Immunization protected well nourished mice but not undernourished ones from lung injury in Methicillin-resistant Staphylococcus aureus (MRSA) infection

dc.contributorUniversidade Estadual Paulista (UNESP)
dc.creatorDonega Franca, Thais Graziela
dc.creatorWatanabe Ishikawa, Larissa Lumi
dc.creatorGoncalves Zorzella-Pezavento, Sofia Fernanda
dc.creatorChiuso-Minicucci, Fernanda
dc.creatorFujiara Guerino, Clara Pires
dc.creatorRibeiro de Souza da Cunha, Maria de Lourdes
dc.creatorSartori, Alexandrina
dc.date2014-05-20T13:51:10Z
dc.date2014-05-20T13:51:10Z
dc.date2009-11-23
dc.date.accessioned2017-04-05T21:04:44Z
dc.date.available2017-04-05T21:04:44Z
dc.identifierBmc Microbiology. London: Biomed Central Ltd., v. 9, p. 7, 2009.
dc.identifier1471-2180
dc.identifierhttp://hdl.handle.net/11449/18271
dc.identifier10.1186/1471-2180-9-240
dc.identifierWOS:000272410800003
dc.identifierWOS000272410800003.pdf
dc.identifierhttp://dx.doi.org/10.1186/1471-2180-9-240
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/864508
dc.descriptionBackground: Staphylococcus aureus methicillin-resistant (MRSA) has been frequently isolated from endotracheal and lung puncture aspirates in malnourished children with pneumonia. In this work we evaluated the susceptibility of undernourished BALB/c mice and its ability to mount a protective immunity against MRSA with emphasis on the lung involvement.Results: BALB/c mice submitted to a 20% dietary restriction during 20 days presented a significant decrease in body weight, lymphocyte number and also atrophy in thymus and intestinal epithelium. Determination of bacterial load by the number of colony forming units (CFU) indicated a similar susceptibility whereas the findings of Gram stain clearly suggested a higher amount of bacteria in the lungs of normal mice than in the undernourished ones. Immunization reduced bacterial growth in the lungs of normal mice but not in the undernourished ones. Histopathological analysis showed that inflammation appeared in the lungs from normal mice only after infection and that immunization prevented this pulmonary inflammatory process. on the other hand, undernourished mice presented lung inflammation even before infection. In addition, the degree of this inflammatory process did not change with infection or previous immunization.Conclusion: Our results indicated that lung injury during MRSA infection is prevented by previous immunization in well nourished but not in undernourished mice.
dc.descriptionConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.languageeng
dc.publisherBiomed Central Ltd.
dc.relationBMC Microbiology
dc.rightsinfo:eu-repo/semantics/openAccess
dc.titleImmunization protected well nourished mice but not undernourished ones from lung injury in Methicillin-resistant Staphylococcus aureus (MRSA) infection
dc.typeOtro


Este ítem pertenece a la siguiente institución