The gastroprotective effect of the essential oil of Croton cajucara is different in normal rats than in malnourished rats

dc.contributorUniversidade Estadual Paulista (UNESP)
dc.creatorPaula, A. C. B.
dc.creatorToma, W.
dc.creatorGracioso, J. S.
dc.creatorHiruma-Lima, C. A.
dc.creatorCarneiro, E. M.
dc.creatorBrito, A. R. M. Souza
dc.date2014-05-20T13:49:48Z
dc.date2014-05-20T13:49:48Z
dc.date2006-08-01
dc.date.accessioned2017-04-05T21:02:11Z
dc.date.available2017-04-05T21:02:11Z
dc.identifierBritish Journal of Nutrition. Cambridge: Cambridge Univ Press, v. 96, n. 2, p. 310-315, 2006.
dc.identifier0007-1145
dc.identifierhttp://hdl.handle.net/11449/17769
dc.identifier10.1079/BJN20061827
dc.identifierWOS:000239971500013
dc.identifierWOS000239971500013.pdf
dc.identifier0000-0002-8645-3777
dc.identifierhttp://dx.doi.org/10.1079/BJN20061827
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/864179
dc.descriptionIt has been shown previously that malnourished rats are resistant to acute gastric lesions but not to subchronic gastric ulceration. It also has been demonstrated that the essential oil obtained from the bark of Croton cajucara (Sacaca) has antiulcer properties. In the present study, the ability of this essential oil to prevent the formation of gastric ulcers in rats fed a diet with 17 % protein (normoproteic rats) or 6 % protein (malnourished rats) was investigated. At a dose of 100 mg/kg body weight, orally, the essential oil significantly reduced the gastric injury caused by indomethacin (25 % after 2 h and 70 % after 4 h) only in normoproteic rats. In the pylorus ligature model, the essential oil increased the pH and gastric volume, but decreased the total acid concentration in both groups when compared to the respective control group. The essential oil significantly increased prostaglandin E2 production in glandular cells by 50 % compared to the controls in both groups of rats. In addition, the amount of gastric mucus was two-fold higher in malnourished rats than in normoproteic rats. The present results show that the enhanced protective effect of essential oil in malnourished rats involved an increase in prostaglandin E2 production and mucus secretion, which are both factors that protect the gastric mucosa against damage. In agreement with this, malnourished rats always had a lower number of acute gastric ulcers.
dc.languageeng
dc.publisherCambridge University Press
dc.relationBritish Journal of Nutrition
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectantiulcerogenic activity
dc.subjectCroton cajucara
dc.subjectcytoprotection
dc.subjectessential oil malnourished rats
dc.titleThe gastroprotective effect of the essential oil of Croton cajucara is different in normal rats than in malnourished rats
dc.typeOtro


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