Influence of arginine vasopressin receptors and angiotensin receptor subtypes on the water intake and arterial blood pressure induced by vasopressin injected into the lateral septal area of the rat

dc.contributorUniversidade Estadual Paulista (UNESP)
dc.creatorSaad, W. A.
dc.creatorCamargo, LAD
dc.creatorCerri, Paulo Sérgio
dc.creatorSimoes, S.
dc.creatorGarcia, G.
dc.creatorGutierrez, L. I.
dc.creatorGuarda, I
dc.creatorGuarda, R. S.
dc.date2014-05-20T13:46:45Z
dc.date2016-10-25T17:00:23Z
dc.date2014-05-20T13:46:45Z
dc.date2016-10-25T17:00:23Z
dc.date2004-03-31
dc.date.accessioned2017-04-05T20:55:49Z
dc.date.available2017-04-05T20:55:49Z
dc.identifierAutonomic Neuroscience-basic & Clinical. Amsterdam: Elsevier B.V., v. 111, n. 1, p. 66-70, 2004.
dc.identifier1566-0702
dc.identifierhttp://hdl.handle.net/11449/16569
dc.identifierhttp://acervodigital.unesp.br/handle/11449/16569
dc.identifier10.1016/j.autneu.2003.08.013
dc.identifierWOS:000221315700008
dc.identifierhttp://dx.doi.org/10.1016/j.autneu.2003.08.013
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/863333
dc.descriptionIn this study we investigated the influence of d(CH2)(5)-Tyr(Me)-[Arg(8)]vasopressin (AAVP) and [adamanteanacetyl(1),0-ET-DTyr(2), Val(4), aminobutyryl(6), Arg(8,9)]-[Arg(8)]vasopressin (ATAVP), which are antagonists of vasopressin V-1 and V-2 receptors, and the effects of losartan, a selective angiotensin AT(1) receptor antagonist, and CGP42112A, a selective AT(2) receptor antagonist, injected into the lateral septal area (LSA) on thirst and hypertension induced by [Arg(8)]vasopressin (AVP). AAVP and ATAVP injected into the LSA reduced the drinking responses elicited by injecting AVP into the LSA. Both the AT(1) and AT(2) ligands administered into the LSA elicited a concentration-dependent decrease in the water intake induced by AVP injected into the LSA, but losartan was more effective than CGP42112A. The increase in MAP, due to injection of AVP into the LSA, was reduced by prior injection of AAVP from 18 +/- 1 to 6 +/- 1 mm Hg. Losartan injected into the LSA prior to AVP reduced the increase in MAP to 7 +/- 0.8 mm Hg. ATAVP and CGP42112A produced no changes in the pressor effect of AVP. These results suggest that the dipsogenic effects induced by injecting AVP into the LSA were mediated primarily by AT(1) receptors. However, doses of losartan were more effective when combined with CGP42112A than when given alone, suggesting that the thirst induced by AVP injections into LSA may involve activation of multiple AVP and angiotensin II receptor subtypes. The pressor response of AVP was reduced by losartan and by AAVP. CGP42112A and ATAVP did not change the AVP pressor response. These results suggest that facilitator effects of AVP on water intake are mediated through the activation of V-1 receptors and that the inhibitory effect requires V-2 receptors. The involvement of AT(1) and AT(2) receptors can be postulated. Based on the present findings, we suggest that the AVP in the LSA may play a role in the control of water and arterial blood pressure balance. (C) 2004 Elsevier B.V. All rights reserved.
dc.languageeng
dc.publisherElsevier B.V.
dc.relationAutonomic Neuroscience-basic & Clinical
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectvasopressin
dc.subjectantagonist V-1
dc.subjectantagonist V-2
dc.subjectangiotensin receptor subtypes
dc.subjectwater intake
dc.subjectarterial pressure
dc.subjectlateral septal area
dc.titleInfluence of arginine vasopressin receptors and angiotensin receptor subtypes on the water intake and arterial blood pressure induced by vasopressin injected into the lateral septal area of the rat
dc.typeOtro


Este ítem pertenece a la siguiente institución