C-terminal Motifs of HIV-1 gp41 as Possible Determinants of Viral Pathogenesis

Motivos C-terminales de gp41 del VIH-1 como posibles determinantes de la patogénesis viral;
Motivos C-terminais do HIV-1 gp41 como Possíveis Determinantes da Patogênese Viral

dc.creatorNarváez-Pardo, Jorge Andrés
dc.creatorVillarreal, José-Luis
dc.creatorVarela Prieto, Lourdes Luz
dc.creatorCervantes-Acosta, Guillermo
dc.date2022-08-01
dc.date2023-03-22T19:09:49Z
dc.date2023-03-22T19:09:49Z
dc.date.accessioned2023-09-06T17:38:27Z
dc.date.available2023-09-06T17:38:27Z
dc.identifierhttps://revistas.unimilitar.edu.co/index.php/rmed/article/view/5850
dc.identifier10.18359/rmed.5850
dc.identifierhttp://hdl.handle.net/10654/43537
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/8691927
dc.descriptionHuman immunodeficiency virus type 1 (HIV-1) is the etiological agent of acquired immunodeficiency syndrome (AIDS), a pandemic with high economic and social costs. The envelope glycoprotein (env) of the virus mediates the infectious process by binding to and entering the host cell, one of the main target components of studies since its discovery. Its endodomain or C-terminal tail (CTT) participates in late replicative cycle processes, such as intracellular trafficking, activation, and cell death, which occurs because it interacts with multiple cellular factors through motifs or signal sequences present throughout its structure. Although these interactions have not been fully understood at specific levels, studies over more than three decades leave no doubt that this domain plays a fundamental role in the biology of the virus and probably the development of the disease. This review describes the studies carried out to date that demonstrate the importance of the CTT, focusing on the motifs responsible for its interactions and its possible roles in the pathogenicity of the infection.
dc.descriptionEl virus de la inmunodeficiencia humana tipo 1 (VIH-1) es el agente etiológico del síndrome de inmunodeficiencia adquirida (SIDA), una pandemia con altos costos económicos y sociales. La glicoproteína de la envoltura (env) del virus media el proceso infeccioso al unirse a la célula huésped y entrar en ella, uno de los principales componentes objetivo de los estudios desde su descubrimiento. Su endodominio o cola C-terminal (CTT) participa en procesos tardíos del ciclo replicativo, como tráfico intracelular, activación y muerte celular, lo que ocurre porque interactúa con múltiples factores celulares a través de motivos o secuencias señal presentes en toda su estructura. Aunque estas interacciones no se han entendido completamente a niveles específicos, los estudios durante más de tres décadas no dejan dudas de que este campo juega un papel fundamental en la biología del virus y probablemente en el desarrollo de la enfermedad. Esta revisión describe los estudios realizados hasta la fecha que demuestran la importancia de la CTT, centrándose en los motivos responsables de sus interacciones y sus posibles roles en la patogenicidad de la infección.
dc.descriptionO vírus da imunodeficiência humana tipo 1 (HIV-1) é o agente etiológico da síndrome da imunodeficiência adquirida (AUXILIA), uma pandemia com elevados custos económicos e sociais. A glicoproteína do envelope (env) do vírus media o processo infeccioso ligando-se e entrando na célula hospedeira, um dos principais componentes alvo dos estudos desde sua descoberta. Seu endo domínio ou cauda C-terminal (CTT) participa de processos do ciclo replicativo tardio, como tráfego intracelular, ativação e morte celular, que ocorre porque interage com múltiplos fatores celulares por meio de motivos ou sequências-sinal presentes em toda a sua estrutura. Embora essas interações não tenham sido totalmente compreendidas em níveis específicos, estudos ao longo de mais de três décadas não deixam dúvidas de que esse domínio desempenha um papel fundamental na biologia do vírus e provavelmente no desenvolvimento da doença. Esta revisão descreve os estudos realiza- dos até o momento que demonstram a importância da CTT, com foco nos motivos responsáveis por suas interações e seus possíveis papéis na patogenicidade da infecção.
dc.formatapplication/pdf
dc.formattext/xml
dc.languageeng
dc.publisherUniversidad Militar Nueva Granada
dc.relationhttps://revistas.unimilitar.edu.co/index.php/rmed/article/view/5850/5208
dc.relationhttps://revistas.unimilitar.edu.co/index.php/rmed/article/view/5850/5292
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dc.rightsDerechos de autor 2023 Revista Med
dc.rightshttp://creativecommons.org/licenses/by-nc-nd/4.0
dc.sourceRevista Med; Vol. 29 No. 2 (2021): july - december; 107-120
dc.sourceRevista Med; Vol. 29 Núm. 2 (2021): julio - diciembre; 107-120
dc.source1909-7700
dc.source0121-5256
dc.titleC-terminal Motifs of HIV-1 gp41 as Possible Determinants of Viral Pathogenesis
dc.titleMotivos C-terminales de gp41 del VIH-1 como posibles determinantes de la patogénesis viral
dc.titleMotivos C-terminais do HIV-1 gp41 como Possíveis Determinantes da Patogênese Viral
dc.typeinfo:eu-repo/semantics/article
dc.typeinfo:eu-repo/semantics/publishedVersion


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