Morphologic and Pharmacological Investigations in the Epicatechin Gastroprotective Effect

dc.contributorUniversidade Estadual Paulista (UNESP)
dc.creatorRozza, A. L.
dc.creatorHiruma-Lima, Clélia Akiko
dc.creatorTanimoto, A.
dc.creatorPellizzon, C. H.
dc.date2014-05-20T13:50:00Z
dc.date2014-05-20T13:50:00Z
dc.date2012-01-01
dc.date.accessioned2017-04-05T21:02:35Z
dc.date.available2017-04-05T21:02:35Z
dc.identifierEvidence-based Complementary and Alternative Medicine. New York: Hindawi Publishing Corporation, p. 8, 2012.
dc.identifier1741-427X
dc.identifierhttp://hdl.handle.net/11449/17834
dc.identifier10.1155/2012/708156
dc.identifierWOS:000305058800001
dc.identifierWOS000305058800001.pdf
dc.identifier0000-0002-8645-3777
dc.identifierhttp://dx.doi.org/10.1155/2012/708156
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/864231
dc.descriptionPrevious studies of the gastroprotective activity of plants have highlighted the importance of the polyphenolic compound epicatechin (EC) in the treatment of gastric ulcers. This paper aimed to evaluate and characterize the gastroprotective mechanism of action of EC using male rats. The gastroprotective action of EC was analyzed in gastric ulcers induced by ethanol or indomethacin. The involvement of sulfhydryl (SH) groups, K-ATP(+) channels, alpha(2) adrenoceptors, gastric antisecretory activity, and the amount of mucus in the development of gastric ulcers were investigated. The lowest effective dose of EC providing gastroprotective effects was 50 mg/kg in the ethanol-induced gastric ulcers and 25 mg/kg in the indomethacin-induced gastric ulcers. The gastroprotection seen upon treatment with EC was significantly decreased in rats pretreated with a SH compound reagent or an alpha(2)-receptor antagonist, but not with a K-ATP(+) channel blocker. Furthermore, oral treatment with EC increased mucus production and decreased H+ secretion. Immunohistochemistry demonstrated the involvement of superoxide dismutase (SOD), nitric oxide (NO), and heat shock protein-70 (HSP-70) in the gastroprotection. These results demonstrate that EC provides gastroprotection through reinforcement of the mucus barrier and neutralization of gastric juice and this protection occurs through the involvement of SH compounds, alpha(2)-adrenoceptors, NO, SOD, and HSP-70.
dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.languageeng
dc.publisherHindawi Publishing Corporation
dc.relationEvidence-based Complementary and Alternative Medicine
dc.rightsinfo:eu-repo/semantics/openAccess
dc.titleMorphologic and Pharmacological Investigations in the Epicatechin Gastroprotective Effect
dc.typeOtro


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