Chemical and biological evaluation of Amazonian medicinal plant Vouacapoua americana Aubl.

dc.contributorSERHAT SEZAI ÇIÇEK, CHRISTIAN-ALBRECHTS-UNIVERSITÄT ZU KIEL
dc.contributorANNA LAÍS PFEIFER BARBOSA, CHRISTIAN-ALBRECHTS-UNIVERSITÄT ZU KIEL
dc.contributorARLETTE WENZEL-STORJOHANN, GEOMAR HELMHOLTZ-ZENTRUM FÜR OZEANFORSCHUNG KIEL
dc.contributorJORGE FEDERICO ORELLANA SEGOVIA, CPAF-AP
dc.contributorROBERTO MESSIAS BEZERRA, UNIVERSIDADE FEDERAL DO AMAPÁ
dc.contributorFRANK SÖNNICHSEN, CHRISTIAN-ALBRECHTS-UNIVERSITÄT ZU KIEL
dc.contributorCHRISTIAN ZIDORN, CHRISTIAN-ALBRECHTS-UNIVERSITÄT ZU KIEL
dc.contributorISAMU KANZAKI, UNIVERSIDADE DE BRASÍLIA
dc.contributorDENIZ TASDEMIR, GEOMAR HELMHOLTZ-ZENTRUM FÜR OZEANFORSCHUNG KIEL.
dc.creatorÇIÇEK, S. S.
dc.creatorBARBOSA, A. L. P.
dc.creatorWENZEL-STORJOHANN, A.
dc.creatorSEGOVIA, J. F. O.
dc.creatorBEZERRA, R. M.
dc.creatorSÖNNICHSEN, F.
dc.creatorZIDORN, C.
dc.creatorKANZAKI, I.
dc.creatorTASDEMIR, D.
dc.date2022-12-27T18:01:19Z
dc.date2022-12-27T18:01:19Z
dc.date2022-12-27
dc.date2023
dc.date.accessioned2023-09-05T02:05:02Z
dc.date.available2023-09-05T02:05:02Z
dc.identifierPlants, v. 12, n. 1, 99, 2023.
dc.identifierhttp://www.alice.cnptia.embrapa.br/alice/handle/doc/1150380
dc.identifierhttps://doi.org/10.3390/plants12010099
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/8634229
dc.descriptionVouacapoua americana (Fabaceae) is an economically important tree in the Amazon region and used for its highly resistant heartwood as well as for medicinal purposes. Despite its frequent use, phytochemical investigations have been limited and rather focused on ecological properties than on its pharmacological potential. In this study, we investigated the phytochemistry and bioactivity of V. americana stem bark extract and its constituents to identify eventual lead structures forfurther drug development. Applying hydrodistillation and subsequent GC-MS analysis, we investigated the composition of the essential oil and identified the 15 most abundant components. Moreover, the diterpenoids deacetylchagresnone (1), cassa-13(14),15-dien-oic acid (2), isoneocaesalpin H (3), (+)-vouacapenic acid (4), and (+)-methyl vouacapenate (5) were isolated from the stem bark, with compounds 2 and 4 showing pronounced effects on Methicillin-resistant Staphylococcus aureus and Enterococcus faecium, respectively. During the structure elucidation of deacetylchagresnone (1), which was isolated from a natural source for the first time, we detected inconsistencies regarding the configuration of the cyclopropane ring. Thus, the structure was revised for both deacetylchagresnone (1) and the previously isolated chagresnone. Following our works on Copaifera reticulata and Vatairea guianensis, the results of this study further contribute to the knowledge of Amazonian medicinal plants.
dc.languageIngles
dc.languageen
dc.rightsopenAccess
dc.subjectAcapu
dc.subjectCaesalpinioideae
dc.subjectCytotoxicity
dc.subjectAntibacterial plants
dc.titleChemical and biological evaluation of Amazonian medicinal plant Vouacapoua americana Aubl.
dc.typeArtigo de periódico


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