Polysaccharide-rich fraction of Agaricus brasiliensis enhances the candidacidal activity of murine macrophages

dc.contributorUniversidade Estadual Paulista (UNESP)
dc.creatorMartins, Priscila Raquel
dc.creatorGameiro, Maria Carolina
dc.creatorCastoldi, Lindsey
dc.creatorRomagnoli, Graziela Gorete
dc.creatorLopes, Fabiane Catanho
dc.creatorPinto, Andréa Vanessa Ferreira da Silva
dc.creatorLoyola, Wagner
dc.creatorKaneno, Ramon
dc.date2014-05-20T13:50:48Z
dc.date2014-05-20T13:50:48Z
dc.date2008-05-01
dc.date.accessioned2017-04-05T21:04:05Z
dc.date.available2017-04-05T21:04:05Z
dc.identifierMemórias do Instituto Oswaldo Cruz. Instituto Oswaldo Cruz, Ministério da Saúde, v. 103, n. 3, p. 244-250, 2008.
dc.identifier0074-0276
dc.identifierhttp://hdl.handle.net/11449/18133
dc.identifier10.1590/S0074-02762008005000011
dc.identifierS0074-02762008000300003
dc.identifierWOS:000257282400003
dc.identifierS0074-02762008000300003.pdf
dc.identifierhttp://dx.doi.org/10.1590/S0074-02762008005000011
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/864424
dc.descriptionA polysaccharide-rich fraction (ATF) of medicinal mushroom Agaricus brasiliensis was evaluated on the candidacidal activity, H2O2 and nitric oxide (NO) production, and expression of mannose receptors by murine peritoneal macrophages. Mice received three intraperitoneal (i.p.) injections of ATF and after 48 h their peritoneal resident macrophages were assayed against Candida albicans yeast forms. The treatment increased fungicidal activity and it was associated with higher levels of H2O2, whereas NO production was not affected. We also found that the treatment enhances mannose receptor expression by peritoneal macrophages, which are involved in the attachment and phagocytosis of non-opsonized microorganisms. Treatment of animals with ATF was able to enhance the clearance of C. albicans during the first 6 h after the experimental i.p. infection. Our results suggest that this extract can increase host resistance against some infectious agents through the stimulation of microbicidal activity of macrophages.
dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.languageeng
dc.publisherInstituto Oswaldo Cruz, Ministério da Saúde
dc.relationMemórias do Instituto Oswaldo Cruz
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectCandida albicans
dc.subjectmicrobicidal activity
dc.subjectmushroom
dc.titlePolysaccharide-rich fraction of Agaricus brasiliensis enhances the candidacidal activity of murine macrophages
dc.typeOtro


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