Morphological alterations in the epithelium of the oral mucosa of rats (Rattus norvegicus) submitted to long-term systemic nicotine treatment

dc.contributorUniversidade Estadual Paulista (UNESP)
dc.creatorCaldeira, Eduardo Jose
dc.creatorFabrega Carvalho, Cesar Alexandre
dc.creatorPadovani, Carlos Roberto
dc.creatorCamilli, Jose Angelo
dc.creatorGarcia, Progresso Jose
dc.creatorAlves Cagnon, Valeria Helena
dc.date2014-05-20T13:47:29Z
dc.date2016-10-25T17:00:52Z
dc.date2014-05-20T13:47:29Z
dc.date2016-10-25T17:00:52Z
dc.date2007-01-01
dc.date.accessioned2017-04-05T20:57:32Z
dc.date.available2017-04-05T20:57:32Z
dc.identifierArchives of Oral Biology. Oxford: Pergamon-Elsevier B.V., v. 52, n. 1, p. 83-89, 2007.
dc.identifier0003-9969
dc.identifierhttp://hdl.handle.net/11449/16905
dc.identifierhttp://acervodigital.unesp.br/handle/11449/16905
dc.identifier10.1016/j.archoralbio.2006.07.008
dc.identifierWOS:000243460800012
dc.identifierhttp://dx.doi.org/10.1016/j.archoralbio.2006.07.008
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/863566
dc.descriptionSmoking is considered to be the most albeit preventable cause of diseases and premature deaths in the history of mankind. The local action of tobacco on the oral mucosa can cause precancerous and cancerous lesions. However, there is not enough evidence to establish all the systemic effects caused by nicotine on the organism. Thus, the aim of the present study was to characterize the cellular changes of the cheek mucosa of rats submitted to long-term systemic nicotine treatment. Twenty male rats were divided into two experimental groups: a nicotine group and a control group, each consisting of 10 animals. The nicotine group was injected daily with 0.250 mg of nicotine per 100 g of body weight. All animals received a solid diet and water ad libitum. After 90 days of treatment, all animals were weighed and sacrificed. Samples of cheek mucosa were collected for light and transmission electron microscopy. The results revealed oral epithelium containing atypical cells that were characterized by atrophy, cell membrane disorganization and tissue damage. It was concluded that systemic administration of nicotine damaged the cellular integrity of the oral mucosa, impairing tissue function and predisposing the tissue to the action of different pathogenic agents and also to that of other carcinogenic substances present in tobacco. (c) 2006 Elsevier Ltd. All rights reserved.
dc.languageeng
dc.publisherElsevier B.V.
dc.relationArchives of Oral Biology
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectoral mucosa
dc.subjectstructure
dc.subjectnicotine treatment
dc.titleMorphological alterations in the epithelium of the oral mucosa of rats (Rattus norvegicus) submitted to long-term systemic nicotine treatment
dc.typeOtro


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