Otro
Anti-hemorrhagic Activity of Four Brazilian Vegetable Species Against Bothrops jararaca Venom
Registro en:
Molecules. Basel: Molecular Diversity Preservation International-mdpi, v. 14, n. 3, p. 1072-1080, 2009.
1420-3049
10.3390/molecules14031072
WOS:000264565000014
WOS000264565000014.pdf
0000-0002-8645-3777
0000-0003-3032-2556
Autor
Nishijima, Catarine Massucato
Rodrigues, Clenilson Martins
Silva, Marcelo Aparecido
Lopes-Ferreira, Monica
Vilegas, Wagner
Hiruma-Lima, Clélia Akiko
Resumen
Around 20,000 snakebites are reported annually in Brazil and 90% of them are inflicted by species of the genus Bothrops. Intravenous administration of antibothropic antivenom neutralizes the systemic actions, but it is of little effect on the reversal of local symptoms and often induces adverse reactions, a context that drives the search for complementary treatments for snakebite accidents. Vegetable extracts with a range of antiophidian activities constitute an excellent alternative. In this study, we investigated the anti-hemorrhagic effects of Mouriri pusa Gardn. (Melastomataceae), Byrsonima crassa Niedenzu (Malpighiaceae), Davilla elliptica St. Hill. (Dilleniaceae) and Strychnos pseudoquina St. Hil. (Loganiaceae) against Bothrops jararaca venom. The methanolic extracts from M. pusa (leaves), B. crassa (leaves) and D. elliptica (leaves) showed total neutralization capacity against local hemorrhages. The amenthoflavone and quercetin fractions from B. crassa and the flavonoids fractions (quercetin and myricetin) from M. pusa and D. elliptica also showed total neutralization capacity. We conclude that flavonoids derived from myricetin, quercetin and amenthoflavone play an important role in the anti-hemorrhagic potential of these Brazilian vegetables species against B. jararaca venom. Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP) Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)