Healing, Antioxidant and Cytoprotective Properties of Indigofera truxillensis in Different Models of Gastric Ulcer in Rats

dc.contributorUniversidade Estadual Paulista (UNESP)
dc.creatorLuiz-Ferreira, Anderson
dc.creatorCola, Maira
dc.creatorBarbastefano, Victor
dc.creatorde-Faria, Felipe Meira
dc.creatorde Almeida, Ana Beatriz A.
dc.creatorFarias-Silva, Elisangela
dc.creatorCalvo, Tamara Regina
dc.creatorHiruma-Lima, Clélia Akiko
dc.creatorVilegas, Wagner
dc.creatorSouza-Brito, Alba Regina M.
dc.date2014-05-20T13:50:01Z
dc.date2014-05-20T13:50:01Z
dc.date2012-11-01
dc.date.accessioned2017-04-05T21:02:36Z
dc.date.available2017-04-05T21:02:36Z
dc.identifierInternational Journal of Molecular Sciences. Basel: Mdpi Ag, v. 13, n. 11, p. 14973-14991, 2012.
dc.identifier1422-0067
dc.identifierhttp://hdl.handle.net/11449/17836
dc.identifier10.3390/ijms131114973
dc.identifierWOS:000311425000075
dc.identifierWOS000311425000075.pdf
dc.identifier0000-0002-8645-3777
dc.identifier0000-0003-3032-2556
dc.identifierhttp://dx.doi.org/10.3390/ijms131114973
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/864233
dc.descriptionThe present study evaluated the antiulcerogenic activity and mechanisms of the aqueous (AqF 100 mg/kg) and ethyl acetate (AcF 50 mg/kg) fractions from Indigofera truxillensis leaves. This dose was selected to assess its activity on ulcer healing and its action on gastric acid and mucus secretion, prostaglandin production and antioxidant enzyme activity (superoxide dismutase (SOD), glutathione peroxidase (GSH-Px) and glutathione reductase (GSH-Rd)). Gastric ulcer was induced by absolute ethanol. Antisecretory action, mucus and prostaglandin production, healing and antioxidant enzyme activities were evaluated for both fractions. AqF and AcF significantly inhibited the gastric mucosal damage caused by ethanol. This effect was statistically significant at 100 and 50 mg/kg compared with the vehicle. Neither fraction interfered with gastric secretion. AcF increased the PGE(2) production, and both fractions increased mucus production. L-NAME did not alter the gastroprotection exerted by the fractions, but N-ethylmaleimide attenuated only AcF. In the ischemia/reperfusion model both fractions inhibited the mucosal damage. AcF increased SOD, GSH-Px and GSH-Rd activity, but AqF increased only SOD and GSH-Px. In the acetic acid-induced ulcer model AcF only accelerated ulcer healing. These results showed that Indigofera truxillensis acted as a gastroprotective agent, stimulating protective factors and antioxidants enzymes.
dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.descriptionCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.descriptionConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.languageeng
dc.publisherMdpi Ag
dc.relationInternational Journal of Molecular Sciences
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectIndigofera truxillensis
dc.subjectgastric ulcer
dc.subjectmedicinal plants
dc.subjectantioxidant enzymes
dc.titleHealing, Antioxidant and Cytoprotective Properties of Indigofera truxillensis in Different Models of Gastric Ulcer in Rats
dc.typeOtro


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