relation/*ref*/Shaul, R.Z., Langer, J.C., McKneally, M.F. (2008). Innovación en cuidados médicos: ejemplos de cirugía. En A. Singer Peter y A. Viens (Eds.), The Cambridge Textbook of Bioethics. New York: Cambridge University Press.
dc.relation/*ref*/Simonsen, S. (2012). Acceptable Risk in Biomedical Research. European Perspectives. Netherlands: Springer Science+Business Media. https://doi.org/10.1007/978-94-007-2678-9
dc.relation/*ref*/Smith, D.I.H. (1978). Ebola haemorrhagic fever in Sudan, 1976. Bulletin of the World Health Organization, 56(2), 247–270
dc.relation/*ref*/Taber, J. (2014). Hundreds of Nova Scotians volunteer for Ebola vaccine trial. The Globe and Mail. Recuperado el 21 de marzo de 2016, de http://www.theglobeandmail.com/life/health-and-fitness/health/hundreds-of-nova-scotians-volunteer-for-Ebola-vaccine-trial/article21712654
dc.relation/*ref*/United Nations Development Group [UNDG], Western and Central Africa. (2015). Socio-Economic Impact of Ebola Virus Disease in West African Countries. A call for national and regional containment, recovery and prevention. United Nations Development Group. Recuperado el 16 de noviembre de 2015, de https://undg.org/main/undg_document/socio-economic-impact-of-ebola-virus-disease-in-west-african-countries/
dc.relation/*ref*/Waldman, R. y Nieburg, P. (2015). Thoughts on Alternative Designs for Clinical Trials for Ebola Treatment Research. The American Journal of Bioethics, 15(4), 38-40. https://doi.org/10.1080/15265161.2015.1011001
dc.relation/*ref*/Yozwiak, N.L., Schaffner S.F. y Sabeti, P.C. (2015). Make outbreak research open access. Nature, 518, 477-479. https://doi.org/10.1038/518477a
dc.relation/*ref*/World Health Organization Ebola Response Team[WHO-ERT] (2014). Ebola Virus Disease in West Africa - the First 9 Months of the Epidemic and Forward Projections. New England Journal of Medicine, 371, 1481-1495.
dc.relation/*ref*/Zacharowski, K., Brodt, H.R. y Wolf, T. (2015). Medical treatment of an Ebola-infected doctor-ethics over costs? The Lancet, 385(9969), 685. https://doi.org/10.1016/S0140-6736(15)60279-3
dc.rightsDerechos de autor 2016 Revista Latinoamericana de Bioética
dc.sourceRevista Latinoamericana de Bioética; Vol. 17 Núm. 32-1 (2017): COMUNICACIÓN CIENTÍFICA Y REALIDAD SOCIAL; 124-149
dc.source2462-859X
dc.source1657-4702
dc.subjectBioethics
dc.subjectebola
dc.subjectresearch ethics
dc.subjectvaccines
dc.subjectvirus
dc.subjectEnfermedad por el virus de ébola
dc.subjectbioética
dc.subjectética en investigación
dc.subjectvacunas contra el ébola
dc.subjectDoença pelo vírus ebola
dc.subjectbioética
dc.subjectética em investigação
dc.subjectvacinas contra o ebola
dc.titleBioethics and research: case study analysis. of Ebola virus epidemic in 2014
dc.titleBioética e investigación: análisis de caso de la epidemia por el virus del ébola en 2014
dc.titleBioética e investigação: análise de caso epidemia. do vírus ebola em 2014
dc.typeinfo:eu-repo/semantics/article
dc.typeinfo:eu-repo/semantics/publishedVersion


Este ítem pertenece a la siguiente institución