Antiestrogen therapies affect tissue homeostasis of the gerbil (Meriones unguiculatus) female prostate and ovaries

dc.contributorUniversidade Estadual Paulista (UNESP)
dc.creatorSantos, Fernanda C. A.
dc.creatorCustodio, Ana M. G.
dc.creatorCampos, Silvana G. P.
dc.creatorVilamaior, Patricia S. L.
dc.creatorGoes, Rejane M.
dc.creatorTaboga, Sebastiao R.
dc.date2014-05-20T14:00:52Z
dc.date2016-10-25T17:08:15Z
dc.date2014-05-20T14:00:52Z
dc.date2016-10-25T17:08:15Z
dc.date2008-10-01
dc.date.accessioned2017-04-05T21:24:03Z
dc.date.available2017-04-05T21:24:03Z
dc.identifierBiology of Reproduction. Madison: Soc Study Reproduction, v. 79, n. 4, p. 674-685, 2008.
dc.identifier0006-3363
dc.identifierhttp://hdl.handle.net/11449/21506
dc.identifierhttp://acervodigital.unesp.br/handle/11449/21506
dc.identifier10.1095/biolreprod.108.068759
dc.identifierWOS:000259305300012
dc.identifier0000-0002-0970-4288
dc.identifierhttp://dx.doi.org/10.1095/biolreprod.108.068759
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/867062
dc.descriptionThe present work aims to evaluate the response of the adult gerbil female prostate (paraurethral glands) and ovaries to short-term exposure to antiestrogenic agents, consisting of daily oral doses of letrozole (1 mg kg(-1) day(-1)) or intradermal doses of tamoxifen (1 mg/kg) every other day for 21 days. The serum levels of testosterone and estradiol were monitored, and the prostates and ovaries collected for structural, ultrastructural, and immunocytochemical analyses. The letrozole treatment resulted in increases of serum testosterone levels and secretory activity as well as in glandular hyperplasia and dysplastic growth, simulating the effects caused by the exogenous androgens. The effects caused by tamoxifen indicate that this endocrine agent acted as an estrogenic agonist on the prostate, causing glandular hypertrophy, secretory activity decrease, and the development of prostatic lesions. Therefore, it is possible to conclude that the letrozole and tamoxifen therapies result in a series of complex effects that endanger the physiology of hormone-dependent organs, including the female prostate and ovaries. The hormonal imbalance caused by administration of these drugs resulted in considerable changes in prostatic morphology, in a manner very similar to what occurs during the development of prostatic lesions in aged postmenopausal women. Thus, these therapies must be chosen carefully since long-term treatments can result in female prostate dysplasic lesions.
dc.descriptionConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.languageeng
dc.publisherSoc Study Reproduction
dc.relationBiology of Reproduction
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectandrogens
dc.subjectestradiol
dc.subjectfemale prostate
dc.subjectfemale reproductive tract
dc.subjectletrozole
dc.subjectmorphology
dc.subjectovary
dc.subjectprostate
dc.subjecttamoxifen
dc.titleAntiestrogen therapies affect tissue homeostasis of the gerbil (Meriones unguiculatus) female prostate and ovaries
dc.typeOtro


Este ítem pertenece a la siguiente institución