Structural and functional characterization of two novel peptide toxins isolated from the venom of the social wasp Polybia paulista

dc.contributorUniversidade Estadual Paulista (UNESP)
dc.creatorSouza, B. M.
dc.creatorMendes, M. A.
dc.creatorSantos, L. D.
dc.creatorMarques, M. R.
dc.creatorCesar, LMM
dc.creatorAlmeida, RNA
dc.creatorPagnocca, F. C.
dc.creatorKonno, K.
dc.creatorPalma, Mario Sergio
dc.date2014-05-20T13:54:38Z
dc.date2016-10-25T17:04:41Z
dc.date2014-05-20T13:54:38Z
dc.date2016-10-25T17:04:41Z
dc.date2005-11-01
dc.date.accessioned2017-04-05T21:11:16Z
dc.date.available2017-04-05T21:11:16Z
dc.identifierPeptides. New York: Elsevier B.V., v. 26, n. 11, p. 2157-2164, 2005.
dc.identifier0196-9781
dc.identifierhttp://hdl.handle.net/11449/19558
dc.identifierhttp://acervodigital.unesp.br/handle/11449/19558
dc.identifier10.1016/j.peptides.2005.04.026
dc.identifierWOS:000233373100016
dc.identifierhttp://dx.doi.org/10.1016/j.peptides.2005.04.026
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/865392
dc.descriptionTwo novel inflammatory peptides were isolated from the venom of the social wasp Polybia paulista. They had their molecular masses determined by ESI-MS and their primary sequences were elucidated by Edman degradation chemistry as:Polybia-MPI: I D W K K L L D A A K Q I L-NH2 (1654.09 Da),Polybia-CP: I L G T I L G L L K S L-NH2 (1239.73 Da).Both peptides were functionally characterized by using Wistar rat cells. Polybia-MPI is a mast cell lytic peptide, which causes no hemolysis to rat erythrocytes and presents chemotaxis for polymorphonucleated leukocytes (PMNL) and with potent antimicrobial action both against Gram-positive and Gram-negative bacteria. Polybia-CP was characterized as a chemotactic peptide for PMNL cells, presenting antimicrobial action against Gram-positive bacteria, but causing no hemolysis to rat erythrocytes and no mast cell degranulation activity at physiological concentrations. (c) 2005 Elsevier B.V. All rights reserved.
dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.languageeng
dc.publisherElsevier B.V.
dc.relationPeptides
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectPolybia paulista
dc.subjecthymenoptera insect
dc.subjectpolycationic peptide
dc.subjectwasp venom
dc.subjectmastoparans
dc.subjectchemotactic peptides
dc.titleStructural and functional characterization of two novel peptide toxins isolated from the venom of the social wasp Polybia paulista
dc.typeOtro


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