Cell death evaluation in benzo[a]pyrene-transformed human breast epithelial cells after microcell-mediated transfer of chromosomes 11 and 17

dc.contributorUniversidade Estadual Paulista (UNESP)
dc.creatorMello, MLS
dc.creatorBarbisan, L. F.
dc.creatorLareef, M. H.
dc.creatorRusso, J.
dc.creatorVidal, B. D.
dc.date2014-05-20T13:51:30Z
dc.date2016-10-25T17:03:02Z
dc.date2014-05-20T13:51:30Z
dc.date2016-10-25T17:03:02Z
dc.date2004-02-26
dc.date.accessioned2017-04-05T21:05:21Z
dc.date.available2017-04-05T21:05:21Z
dc.identifierMutation Research-fundamental and Molecular Mechanisms of Mutagenesis. Amsterdam: Elsevier B.V., v. 546, n. 1-2, p. 39-43, 2004.
dc.identifier0027-5107
dc.identifierhttp://hdl.handle.net/11449/18417
dc.identifierhttp://acervodigital.unesp.br/handle/11449/18417
dc.identifier10.1016/j.mrfmmm.2003.10.005
dc.identifierWOS:000188838800005
dc.identifierhttp://dx.doi.org/10.1016/j.mrfmmm.2003.10.005
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/864591
dc.descriptionThe incidence of apoptosis and nuclear instability, including the incidence of catastrophic death, were investigated in benzo[a]pyrene (BP)-transformed human breast epithelial cells (BP1-E cell line) after microcell-mediated transfer of chromosomes 11 and 17. Since the introduction of normal chromosomes 11 and 17 into tumorigenic human breast BP1-E cells reverts some of these cells' characteristics (especially those affected by microsatellite instabilities and loss of heterozygosity) those of parental non-transformed MCF-10F cells, it was expected that the cell death rates would also be affected by this treatment. The transfer of the mentioned chromosomes, especially chromosome 17, to tumorigenic BP1-E cells increased the apoptotic ratios and decreased the nuclear instability ratios, thus showing that the microsatellite instability and loss of heterozygosity induced by BP in these chromosomes of MCF-10F cells affect the control of cell death mechanisms. (C) 2003 Elsevier B.V. All rights reserved.
dc.languageeng
dc.publisherElsevier B.V.
dc.relationMutation Research: Fundamental and Molecular Mechanisms of Mutagenesis
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectapoptosis
dc.subjectcatastrophic death
dc.subjecthuman breast epithelial cells
dc.subjectchromosome 11
dc.subjectchromosome 17
dc.titleCell death evaluation in benzo[a]pyrene-transformed human breast epithelial cells after microcell-mediated transfer of chromosomes 11 and 17
dc.typeOtro


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