Davilla elliptica and Davilla nitida: Gastroprotective, anti-inflammatory immunomodulatory and anti-Helicobacter pylori action

dc.contributorUniversidade Estadual Paulista (UNESP)
dc.creatorKushima, Helio
dc.creatorNishijima, Catarine Massucato
dc.creatorRodrigues, Clenilson Martins
dc.creatorRinaldo, Daniel
dc.creatorSassa, Micheli Fernanda
dc.creatorBauab, Tais Maria
dc.creatorDi Stasi, Luiz Claudio
dc.creatorCarlos, Iracilda Zeppone
dc.creatorMonteiro Souza Brito, Alba Regina
dc.creatorVilegas, Wagner
dc.creatorHiruma-Lima, Clélia Akiko
dc.date2014-05-20T13:49:11Z
dc.date2014-05-20T13:49:11Z
dc.date2009-06-25
dc.date.accessioned2017-04-05T21:00:37Z
dc.date.available2017-04-05T21:00:37Z
dc.identifierJournal of Ethnopharmacology. Clare: Elsevier B.V., v. 123, n. 3, p. 430-438, 2009.
dc.identifier0378-8741
dc.identifierhttp://hdl.handle.net/11449/17509
dc.identifier10.1016/j.jep.2009.03.031
dc.identifierWOS:000267557500010
dc.identifier0000-0002-8645-3777
dc.identifier0000-0003-3032-2556
dc.identifierhttp://dx.doi.org/10.1016/j.jep.2009.03.031
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/863976
dc.descriptionEthnopharmacological relevance: Davilla elliptica and Davilla nitida are species commonly found in the Brazilian Cerrado biome.Aim of the study: Based on ethnopharmacological and phytochemical analyses, methanolic extracts from leaves of Davilla elliptica (EDE) and Davilla nitida (EDN) were evaluated for their anti-ulcer, anti-inflammatory, immunological and anti-Helicobacter pylori activities.Materials and methods: The gastroprotective action of both extracts was evaluated in rodent experimental models (HCl/ethanol, ethanol or NSAID). We also evaluated anti-inflammatory (carrageenin-induced rat hind paw edema), immunomodulatory (murine peritoneal macrophages) and antibacterial action of both extracts against a standard strain of Helicobacter pylori.Results: EDE and EDN (500 mg/kg) were able to protect gastric mucosa against HCl/ethanol solution (EDE 63%; EDN 59%), absolute ethanol (EDE 95%; EDN 88%), and also against injurious effect of NSAID (EDE 77%: EDN 67%). When EDE and EDN were challenged with sulfhydryl depleter compound, the gastroprotective action of both extracts was completely abolished. EDE had gastroprotective effect related to increase of glutathione bioavailability and stimulated higher levels of NO, H(2)O(2) and TNF-alpha production. Otherwise EDN showed better anti-Helicobacter pylori action than EDE. Neither extracts presented anti-inflammatory activity by oral route.Conclusion:The phytochemical investigation showed that both extracts possess phenolic acid derivatives, acylglycoflavonoids and condensed tannins with evident quantitative variations that probably influenced the pharmacological differences between extracts. Published by Elsevier B.V.
dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.descriptionCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.descriptionConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.languageeng
dc.publisherElsevier B.V.
dc.relationJournal of Ethnopharmacology
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectDavilla elliptica St. Hil.
dc.subjectDavilla nitida (Vahl) Kubitzki
dc.subjectDilleniaceae
dc.subjectGastric protection
dc.subjectAnti-Helicobacter pylori activity
dc.subjectGlutathione
dc.titleDavilla elliptica and Davilla nitida: Gastroprotective, anti-inflammatory immunomodulatory and anti-Helicobacter pylori action
dc.typeOtro


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