In Vivo Models for Measuring Placental Glutatione-S-transferase (GST-P 7-7) Levels: A Suitable Biomarker for Understanding Cancer Pathogenesis

dc.contributorUniversidade Estadual Paulista (UNESP)
dc.creatorNoguti, Juliana
dc.creatorBarbisan, Luis Fernando
dc.creatorCesar, Augusto
dc.creatorSeabra, Camilo Dias
dc.creatorChoueri, Rodrigo Brasil
dc.creatorRibeiro, Daniel Araki
dc.date2014-05-20T13:52:12Z
dc.date2016-10-25T17:03:21Z
dc.date2014-05-20T13:52:12Z
dc.date2016-10-25T17:03:21Z
dc.date2012-07-01
dc.date.accessioned2017-04-05T21:06:28Z
dc.date.available2017-04-05T21:06:28Z
dc.identifierIn Vivo. Athens: Int Inst Anticancer Research, v. 26, n. 4, p. 647-650, 2012.
dc.identifier0258-851X
dc.identifierhttp://hdl.handle.net/11449/18654
dc.identifierhttp://acervodigital.unesp.br/handle/11449/18654
dc.identifierWOS:000306397000018
dc.identifierhttp://iv.iiarjournals.org/content/26/4/647.abstract
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/864740
dc.descriptionThe Glutatione-S-transferases (GSTs) comprise a family of enzymes closely associated with the cell detoxification of xenobiotics. GSTs exist as homo- or heterodimers and have been grouped into at least seven distinct classes. The main function of GSTs is to catalyze the conjugation of reduced glutathione (GSH) to an electrophilic site of a broad range of potentially toxic and carcinogenic compounds, thereby making such compounds less dangerous and enabling their ready-excretion. Placental GST, known as GST-P 7-7, is the main isoform found in normal placental tissue and comprises 67% of the total GST concentration in this tissue. During development, GST-P 7-7 decreases in concentration and is absent in adult tissues. Interestingly, GST-P 7-7 expression has been detected in adult tissues after exposure to carcinogenic agents in several experimental test systems, being considered a reliable biomarker of exposure and susceptibility in early phases of carcinogenesis. In this article, we review a series of studies involving GST-P 7-7 expression as a suitable tool for understanding cancer pathogenesis, especially cancer risk.
dc.languageeng
dc.publisherInt Inst Anticancer Research
dc.relationIn Vivo
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectCancer
dc.subjectin vivo models
dc.subjectGST-P 7-7
dc.subjectreview
dc.titleIn Vivo Models for Measuring Placental Glutatione-S-transferase (GST-P 7-7) Levels: A Suitable Biomarker for Understanding Cancer Pathogenesis
dc.typeOtro


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