Qualea parviflora Mart.: An integrative study to validate the gastroprotective, antidiarrheal, antihemorragic and mutagenic action

dc.contributorUniversidade Estadual Paulista (UNESP)
dc.creatorMazzolin, Lucilene Patricia
dc.creatorMartiniano Nasser, Ana Lucia
dc.creatorMoraes, Thiago Mello
dc.creatorSantos, Raquel Cassia
dc.creatorNishijima, Catarine Massucato
dc.creatorSantos, Fabio Vieira
dc.creatorVaranda, Eliana Aparecida
dc.creatorBauab, Tais Maria
dc.creatorMachado da Rocha, Lucia Regina
dc.creatorDi Stasi, Luis Claudio
dc.creatorVilegas, Wagner
dc.creatorHiruma-Lima, Clélia Akiko
dc.date2014-05-20T13:49:10Z
dc.date2014-05-20T13:49:10Z
dc.date2010-02-03
dc.date.accessioned2017-04-05T21:00:36Z
dc.date.available2017-04-05T21:00:36Z
dc.identifierJournal of Ethnopharmacology. Clare: Elsevier B.V., v. 127, n. 2, p. 508-514, 2010.
dc.identifier0378-8741
dc.identifierhttp://hdl.handle.net/11449/17506
dc.identifier10.1016/j.jep.2009.10.005
dc.identifierWOS:000274833200045
dc.identifier0000-0002-8645-3777
dc.identifier0000-0003-3032-2556
dc.identifierhttp://dx.doi.org/10.1016/j.jep.2009.10.005
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/863973
dc.descriptionEthnopharmacological relevance: Qualea parviflora Mart. is a medicinal species commonly found in the Brazilian Cerrado biome.Aim of the study: Based on ethnopharmacological data, methanolic extract from Qualea parviflora (QP) bark was evaluated for its antiulcer, analgesic, anti-hemorrhagic, mutagenic and anti-Helicobacter pylori activities.Material and methods: The gastroprotective action of the extract was evaluated in rodent experimental models (HCl/ethanol, ethanol or NSAID). We also evaluated mutagenic effect (Ames assay), anti-Helicobacter pylori, anti-hemorrhagic action, analgesic and inflammatory effects (hot-plate test and carrageenin-induced hind paw edema) of methanolic extract from Qualea parviflora.Results: QP (500 mg/kg, p.o.) was able to protect gastric mucosa against HCl/ethanol solution (77%), absolute ethanol (97%), and also against injurious effect of NSAID (36%). When QP was challenged with sulfhydryl depletor compound, the gastroprotective action of extract was abolished. QP treatment was able to maintain the GSH level and show a concentration-de pendent inhibition effect on the lipid peroxidation. QP present anti-Helicobacter pylori effect (MIC = 75 mu g/mL), anti-hemorrhagic and antidiarrheal action but not present analgesic or anti-inflammatory effect.Conclusion: methanolic extract from Qualea parviflora had gastroprotective effect related to the increase of gastric mucosa defensive factors such PGE(2) levels and maintain the basal gastric glutathione levels. The methanolic extract also showed anti-Helicobacter pylori activity, anti-hemorrhagic effect and antioxidant action, but absence of analgesic, mutagenic and toxic effects, a profile that adds safety to its use. Published by Elsevier B.V.
dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.descriptionConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.descriptionCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.languageeng
dc.publisherElsevier B.V.
dc.relationJournal of Ethnopharmacology
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectQualea parviflora Mart.
dc.subjectVochysiaceae
dc.subjectGastric protection
dc.subjectAnti-Helicobacter pylori
dc.subjectPGE(2) level
dc.subjectGlutathione
dc.titleQualea parviflora Mart.: An integrative study to validate the gastroprotective, antidiarrheal, antihemorragic and mutagenic action
dc.typeOtro


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