Expression of fibroblast growth factor-8 and its cognate receptors, fibroblast growth factor receptor (FGFR)-3c and-4, in fetal bovine preantral follicles

dc.contributorUniversidade Estadual Paulista (UNESP)
dc.creatorBuratini, J.
dc.creatorGlapinski, V. F.
dc.creatorGiometti, I. C.
dc.creatorTeixeira, A. B.
dc.creatorCosta, I. B.
dc.creatorAvellar, MCW
dc.creatorBarros, C. M.
dc.creatorPrice, C. A.
dc.date2014-05-20T13:49:00Z
dc.date2016-10-25T17:01:37Z
dc.date2014-05-20T13:49:00Z
dc.date2016-10-25T17:01:37Z
dc.date2005-03-01
dc.date.accessioned2017-04-05T21:00:12Z
dc.date.available2017-04-05T21:00:12Z
dc.identifierMolecular Reproduction and Development. Hoboken: Wiley-liss, v. 70, n. 3, p. 255-261, 2005.
dc.identifier1040-452X
dc.identifierhttp://hdl.handle.net/11449/17440
dc.identifierhttp://acervodigital.unesp.br/handle/11449/17440
dc.identifier10.1002/mrd.20205
dc.identifierWOS:000226695700002
dc.identifierhttp://dx.doi.org/10.1002/mrd.20205
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/863920
dc.descriptionParacrine cell signaling is thought to be important for ovarian follicle development, and a role for some members of the fibroblast growth factor (FGF) family have been suggested. In the present study, we tested the hypothesis that FGF-8 and its cognate receptors (FGFR-3c and FGFR-4) are expressed in bovine preantral follicles. Reverse transcription-polymerase chain reaction was used to amplify bovine FGF-8, FGFR-3c, and FGFR-4 from preantral follicle samples and a variety of fetal and adult tissues. All three genes were widely expressed in fetal tissues, with a restricted expression pattern in adult tissues. FGF-8 and FGFR-3c were expressed in secondary follicles in 70% of fetuses examined, whereas FGFR-4 expression was significantly less frequent (20%). FGFR-3c expression frequency was significantly lower in primordial compared to secondary follicles, and FGF-8 expression showed a similar trend. FGFR-4 was only observed when all follicle classes of an individual were expressing both FGF-8 and FGFR-3c. We conclude that FGF-8 and its receptors are expressed in preantral follicles in a developmentally regulated manner. (C) 2005 Wiley-Liss, Inc.
dc.languageeng
dc.publisherWiley-Blackwell
dc.relationMolecular Reproduction and Development
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectfibroblast growth factor-8
dc.subjectfibroblast growth factor receptor-3c
dc.subjectfibroblast growth factor receptor-4
dc.subjectpreantral follicle
dc.subjectovary
dc.titleExpression of fibroblast growth factor-8 and its cognate receptors, fibroblast growth factor receptor (FGFR)-3c and-4, in fetal bovine preantral follicles
dc.typeOtro


Este ítem pertenece a la siguiente institución