Jelleines: a family of antimicrobial peptides from the Royal Jelly of honeybees (Apis mellifera)

dc.contributorUniversidade Estadual Paulista (UNESP)
dc.creatorFontana, R.
dc.creatorMendes, M. A.
dc.creatorde Souza, B. M.
dc.creatorKonno, K.
dc.creatorCesar, LMM
dc.creatorMalaspina, O.
dc.creatorPalma, Mario Sergio
dc.date2014-05-20T13:54:43Z
dc.date2016-10-25T17:04:44Z
dc.date2014-05-20T13:54:43Z
dc.date2016-10-25T17:04:44Z
dc.date2004-06-01
dc.date.accessioned2017-04-05T21:11:29Z
dc.date.available2017-04-05T21:11:29Z
dc.identifierPeptides. New York: Elsevier B.V., v. 25, n. 6, p. 919-928, 2004.
dc.identifier0196-9781
dc.identifierhttp://hdl.handle.net/11449/19600
dc.identifierhttp://acervodigital.unesp.br/handle/11449/19600
dc.identifier10.1016/j.peptides.2004.03.016
dc.identifierWOS:000222395900003
dc.identifierhttp://dx.doi.org/10.1016/j.peptides.2004.03.016
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/865418
dc.descriptionFour antimicrobial peptides were purified from Royal Jelly of honeybees, by using reverse phase-HPLC and sequenced by using Q-Tof-MS/MS: PFKLSLHL-NH2 (Jelleine-I), TPFKLSLHL-NH2 (Jelleine-II), EPFKLSLHL-NH2 (Jelleine-III), and TPFKLSLH-NH2 (Jelleine-IV). The peptides were synthesized on-solid phase, purified and submitted to different biological assays: antimicrobial activity, mast cell degranulating activity and hemolysis. The Jelleines-I-III presented exclusively antimicrobial activities against yeast, Gram+ and Gram- bacteria; meanwhile, Jelleine-IV was not active in none of the assays performed. These peptides do not present any similarity with the other antimicrobial peptides from the honeybees; they are produced constitutively by the workers and secreted into Royal Jelly. (C) 2004 Elsevier B.V. All rights reserved.
dc.languageeng
dc.publisherElsevier B.V.
dc.relationPeptides
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectroyal jelly
dc.subjectAfricanized honeybees
dc.subjectApis mellifera
dc.subjectmass spectrometry
dc.subjectantimicrobial peptides
dc.titleJelleines: a family of antimicrobial peptides from the Royal Jelly of honeybees (Apis mellifera)
dc.typeOtro


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