Snake venom phospholipase A(2) inhibitors: Medicinal chemistry and therapeutic potential

dc.contributorUniversidade Estadual Paulista (UNESP)
dc.creatorMarcussi, Silvana
dc.creatorOliveira, Clayton Z.
dc.creatorSant'Ana, Carolina D.
dc.creatorQuintero, Aristides
dc.creatorMenaldo, Danilo L.
dc.creatorBeleboni, Rene O.
dc.creatorStabeli, Rodrigo G.
dc.creatorGiglio, Jose R.
dc.creatorFontes, Marcos R. M.
dc.creatorSoares, Andreimar M.
dc.date2014-05-20T13:49:24Z
dc.date2016-10-25T17:01:54Z
dc.date2014-05-20T13:49:24Z
dc.date2016-10-25T17:01:54Z
dc.date2007-01-01
dc.date.accessioned2017-04-05T21:01:13Z
dc.date.available2017-04-05T21:01:13Z
dc.identifierCurrent Topics In Medicinal Chemistry. Sharjah: Bentham Science Publ Ltd, v. 7, n. 8, p. 743-756, 2007.
dc.identifier1568-0266
dc.identifierhttp://hdl.handle.net/11449/17611
dc.identifierhttp://acervodigital.unesp.br/handle/11449/17611
dc.identifier10.2174/156802607780487614
dc.identifierWOS:000247023500002
dc.identifierhttp://dx.doi.org/10.2174/156802607780487614
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/864052
dc.descriptionPhospholipases A(2) (PLA(2)s) are commonly found in snake venoms from Viperidae, Hydrophidae and Elaphidae families and have been extensively studied due to their pharmacological and physiopathological effects in living organisms. This article reports a review on natural and artificial inhibitors of enzymatic, toxic and pharmacological effects induced by snake venom PLA(2)s. These inhibitors act on PLA(2)S through different mechanisms, most of them still not completely understood, including binding to specific domains, denaturation, modification of specific amino acid residues and others. Several substances have been evaluated regarding their effects against snake venoms and isolated toxins, including plant extracts and compounds from marine animals, mammals and snakes serum plasma, in addition to poly or monoclonal antibodies and several synthetic molecules. Research involving these inhibitors may be useful to understand the mechanism of action of PLA(2)s and their role in envenomations caused by snake bite. Furthermore, the biotechnological potential of PLA(2) inhibitors may provide therapeutic molecular models with antiophidian activity to supplement the conventional serum therapy against these multifunctional enzymes.
dc.languageeng
dc.publisherBentham Science Publ Ltd
dc.relationCurrent Topics In Medicinal Chemistry
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectphospholipases A(2)
dc.subjectphospholipase A(2) inhibitors
dc.subjectnatural and artificial inhibitors
dc.subjectsnake venoms
dc.titleSnake venom phospholipase A(2) inhibitors: Medicinal chemistry and therapeutic potential
dc.typeOtro


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